Physical and functional interactions between the corepressor CtBP and the Epstein-Barr virus nuclear antigen EBNA3C

Journal of Virology

Volumn 75, Issue 16, 2001, Pages 7749-7755

  Touitou, R ^a   Hickabottom, M ^a   Parker, G ^a   Crook, T ^a   Allday, M J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ASPARTIC ACID; DNA; EPSTEIN BARR VIRUS ANTIGEN; EPSTEIN BARR VIRUS ANTIGEN 3C; LEUCINE; PROLINE; SERINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CTBP; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA BINDING; EMBRYO; EPSTEIN BARR VIRUS; FIBROBLAST; GENE DELETION; GENE MUTATION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION;

ALCOHOL OXIDOREDUCTASES; ANIMALS; DNA-BINDING PROTEINS; EPSTEIN-BARR VIRUS INFECTIONS; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; HERPESVIRUS 4, HUMAN; HUMANS; PHOSPHOPROTEINS; PROTEIN BINDING; REPRESSOR PROTEINS; VIRUS REPLICATION;

EID: 0034910721     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.16.7749-7755.2001     Document Type: Article

References (37)

1. Epstein-Barr virus nuclear antigen 3C is a powerful repressor of transcription when tethered to DNA
2. A region in the C-terminus of adenovirus 2/5 Ela protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis
3. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and deacetylation
4. A transforming p53 mutant, which binds DNA, transactivates and induces apoptosis, reveals a nuclear:cytoplasmic shuttling defect
5. Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor dEF1
6. Molecular cloning and characterisation of a novel retinoblastoma-binding protein
7. The Rb/E2F pathway: Expanding roles and emerging paradigms
8. Immortalization of human B lymphocytes by a plasmid containing 71 kilobase pairs of Epstein-Barr virus DNA
9. Epstein-Barr virus and its replication
10. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
11. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
12. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage
13. Structural determinants present in the C-terminal binding protein binding site of adenovirus early region 1A proteins
14. Epstein-Barr virus nuclear antigen 3C is a transcriptional regulator
15. A mechanism for Rb/p 130-mediated transcription repression involving recruitment of the CtBP corepressor
16. dCtBP mediates transcriptional repression by Knirps, Kruppel and Snail in the Drosophila embryo
17. Interaction of short-range repressors with Drosophila CtBP in the embryo
18. Epstein-Barr nuclear antigen EBNA 3C is an immortalizing oncoprotein with similar properties to adenovirus E1A and papillomavirus E7
19. Epstein-Barr virus EBNA3C can disrupt multiple cell cycle checkpoints and induce nuclear division divorced from cytokinesis
20. Drosophila CtBP: A Hairy-interacting protein required for embryonic segmentation and Hairy-mediated transcriptional repression
21. ZEB represses transcription through interaction with the corepressor CtBP
22. Zfh-1, the Drosophila homologue of ZEB, is a transcriptional repressor that regulates somatic myogenesis
23. Growth factor induction by the adenovirus type 5 E1A 12S protein is required for immortalization of primary epithelial cells
24. Immortalization of primary epithelial cells requires first- and second-exon functions of adenovirus type 5 12S
25. Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21
26. Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription
27. Molecular cloning and characterisation of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in a negative modulation of oncogenic transformation
28. C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins
29. Enhanced ras oncogene mediated cell transformation amd tumorigenesis by adenovirus 2 mutants lacking the C-terminal region of E1A protein
30. The carboxy-terminal region of adenovirus E1A activates transcription through targeing of a C-terminal binding protein-histone deacetylase complex
31. Epstein-Barr nuclear proteins EBNA3A and EBNA3C are essential for B lymphocyte growth transformation
32. Cloning and characterisation of mCtBP2, a co-repressor that associates with basic Kruppel-like factors and other mammalian transcriptional regulators
33. Epstein-Barr virus EBNA3A and EBNA3C proteins both repress RBP-Jκ-EBNA2-activated transcription by inhibiting the binding of RBP-Jκ to DNA
34. Nuclear localisation and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor
35. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
36. Association of the COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor
37. Epstein-Barr virus nuclear antigen 3C activates the latent membrane promoter in the presence of Epstein-Barr virus nuclear antigen 2 through sequences encompassing an Spi1/SpiB binding site