dCtBP-dependent and -independent repression activities of the Drosophila Knirps protein

Molecular and Cellular Biology

Volumn 20, Issue 19, 2000, Pages 7247-7258

  Keller, S A ^a   Mao, Y ^a   Struffi, P ^a   Margulies, C ^a   Yurk, C E ^a   Anderson, A R ^a   Amey, R L ^a   Moore, S ^a   Ebels, J M ^a   Foley, K ^a   Corado, M ^a   Arnosti, D N ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; DNA BINDING; DROSOPHILA; EMBRYO DEVELOPMENT; ENHANCER REGION; GENE REPRESSION; GENE TARGETING; GENETIC REGULATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ANIMAL; BASE SEQUENCE; BINDING SITES; CELLS, CULTURED; CHIMERIC PROTEINS; COMPARATIVE STUDY; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; EMBRYO, NONMAMMALIAN; FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; INSECT PROTEINS; MACROMOLECULAR SYSTEMS; MALE; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION, GENETIC;

DROSOPHILA; DROSOPHILA MELANOGASTER;

EID: 0033830546     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.19.7247-7258.2000     Document Type: Article

References (55)

1. Multifunctional role of the Pitx2 homeodomain protein C-terminal tail
2. The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo
3. Groucho-dependent and -independent repression activities of Runt domain proteins
4. Solution structure of the DNA-binding domain of Cd2-GAL4 from S. cerevisiae
5. Hairy mediates dominant repression in the Drosophila embryo
6. XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development
7. Long-range repression in the Drosophila embryo
8. A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives
9. Drosophila Tcf and Groucho interact to repress Wingless signalling activity
10. The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development
11. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster
12. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation
13. Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor δEF1
14. Functional and conserved domains of the Drosophila transcription factor encoded by the segmentation gene knirps
15. Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2
16. Short-range repression permits multiple enhancers to function autonomously within a complex promoter
17. Transcriptional repression in the Drosophila embryo
18. Short-range transcriptional repressors mediate both quenching and direct repression within complex loci in Drosophila
19. Transcriptional repression in development
20. Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1)
21. Two evolutionarily conserved repression domains in the Drosophila Kruppel protein differ in activator specificity
22. Transcriptional repression by the Drosophila Giant protein: cis Element positioning provides an alternative means of interpreting an effector gradient
23. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
24. Active repression of transcription by the engrailed homeodomain protein
25. Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed
26. Characterization of the cooperative function of inhibitory sequences in Ets-1
27. The Drosophila dorsal morphogen represses the tolloid gene by interacting with a silencer element
28. Concentration-dependent patterning by an ectopic expression domain of the Drosophila gap gene knirps
29. Conservation of regulatory elements controlling hairy pair-rule stripe formation
30. Hairy stripe 7 element mediates activation and repression in response to different domains and levels of Kruppel in the Drosophila embryo
31. DNA binding by c-Ets-1, but not v-Ets, is repressed by an intramolecular mechanism
32. The knirps and knirps-related genes organize development of the second wing vein in Drosophila
33. The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo
34. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor
35. Abdominal segmentation of the Drosophila embryo requires a hormone receptor-like protein encoded by the gap gene knirps
36. dCtBP mediates transcriptional repression by Knirps, Kruppel and Snail in the Drosophila embryo
37. Interaction of short-range repressors with Drosophila CtBP in the embryo
38. Mutations affecting segment number and polarity in Drosophila
39. Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations
40. Drosophila CtBP: A Hairy-interacting protein required for embryonic segmentation and Hairy-mediated transcriptional repression
41. Independent repressor domains in ZEB regulate muscle and T-cell differentiation
42. From gradients to stripes in Drosophila embryogenesis: Filling in the gaps
43. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation
44. C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins
45. Mechanisms of segmental pattern formation in Drosophila melanogaster
46. Regulation of even-skipped stripe 2 in the Drosophila embryo
47. Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo
48. The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex
49. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
50. Two distinct types of repression domain in engrailed: One interacts with the groucho corepressor and is preferentially active on integrated target genes
51. Structure and function of transcriptional activation domains
52. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators
53. CNS midline enhancers of the Drosophila slit and Toll genes
54. A gap gene, hunchback, regulates the spatial expression of Ultrabithorax
55. Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo