Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53

Cancer Research

Volumn 57, Issue 21, 1997, Pages 4722-4726

  Hunt, Kelly K ^a   Deng, Jiong ^a   Liu, Ta Jen ^a   Wilson Heiner, Marcia ^a   Swisher, Stephen G ^a   Clayman, Gary ^a   Hung, Mien Chie ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; TRANSCRIPTION FACTOR E2F; VIRUS VECTOR;

ADENOVIRUS; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; GENE OVEREXPRESSION; GYNECOLOGIC CANCER; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL;

ADENOVIRIDAE; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CARRIER PROTEINS; CELL CYCLE PROTEINS; DNA FRAGMENTATION; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; FEMALE; FLOW CYTOMETRY; GENES, P53; GENES, RETINOBLASTOMA; GENETIC VECTORS; HUMANS; MUTATION; OVARIAN NEOPLASMS; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030813584     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Xu, G., Livingston, D. M., and Krek, W. Multiple members of the E2F transcription family are the products of oncogenes. Proc. Natl. Acad. Sci. USA, 92: 1357-1361, 1995.
2. Yamasaki, L., Jacks, T., Bronson, R., Goillot, E., Harlow, E., and Dyson, N. J. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell, 85: 537-548, 1996.
3. Field, S. J., Tsai, F-Y., Kuo, F., Zubiaga, A. M., Kaelin, W. G., Livingston, D. M., Orkin, S. H., and Greenberg, M. E. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell, 85: 549-561, 1996.
4. Yang, X-H., and Sladek, T. L. Overexpression of the E2F-1 transcription factor gene mediates cell transformation. Gene Expr., 4: 195-204, 1995.
5. Qin, X-Q., Livingston, D. M., Kaelin, W. G., and Adams, P. D. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA, 91: 10918-10922, 1994.
6. Chang, J. Y., Xia, W., Shao, R., Sorgi, F., Hortobagyi, G. H., Huang, L., and Hung, M-C. The tumor suppression activity of E1A in HER-2/neu-overexpressing breast cancer. Oncogene, 14: 561-568, 1997.
7. Shan, B., Farmer, A. A., and Lee, W-H. The molecular basis of E2F-1/DP-1-induced S-phase entry and apoptosis. Cell Growth Differ., 7: 689-697, 1996.
8. Kowalik, T. F., DeGregori, J., Schwarz, J. K., and Nevins, J. R. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol., 69: 2491-2500, 1995.
9. Krek, W., Xu, G., and Livingston, D. M. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S-phase checkpoint. Cell, 83: 1149-1158, 1995.
10. Hiebert, S. W., Packham, G., Strom, D. K., Haffner, R., Oren, M., Zambetti, G., and Cleveland, J. L. EwF-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis. Mol. Cell. Biol., 15: 6864-6874, 1995.
11. Wu, X., and Levine, A. J. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA, 91: 3602-3606, 1994.
12. O'Connor, D. J., Lam, E. W-F., Griffin, S., Zhong, S., Leighton, L. C., Brugidge, S. A., and Lu, X. Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1. EMBO J., 14: 6184-6192, 1995.
13. Bargou, R. C., Wagener, C., Bommert, K., Arnold, W., Daniel, P. T., Mapara, M. Y., Grinstein, E., Royer, H. D., and Dörken, B. Blocking of transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice. J. Exp. Med., 183: 1205-1213, 1996.