Binding of site-directed monoclonal antibodies to an epitope located in the A/B region (amino acids 140-154) of human estrogen receptor-induced conformational changes in an epitope in the DNA-binding domain

Steroids

Volumn 61, Issue 9, 1996, Pages 549-556

  Traish, Abdulmaged M ^a   Pavao, Matthew ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

conformational changes; distal epitopes; DNA binding domain; estrogen receptor; hybrid peptides; monoclonal antibodies

Indexed keywords

EPITOPE; ESTROGEN; ESTROGEN RECEPTOR; HYBRID PROTEIN; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIGEN BINDING; ARTICLE; CONFORMATIONAL TRANSITION; DNA BINDING; PROTEIN ANALYSIS; PROTEIN STRUCTURE; RECEPTOR BINDING; SEQUENCE ANALYSIS;

EID: 0030248923     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(96)00109-2     Document Type: Article

References (18)

1. 1. Tora L, White J, Brou C. Tasset D, Webster N, Scheer E, Chambon P (1989). The human estrogen receptor has two independent non-acidic transcriptional activation functions. Cell 59:477-487.
2. 2. Kumar V, Chambon P (1988). The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell 55:145-156.
3. 3. Kumar V, Green S, Stack G, Berry M, Jin J, Chambon P (1987). Functional domains of the human estrogen receptor. Cell 51:941-951.
4. 4. Kumar V, Green S, Staub A, Chambon P (1986). Localization of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor. EMBO J 5:2231-2236.
5. 5. Tasset D, Tora L, Fromental C, Scheer E, Chambon P (1990). Distinct classes of transcriptional activating domains function by different mechanisms. Cell 62:1177-1178.
6. 6. Chambraud B, Berry M, Redeuilh G, Chambon P, Baulieu E (1990). Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes. J Biol Chem 265:20686-20691.
7. 7. Traish AM, Kim N, Wotiz HH (1989). Characterization of polyclonal antibodies to preselected domains of the human estrogen receptor. Endocrinology 125:172-179.
8. 8. Traish AM, Ettinger R, Kim N, Marshak-Rothslein A, Wotiz HH (1990). Development and characterization of monoclonal antibodies to a specific domain of human estrogen receptor. Steroids 55:196-208.
9. 9. Traish AM, Kim N, Wotiz HH (1990). Site-directed polyclonal antibodies inhibit binding of activated estrogen receptor to DNA. Steroids 55:551-556.
10. 10. Traish AM, Netsuwan N (1993). Antibodies to human estrogen receptor recognize the native receptor form and a 55 kDa nuclear protein in estrogen target tissues. 75th Annual Meeting of the Endocrine Society. Programs and Abstracts. p. 517, Abstract 1863.
11. 11. Traish AM, Al-Fadhli S, Klinge C, Kounine M, Quick TC (1995) Identification of structurally altered estrogen receptors in human breast cancer by site-directed monoclonal antibodies. Steroids 60: 467-474.
12. 12. Schaaper WMM, Lankhof H, Puijk WC, Meloen RH (1989). Manipulation of antipeptide immune response by varying the coupling of the peptide with the carrier protein. Mol Immunol 26:81-85.
13. 13. Schwabe JWR, Chapman L, Finch JT, Rhodes D (1993). The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements. Cell 75:567-578.
14. 14. Pearce D, Yamamoto KR (1993). Mineralocorticoid and glucocorticoid receptor activities distinguished by non-receptor factors at a composite response element. Science 259:1161-1165.
15. 15. Landel CC, Kushner PJ, Greene GL (1994). The interactions of human estrogen receptor with DNA is modulated by receptor associated proteins. Mol Endocrinol 8:1407-1419.
16. 16. Fan BR, Bruni R, Taeusch HW, Findlay R, Waring AJ (1991). Antibodies against synthetic amphipathic helical sequences of surfactant protein SP-B detect a conformational change in the native protein. FEBS Lett 282:220-224.
17. 17. Traish AM, Netsuwan N (1994). Binding of 7α,17α-dimethyl-19-nortestosterone (Mibolerone) to progesterone receptors induced conformational changes different from those induced by ORG 2058. Steroids 59:362-370.
18. 18. Bidart JM, Troalen F, Ghillani P, Rouas N, Razafindratsita A, Bohuon C, Bellet D (1990). Peptide immunogen mimicry of a protein-specific structural epitope on human choriogonadotropin. Science 248:736-739.