Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators

EMBO Journal

Volumn 17, Issue 17, 1998, Pages 5129-5140

  Turner, Jeremy ^a   Crossley, Merlin ^a  

^a NONE

Author keywords

BKLF; CtBP; mCtBP2; Transcriptional repression; Zinc finger proteins

Indexed keywords

REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE REPRESSION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CLONING, MOLECULAR; DNA-BINDING PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OXIDOREDUCTASES; PHOSPHOPROTEINS; PROTEIN BINDING; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STEREOISOMERISM; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; ZINC FINGERS;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0032167456     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.17.5129     Document Type: Article

References (58)

1. Anderson, K.P., Kern, C.B., Crable, S.C. and Lingrel, J.B. (1995) Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family. Mol. Cell. Biol., 15, 5957-5965.
2. Bartel, P.L., Chien, C.-T., Sternglanz, R. and Fields, S. (1993) Using the two-hybrid system to detect protein-protein interactions. In Hartley, D.A. (ed.), Cellular Interactions in Development: A Practical Approach. Oxford University Press, Oxford, pp. 153-179.
3. Bartholomew, C., Kilbey, A., Clark, A.M. and Walker, M. (1997) The Evi-1 proto-oncogene encodes a transcriptional repressor activity associated with transformation. Oncogene, 14, 569-577.
4. Boyd, J.M., Subramanian, T., Schaeper, U., La Regina, M., Bayley, S. and Chinnadurai, G. (1993) A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. EMBO J., 12, 469-478.
5. Brehm, A., Miska, E.A., McCance, D.J., Reid, J.L., Bannister, A.J. and Kouzarides, T. (1998) Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature, 391, 597-601.
6. Broihier, H.T., Moore, L.A., Van Doren, M., Newman, S. and Lehmann, R. (1998) zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila. Development, 125, 655-666.
7. Chen, C. and Okayama, H. (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol., 7, 2745-2752.
8. Choo, Y., Sanchez-Garcia, I. and Klug, A. (1994) In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence. Nature, 372, 642-645.
9. Choo, Y., Castellanos, A., Garcia-Hernandez, B., Sanchez-Garcia, I. and Klug, A. (1997) Promoter-specific activation of gene expression directed by bacteriophage-selected zinc fingers. J. Mol. Biol., 273, 525-532.
10. Crossley, M., Whitelaw, E., Perkins, A., Williams, G., Fujiwara, Y. and Orkin, S.H. (1996) Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Mol. Cell. Biol., 16, 1695-1705.
11. Fan, C.M and Maniatis, T. (1989) Two different virus-inducible elements are required for human beta-interferon gene regulation. EMBO J., 8, 101-110.
12. Feng, W.C., Southwood, C.M. and Bieker, J.J. (1994) Analyses of β-thalassemia mutant DNA interactions with erythroid Krüppel-like factor (EKLF), an erythroid cell-specific transcription factor. J. Biol. Chem., 269, 1493-1500.
13. Fisher, A.L., Ohsako, S. and Caudy, M. (1996) The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol. Cell. Biol. 16, 2670-2677.
14. Garrett-Sinha, L.A., Eberspaecher, H., Seldin, M.F. and de Crombrugghe, B. (1996) A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J. Biol. Chem., 271, 31384-31390.
15. Geisberg, J.V., Chen, J.L. and Ricciardi, R.P. (1995) Subregions of the adenovirus E1A transactivation domain target multiple components of the TFIID complex. Mol. Cell. Biol., 15, 6283-6290.
16. Genetta, T., Ruezinsky, D. and Kadesch, T. (1994) Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: implications for B-cell specificity of the immunoglobulin heavy-chain enhancer. Mol. Cell. Biol., 14, 6153-6163.
17. Goldberg, J.D., Yoshida, T. and Brick, P. (1994) Crystal structure of a NAD-dependent D-glycerate dehydrogenase at 2.4 Å resolution. J. Mol. Biol., 236, 1123-1140.
18. Haenlin, M. Cubadda, Y., Blondeau, F., Heitzler, P., Lutz, Y., Simpson, P. and Ramain, P. (1997) Transcriptional activity of Pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila. Genes Dev., 11, 3096-3108.
19. Hanna-Rose, W. and Hansen, U. (1996) Active repression mechanisms of eukaryotic transcription repressors. Trends Genet., 12, 229-234.
20. Heery, D.M. Kalkhoven, E., Hoare, S. and Parker, M.G. (1997) A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature, 387, 733-736.
21. Hollenberg, S.M. Weinberger, C., Ong, E.S., Cerelli, G., Oro, A., Lebo, R., Thompson, E.B., Rosenfeld, M.G. and Evans, R.M. (1985) Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature, 318, 635-641.
22. Ikeda, K., Halle, J.P., Stelzer, G., Meisterernst, M. and Kawakami, K. (1998) Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6. Mol. Cell. Biol., 18, 10-18.
23. Iwabuchi, K., Li, B., Bartel, P. and Fields, S. (1993) Use of the two-hybrid system to identify the domain of p53 involved in oligomerization. Oncogene, 8, 1693-1696.
24. Katsanis, K. and Fisher, E.M.C. (1998) A novel C-terminal binding protein (CtBP2) is closely related to CtBP1, an adenovirus E1 A-binding protein and maps to human chromosome 21q21.3. Genomics, 47, 294-299.
25. Kim, J.S. and Pabo, C.O. (1997) Transcriptional repression by zinc finger peptides. Exploring the potential for applications in gene therapy. J. Biol. Chem., 272, 29795-29800.
26. Kim, J.S. and Pabo, C.O. (1998) Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants. Proc. Natl Acad. Sci. USA, 95, 2812-2817.
27. Kim, J.S., Kim, J., Cepek, K.L., Sharp, P.A. and Pabo, C.O. (1997) Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression. Proc. Natl Acad. Sci. USA, 94, 3616-3620.
28. Kuo, C.T., Veselits, M.L., Barton, K.P., Lu, M.M. Crendenin, C. and Leiden, J.M. (1997a) The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev., 11, 2996-3006.
29. Kuo, C.T., Veselits, M.L. and Leiden, J.M. (1997b) LKLF: a transcriptional regulator of single-positive T cell quiescence and survival. Science, 277, 1986-1990.
30. Lee, W.S., Kao, C.C., Bryant, G.O., Liu, X. and Berk, A.J. (1991) Adenovirus E1A activation domain binds the-basic repeat in the TATA box transcription factor. Cell, 67, 365-376.
31. Lin, R.J., Nagy, L., Inoue, S., Shao, W., Miller, W.H.,Jr and Evans, R.M. (1998) Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature, 391, 811-814.
32. Magnaghi-Jaulin, L., Groisman, R., Naguibneva, I., Robin, P., Lorain, S., Le Villain, J.P., Troalen, F. Trouche, D. and Harel-Bellan, A. (1998) Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature, 391, 601-605.
33. Merika, M. and Orkin, S.H. (1995) Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol. Cell Biol., 15, 2437-2447.
34. Miller, I.J. and Bieker, J.J. (1993) A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins. Mol. Cell. Biol., 13, 2776-2786.
35. Mitchell, P.J. and Tjian, R. (1989) Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science, 245, 371-378.
36. Morishita, K., Parker, D.S., Mucenski, M.L., Jenkins, N.A., Copeland, N.G. and Ihle, J.N. (1988) Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell, 54, 831-840.
37. Morishita, K., Suzukawa, K., Taki, T., Ihle, J.N. and Yokota, J. (1995) EVI-1 zinc finger protein works as a transcriptional activator via binding to a consensus sequence of GACAAGATAAGATAAN 1-28 CTCATCTTC. Oncogene, 10, 1961-1967.
38. Mymryk, J.S. (1996) Tumour suppressive properties of the adenovirus 5 E1A oncogene. Oncogene, 13, 1581-1589.
39. Nagy, L., Kao, H.Y., Chakravarti, D., Lin, R.J., Hassig, C.A., Ayer, D.E., Schreiber, S.L. and Evans, R.M. (1997) Nuclear receptor repression mediated by a complex containing SMRT, mSin3A and histone deacetylase. Cell, 89, 373-380.
40. Nibu, Y., Zhang, H. and Levine, M. (1998) Interaction of short-range repressors with Drosophila CtBP in the embryo. Science, 280, 101-104.
41. Nucifora, G. (1997) The EVI1 gene in myeloid leukemia. Leukemia, 11. 2022-2031.
42. Nuez, B., Michalovich, D., Bygrave, A., Ploemacher, R. and Grosveld, F. (1995) Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature, 375, 316-318.
43. Perkins, A.C. Sharpe, A.H. and Orkin, S.H. (1995) Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature, 375, 318-322.
44. Perkins, A.C., Yang, H., Crossley, P. Fujiwara, Y. and Orkin, S.H. (1997) Deficiency of the CACCC-element binding protein, BKLF, leads to a progressive myeloproliferative disease and impaired expression of SHP-1. Blood, 90, Suppl. 1, 575.
45. Poortinga, G., Watanabe, M. and Parkhurst, S.M. (1998) Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and Hairy-mediated transcriptional repression. EMBO J., 17, 2067-2078.
46. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
47. Schaeper, U., Boyd, J.M., Verma, S., Uhlmann, E., Subramanian, T. and Chinnadurai, G. (1995) Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc. Natl Acad. Sci. USA, 92, 10467-10471.
48. Schüle, R., Muller, M., Otsuka-Murakami, H. and Renkawitz, R. (1988) Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor. Nature, 332, 87-90.
49. Shields, J.M., Christy, R.J. and Yang, V.W. (1996) Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J. Biol. Chem., 271, 20009-20017.
50. Sollerbrant, K., Chinnadurai, G. and Svensson, C. (1996) The CtBP binding domain in the adenovirus E1A protein controls CR1-dependent transactivation. Nucleic Acids Res., 24, 2578-2584.
51. Strähle, U., Schmid, W. and Schütz, G. (1988) Synergistic action of the glucocorticoid receptor with transcription factors. EMBO J., 7, 3389-3395.
52. Taguchi, H. and Ohta, T. (1993) Histidine 296 is essential for the catalysis in Lactobacillus plantarum D-lactate dehydrogenase. J. Biol. Chem., 268, 18030-18034.
53. Tanaka, T., Mitani, K., Kurokawa, M., Ogawa, S., Tanaka, K., Nishida, J., Yazaki, Y. Shibata, Y. and Hirai, H. (1995) Dual functions of the AML1/ Evi-1 chimeric protein in the mechanism of leukemogenesis in t (3:21) leukemias. Mol. Cell. Biol., 15, 2383-2392.
54. Tsang, A.P., Visvader, J.E., Turner, C.A., Fujiwara, Y. Yu, C., Weiss, M.J., Crossley, M. and Orkin, S.H. (1997) FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell. 90, 109-119.
55. Watanabe, Y. Kawakami, K., Hirayama, Y. and Nagano, K. (1993) Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene. J. Biochem., 114, 849-855.
56. Yang, X.J., Ogryzko, V.V., Nishikawa, J., Howard, B.H. and Nakatani, Y. (1996) A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature, 382, 319-324.
57. Yet, S.F. et al. (1998) Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J. Biol. Chem., 273, 1026-1031.
58. Zamanian, M. and La Thangue, N.B. (1992) Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor. EMBO J., 11, 2603-2610.