Protease activated receptor 2 and the cardiovascular system

British Journal of Pharmacology

Volumn 135, Issue 1, 2002, Pages 14-20

  Cicala, Carla ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Blood pressure; Cardiovascular; Endothelial cells; Factor Xa; PAR2; Smooth muscle; Trypsin; Tryptase

Indexed keywords

BLOOD PRESSURE REGULATION; CARDIOVASCULAR SYSTEM; CELL PROLIFERATION; ENDOTHELIUM CELL; ENZYME MECHANISM; HEART MUSCLE ISCHEMIA; HUMAN; HYPOTENSION; IN VIVO STUDY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR SENSITIVITY; RESTENOSIS; REVIEW; SEPTIC SHOCK; SPECIES DIFFERENCE; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION;

EID: 0036152709     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704438     Document Type: Review

References (54)

1. Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2
2. Detection of functional receptors for the proteinase-activated receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle
3. Xa receptor EPR-1
4. Ligand cross-reactivity within the protease activated receptor family
5. Modulators of coagulation. A critical appraisal of their role in sepsis
6. Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2)
7. Factor Xa activates endothelial cells by a receptor cascade between EPR1 and PAR2
8. 2+ oscillations in madine-darby canine kidney cells only when proteolitically active
9. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
10. Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode
11. Receptor activating peptides distinguish thrombin receptor (PAR1) and protease activated receptor 2 (PAR-2) mediated hemodynamic responses in vivo
12. Protease-activated receptor-2 mediates proliferative responses in skeletal myoblasts
13. Linkage between inflammation and coagulation: An update on the molecular basis of the cross talk
14. Protease-activated receptor-2 involvement in hypotension in normal and endotoxemic rats in vivo
15. Pharmacological dissection of vascular effects caused by activation of protease-activated receptor 1 and 2 in anesthetized rats
16. Inflammation-coagulation network: Are serine protease receptors the knot?
17. Increased expression of protease activated receptor-2 (PAR-2) in balloon-injured rat carotid artery
18. Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1
19. Characterization of protease activated receptor-2 immunoreactivity in normal human tissues
20. A molecular mechanism for signaling between seven transmembrane receptors: Evidence for a redistribution of G proteins
21. Proteinase-activated receptors: Novel mechanisms of signalling by serine proteases
22. Vascular effects of proteinase activated receptor 2 agonist peptide
23. Identification of potential activators of proteinase activated receptor-2
24. Coagulation factor X. Xa, and protein S as potent mitogens of cultured aortic smooth muscle cells
25. Heterogenous mechanisms of endothelium-dependent relaxation for thrombin and peptide activators of protease-activated receptor-1 in porcine isolated coronary artery
26. Increased expression of protease-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists
27. Effector protease receptor 1 mediates the mitogenic activity of factor Xa for vascular smooth muscle cells in vitro and in vivo
28. Proteinase activated receptor-2 in rat aorta: Structural requirements for agonist activity of receptor-activating peptides
29. Protease-activated receptors: PAR4 and counting: How long is the course?
30. Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells
31. Mast cell distribution, activation, and phenotype in atherosclerotic lesions of human carotid arteries
32. Factor Xa-evoked relaxation in rat aorta: Involvement of PAR2
33. Coagulation factor Xa stimulates platelet-derived growth factor release and mitogenesis in cultured vascular smooth muscle cells of rat
34. The involvement of a novel mechanism distinct from the thrombin receptor in the vasocontraction induced by trypsin
35. Protease activated receptors modulate aortic vascular tone
36. The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells
37. Endothelium-dependent and independent responses to protease-activated receptor-2 (PAR-2) activation in mouse isolated renal arteries
38. Interactions of mast cell tryptase with thrombin receptors and PAR-2
39. Differential expression of functional protease-activated-receptor-2 (PAR-2) in human vascular smooth muscle cells
40. Vascular actions of thrombin receptor peptide
41. Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart
42. Molecular cloning of a potential proteinase activated receptor
43. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor
44. Thrombin responses in human endothelial cells
45. Protective effects of urinary trypsin inhibitor in experimental shock
46. A therapeutic effect of ulinastatin on endotoxin-induced shock in dogs-comparison with methylprednisolone
47. Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling
48. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor
49. Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: Evidence for receptor heterogeneity
50. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue
51. Endothelium-dependent contractile actions of proteinase-activated receptor-2 activating peptides in human umbilical vein: Release of a contracting factor via a novel receptor
52. Activation of protease activated receptor-2 (PAR-2) elicits nitric oxide-dependent dilatation of the basilar artery in vivo
53. Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease activated receptor-2 activation
54. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation