The effects of estrogen-responsive element- and ligand-induced structural changes on the recruitment of cofactors and transcriptional responses by ERα and ERβ

Molecular Endocrinology

Volumn 16, Issue 4, 2002, Pages 674-693

  Yi, Ping ^a   Driscoll, Mark D ^a   Huang, Jing ^a   Bhagat, Sumedha ^a   Hilf, Russell ^a   Bambara, Robert A ^a   Muyan, Mesut ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b Molecular Staging Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; LIGAND; TRANSCRIPTION FACTOR; TRANSCRIPTIONAL INTERMEDIARY FACTORY 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ESTROGEN RESPONSIVE ELEMENT; GENE INDUCTION; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DNA INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; CELL LINE; CHO CELLS; CRICETINAE; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; HELA CELLS; HUMANS; LIGANDS; MALE; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS);

ANIMALIA;

EID: 0036213439     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.16.4.674     Document Type: Article

References (87)

1. ERβ: Identification and characterization of a novel human estrogen receptor
2. The novel estrogen receptor-β subtype: Potential role in the cell- and promoter-specific actions of estrogens and antiestrogens
3. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β
4. A comparison of transcriptional activation by ERα and ERβ
5. Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites
6. Transcription activation by the human estrogen receptor subtype β (ERβ) studied with ERβ and ERα receptor chimeras
7. The estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens
8. Agonistic effect of tamoxifen is dependent on cell type, ERE-promoter context, and estrogen receptor subtype: Functional difference between estrogen receptors α and β
9. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β
10. Estrogen receptor β: Re-evaluation of estrogen and antiestrogen signaling
11. Characterization of hormone response elements
12. Sequence requirements for estrogen receptor binding to estrogen response elements
13. Interaction of human estrogen receptors α and β with the same naturally occurring estrogen response
14. The role of estrogen response elements in expression of the Xenopus laevis vitellogenin B1 gene
15. Cooperative binding of estrogen receptor to imperfect estrogen-responsive DNA elements correlates with their synergistic hormone-dependent enhancer activity
16. Synergistic activation of transcription by the human estrogen receptor bound to tandem responsive elements
17. DNA allosterically modulates the steroid binding domain of the estrogen receptor
18. The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements
19. The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation
20. Human estrogen receptor bound to an estrogen response element bends DNA
21. Estrogen response elements function as allosteric modulators of estrogen receptor conformation
22. Allosteric effects of DNA on transcriptional regulators
23. Mechanisms of antihormone action
24. Steroid hormones, receptors, and antagonists
25. Tamoxifen, raloxifene, and the prevention of breast cancer
26. Molecular basis of agonism and antagonism in the oestrogen receptor
27. Structure of the ligand-binding domain of oestrogen receptor β in the presence of a partial agonist and a full antagonist
28. Molecular modelling of the human estrogen receptor and ligand interactions based on site-directed mutagenesis and amino acid sequence homology
29. Binding of site-directed monoclonal antibodies to an epitope located in the A/B region (amino acids 140-154) of human estrogen receptor-induced conformational changes in an epitope in the DNA-binding domain
30. A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor
31. Tripartite steroid hormone receptor pharmacology: Interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones
32. Estrogen receptor binding to a DNA response element in vitro is not dependent upon estradiol
33. Identification of estrogen-responsive DNA sequences by transient expression experiments in a human breast cancer cell line
34. Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence
35. Estrogen receptor affinity and location of consensus and imperfect estrogen response elements influence transcription activation of simplified promoters
36. Solution structure of the DNA-binding domain of the oestrogen receptor
37. The missing nucleoside experiment: A new technique to study recognition of DNA by protein
38. Conformational and electrostatic properties of unoccupied and liganded estrogen receptors determined by aqueous two-phase partitioning
39. Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein
40. Estrogen receptor-associated proteins: Possible mediators of hormone-induced transcription
41. Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain
42. Analysis of the structural core of the human estrogen receptor ligand binding domain by selective proteolysis/mass spectrometric analysis
43. Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-α and estrogen receptor-β: Correlations with biological character and distinct differences among SRC coactivator family members
44. Human estrogen receptor forms multiple protein-DNA complexes
45. Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo
46. The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1
47. Nuclear receptors: Coactivators, corepressors and chromatin remodeling in the control of transcription
48. Nuclear receptor coregulators: Cellular and molecular biology
49. The coregulator exchange in transcriptional functions of nuclear receptors
50. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
51. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
52. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
53. The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18
54. Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor
55. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
56. Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER)α and ERβ
57. New screening methods for chemicals with hormonal activities using interaction of nuclear hormone receptor with coactivator
58. Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain
59. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains
60. Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
61. Analysis of ligand dependence and hormone response element synergy in transcription by estrogen receptor
62. The human estrogen receptor has transcriptional activator and repressor functions in the absence of ligand
63. The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties
64. The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function
65. Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator
66. Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells
67. Estrogen receptor activation function 1 works by binding p160 coactivator proteins
68. Synergy between estrogen receptor α activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2
69. Cellular mechanisms which distinguish between hormone- and antihormone-activated estrogen receptor
70. Peptide mapping
71. Mechanistic aspects of estrogen receptor activation probed with constitutively active estrogen receptors: Correlations with DNA and coregulator interactions and receptor conformational changes
72. Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation
73. Structural analysis of covalently labeled estrogen receptors by limited proteolysis and monoclonal antibody reactivity
74. High affinity binding of the estrogen receptor to a DNA response element does not require homodimer formation or estrogen
75. The dissociation rate of estrogen receptor α from the consensus estrogen response element
76. Quantitative characterization of the interaction between purified human estrogen receptor α and DNA using fluorescence anisotropy
77. Functional domains of the human estrogen receptor
78. Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions
79. Ligand-independent activation of the estrogen receptors α and β by mutations of a conserved tyrosine can be abolished by antiestrogens
80. Interaction of estrogen receptors α and β with estrogen response elements
81. Allosteric modulation of estrogen receptor conformation by different estrogen response elements
82. Estrogen response elements alter coactivator recruitment through allosteric modulation of estrogen receptor β conformation
83. The complete primary structure of human estrogen receptor β (hERβ) and its heterodimerization with ERα in vivo and in vitro
84. Fusion estrogen receptor proteins: Towards the development of receptor-based agonists and antagonists
85. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1
86. Marked effects of salt on estrogen receptor binding to DNA: Biologically relevant discrimination between DNA sequences
87. The 43 residue DNA binding domain of γ δ resolvase binds adjacent major and minor grooves of DNA