Inflammation-coagulation network: Are serine protease receptors the knot?

Trends in Pharmacological Sciences

Volumn 21, Issue 5, 2000, Pages 170-172

  Cirino, Giuseppe ^a   Napoli, Claudio ^b   Bucci, Mariarosaria ^a   Cicala, Carla ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIRULOG; N(G) NITROARGININE METHYL ESTER; PROTEINASE ACTIVATED RECEPTOR 1; SERINE PROTEINASE; THROMBIN; THROMBIN RECEPTOR;

ASTHMA; ATHEROSCLEROSIS; BLOOD CLOTTING; EDEMA; HUMAN; INFLAMMATION; MAST CELL; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE; SHORT SURVEY; THROMBOCYTE ACTIVATION; TISSUE REPAIR;

EID: 0034194405     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01469-3     Document Type: Note

References (21)

1. Cicala C., Cirino G. Linkage between inflammation and coagulation: an update on the molecular basis of the cross talk. Life Sci. 62:1998;1817-1824.
2. Dery O.et al. Protease activated receptors: novel mechanisms of signalling by serine proteases. Am. J. Physiol. 274:1999;C1429-C1452.
3. Cirino G.et al. Thrombin functions as an inflammatory mediator through activation of its receptor. J. Exp. Med. 183:1996;821-827.
4. Vergnolle N.et al. Pro- and anti-inflammatory actions of thrombin: a distinct role for proteinase activated receptor-1. Br. J. Pharmacol. 126:1999;1262-1268.
5. Cocks T.M., Moffat J.D. Protease-activated receptors: sentries for inflammation? Trends Pharmacol. Sci. 21:2000;103-108.
6. Fuchs-Buder T.et al. Time course of procoagulant activity and D dimer in bronchoalveolar fluid of patients at risk for or with acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 153:1996;163-167.
7. Cicala C.et al. Bronchocostrictor effect of thrombin receptor activating peptide in guinea pig in vivo. Br. J. Pharmacol. 126:1999;478-484.
8. Cocks T.M.et al. A protective role for protease activated receptor in the airways. Nature. 398:1999;156-160.
9. Kahn M.L.et al. Protease-activated receptor-1 and 4 mediate activation of human platelets by thrombin. J. Clin. Invest. 103:1999;879-887.
10. Nystedt S.et al. The proteinase activated receptor-2 is induced by inflammatory mediators in human endothelial cells: comparison with the thrombin receptor. J. Biol. Chem. 271:1996;14910-14915.
11. Cicala C.et al. Protease activated receptor-2 involvement in hypotension in normal and endotoxemic rats in vivo. Circulation. 99:1999;2590-2597.
12. Vergnolle N.et al. Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. Br. J. Pharmacol. 127:1999;1083-1090.
13. Vergnolle N. Proteinase activated receptor-2 activating peptides induce leukocyte rolling, adhesion and extravasation in vivo. J. Immunol. 163:1999;5064-5069.
14. Steinhoff M.et al. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat. Med. 6:2000;151-158.
15. Ambrosini G., Altieri D.C. Molecular dissection of effector cell protease receptor-1 recogntion of Factor Xa. Assignment of critical residues implicated in antibody and ligand binding. J. Biol. Chem. 271:1996;1243-1248.
16. Cirino G.et al. Factor Xa as interface between coagulation and inflammation. Molecular mimicry of Factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo. J. Clin. Invest. 99:1997;2446-2451.
17. Papapetropoulos A.et al. Hypotension and inflammatory cytokine gene expression triggered by Factor Xa-nitric oxide signaling. Proc. Natl. Acad. Sci. U. S. A. 95:1998;4738-4742.
18. Ross R. Atherosclerosis as inflammatory disease. New Engl. J. Med. 340:1999;115-126.
19. Napoli C.et al. Influence of maternal hypercholesterolemia during pregnancy on progression of early atherosclerotic lesions in childhood: fate of early lesions in children (FELIC) study. Lancet. 354:1999;1241-1243.
20. Nelken N.A.et al. Thrombin receptor expression in normal and human atherosclerotic human arteries. J. Clin. Invest. 90:1992;1614-1621.
21. Lou X.J.et al. Fibrinogen deficiency reduces vascular accumulation of apoliprotein (a) and development of atherosclerosis in apoliprotein (a) transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 95:1998;12591-12595.