Functional knockout of the corepressor CtBP by the second exon of adenovirus E1A relieves repression of transcription

Experimental Cell Research

Volumn 268, Issue 2, 2001, Pages 284-293

  Sundqvist, Anders ^a   Bajak, Edyta ^a   Kurup, Sindhulakshmi D ^a   Sollerbrant, Kerstin ^b   Svensson, Catharina ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; TRICHOSTATIN A;

ADENOVIRUS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL INTERACTION; EXON; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; VIRUS INHIBITION; VIRUS TRANSCRIPTION;

ADENOVIRIDAE;

EID: 0035881277     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5280     Document Type: Article

References (41)

1. A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis
2. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation
3. XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development
4. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3
5. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators
6. Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo
7. Interaction of shortrange repressors with Drosophila CtBP in the embryo
8. Drosophila CtBP: A Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression
9. A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription
10. Human Kruppel-like factor.8: A CACCC-box binding protein that associates with CtBP and represses transcription
11. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
12. Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors
13. C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins
14. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and deacetylation
15. Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif
16. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage
17. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
18. Nuclear localization and cell cyclespecific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor
19. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor
20. The CtBP binding domain in the adenovirus E1A protein controls CR1-dependent transactivation
21. The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex
22. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor
23. Structural determinants present in the C-terminal binding protein binding site of adenovirus early region 1A proteins
24. Adenovirus VA RNAI mediates a translational stimulation which is not restricted to the viral mRNAs
25. Transcription activation by the adenovirus E1a protein
26. A complex promoter element mediates transactivation of the human proliferating cell nuclear antigen promoter by the 243-residue adenovirus E1A oncoprotein
27. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
28. Tumour suppressive properties of the adenovirus 5 E1A oncogene
29. Retinoblastoma protein recruits histone deacetylase to repress transcription
30. Rb interacts with histone deacetylase to repress transcription
31. Molecular cloning and characterization of a novel retinoblastoma-binding protein
32. Control of histone modifications
33. The "dark side" of chromatin remodeling: Repressive effects on transcription
34. Sin meets NuRD and other tails of repression
35. Functional interactions within adenovirus E1A protein complexes
36. Adenovirus E1A proteins and transformation
37. Enhanced invasive properties of rat embryo fibroblasts transformed by adenovirus E1A mutants with deletions in the carboxy-terminal exon
38. Effectors for the Rho GTPases
39. While E1A can facilitate epithelial cell transformation by several dominant oncogenes, the C-terminus seems only to regulate rac and cdc42 function, but in both epithelial and fibroblastic cells
40. Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression