Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and TAL-1 (SCL)

Blood

Volumn 89, Issue 7, 1997, Pages 2276-2282

  Lowsky, Robert ^b   DeCoteau, John F ^b   Reitmair, Armin H ^b   Ichinohasama, Ryo ^b   Dong, Wei Feng ^b   Xu, Yi ^b   Mak, Tak W ^b   Kadin, Marshall E ^b   Minden, Mark D ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASE MISPAIRING; CARCINOGENESIS; CONTROLLED STUDY; DNA REPAIR; EXON; GENE EXPRESSION; GENE MUTATION; HISTOPATHOLOGY; HOMOZYGOSITY; LYMPHOBLASTOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; SEQUENCE ANALYSIS; T CELL LYMPHOMA;

EID: 0030982907     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.7.2276     Document Type: Article

References (35)

1. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61:759, 1990
2. Bodmer W, Bishop T, Karran P: Genetic steps in colorectal cancer. Nature Genet 6:217, 1994
3. Loeb LA: Microsatellite instability: Marker of a mutator phenotype. Cancer Res 54:5059, 1994
4. Strand M, Prolla TA, Liskay RM, Petes TD: Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365:274, 1993
5. Papadopolous N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F, D'Arrigo A, Markowitz S, Willson JKV, Kinzler KW, Jirincny J, Vogelstein B: Mutations of GTBP in genetically unstable cells. Science 268:1915, 1995
6. Papadopolous N, Nicolaides NC, Wei Y-F, Ruben SM, Carter KC, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Hamilton SR, Petersen GM, Watson P, Lynch HT, Peltomaki P, Mecklin J-P, de la Chapelle A, Kinzer KW, Vogelstein B: Mutation of a mutL homolog in hereditary colon cancer. Science 263:1625, 1994
7. Fishel R, Lescoe MK, Rao MRS, Copeland NG, Jenkins NA, Garber J, Kane M, Kolodner R: The human mutator gene MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75:1027, 1993
8. Liu B, Parsons R, Hamilton SR, Peterson GM, Lynch HT, Watson P, Markowitz S, Willson JKV, Green J, de la Chapelle A, Kinzler K, Vogelstein B: hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. Cancer Res 54:4590, 1994
9. Wooster R, Cleton-Jansen A-M, Collins N, Mangion J, Cornelis RS, Cooper CS, Gusterson BA, Ponder BAJ, von Deimling A, Wiester OD, Cornelisse CJ, Devilee P, Stratton MR: Instability of short tandem repeats (microsatellites) in human cancers. Nature Genet 6:152, 1994
10. Ionov Y, Peinado MA, Malkbosyan S, Shibata D, Perucho M: Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonie carcinogenesis. Nature 363:558, 1993
11. Umar A, Boyer JC, Thomas DC, Nguyen DC, Risinger JI, Boyd J, Ionov Y, Perucho M, Kunkel TA: Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem 269:14367, 1994
12. Boyer JC, Umar A, Risinger JI, Lipford JR, Kane M, Yin S. Barrett C, Kolodner RD, Kunkel TA: Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res 55:6063, 1995
13. Liu B, Nicolaides NC, Markowitz S, Willson JKV, Parsons RE, Jen J, Papadopolous N, Peltomaki P, de la Chapelle A, Hamilton SR, Kinzler K, Vogelstein B: Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nature Genet 9:48, 1995
14. Reitmair AH, Schmits R, Ewel A, Bapat B, Redston M, Mitri A, Waterhouse P, Mittrucker HW, Wakeman A, Liu B, Thomason A, Griesser H, Gallinger S, Ballhausen WG, Fishel R, Mak TW: MSH2 deficient mice are viable and susceptible to lymphoid tumors. Nature Genet 11:64, 1995
15. de Wind N, Dekker M, Berns A, Radman M, te Riele H: Inactivation of the mouse MSH2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 82:321, 1995
16. Cline MJ: The molecular basis of leukemia. N Engl J Med 330:328, 1994
17. Bash R, Hall S, Timmons CF, Crist WM, Amylon M, Smith RG, Baer R: Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study. Blood 86:666, 1995
18. Weiss L, Bindl JM, Picozzi VJ, Link MP, Warnke RA: Lymphoblastic lymphoma: An immunophenotype study of 26 cases with comparison to T cell acute lymphoblastic leukemia. Blood 67:474, 1986
19. Neale GAM, Mao S, Parham DM, Murty KG Goorha RM: Expression of the proto-oncogene rhombotin-2 is identical to the acute phase response protein metallothionine, suggesting multiple functions. Cell Growth Diff 6:587, 1995
20. Ferrick DA, Sambhara SR, Ballhausen W, Iwamoto A, Pircher H, Walker CL, Yokoyama WM, Miller RG, Mak TW: T cell function and expression are dramatically altered in T cell receptor Vγ1.1Jγ4Cγ4 transgenic mice. Cell 57:483, 1989
21. Caccia N, Kronenberg M, Saxe D, Haars R, Bruns GAP, Goverman J, Malissen M, Willard H, Yoshikai Y, Simon M, Hood L, Mak TW: The T cell receptor beta chain genes are located on chromosome 6 in mice and chromosome 7 in humans. Cell 37:1091, 1984
22. Bentolila LA, d'Andon MF, Nguyen QT, Martinez Q, Rougeon F, Doyen N: The two isoforms of mouse deoxynucleotidyl transferase differ in both the ability to add N regions and subcellular localization. EMBO J 14:4221, 1995
23. Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomaki P, Sistonen P, Aaltonen LA, Nystrom-Lahti M, Guan X-Y, Zhang J, Meltzer PS, Yu J-W, Kao F-T, Chen DJ, Cerosaletti KM, Fournier REK, Todd S, Lewis T, Leach RJ, Naylor SL, Weissenbach J, Mecklin J-P, Jarvinen H, Petersen GM, Hamilton SR, Green J, Jass J, Watson P, Lynch HT, Trent JM, de la Chapelle A, Kinzler KW, Vogelstein B: Mutations of mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75:1215, 1993
24. Reenan RAG, Kolodner RD: Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins. Genetics 132:963, 1992
25. Burks RT, Kessis TD, Cho KR, Hedrick L: Microsatellite instability in endometrial carcinoma. Oncogene 9:1163, 1994
26. Han HJ, Yanagisawa A, Kato Y, Park JG, Nakamura Y: Genetic instability in pancreatic cancer and poorly differentiated gastric cancer. Cancer Res 53:5087, 1993
27. Robledo, M, Martinez B, Arranz E, Trujillo MJ, Gonzalez Ageitos A, Rivas C, Benitez J: Genetic instability of microsatellites in hematological neoplasms. Leukemia 9:960, 1995
28. Wijnen, J, Vasen H, Khan PM, Menko FH, van der Klift H, van Leeuwen C, van den Broek M, van Leeuwen-Cornelisse I, Nagengast F, Meijers-Heijboer A, Lindout D, Griffioen G, Cats A, Kleibeuker J, Varesco L, Bertario L, Bisgaard ML, Mohr J, Fodde R: Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis. Am J Hum Genet 56:1060, 1995
29. Brentnall TA, Rubin CE, Crispin DA, Stevens A, Batchelor RH, Haggitt RC, Bronner MP, Evans JP, McCahill LE, Bilir N, Boland CR, Rabinovitch PS: A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis. Gastroenterology 109:151, 1995
30. Eagle LR, Yin X, Brothman AR, Williams BJ, Atkin NB, Prochownik EV: Mutation of the MXI1 gene in prostate cancer. Nature Genet 9:249, 1995
31. Kazazian HH, Boehm CD: Molecular basis and prenatal diagnosis of β-thalassemia. Blood 72:1107, 1988
32. Donehower LA, Harvey M, Slagle BL, MacArthur MJ, Montgomery CA, Butel JS, Bradley A: Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356:215, 1992
33. Larson RC, Lavenir I, Larson TA, Baer R, Warren AJ, Wadman I, Nottage K, Rabbitts TH: Protein dimerization between Lmo2 (rbtn 2) and Tal 1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. EMBO J 15:1021, 1996
34. - lymphocytes in the thymus and T-cell tumors in transgenic mice. Blood 86:3060, 1995
35. Robb L, Rasko JEJ, Bath ML, Strasser A, Begley CG: scl, a gene frequently activated in human T cell leukaemia, does not induce lymphomas in transgenic mice. Oncogene 10:205, 1995