Mitochondrial involvement in acute neurodegeneration

IUBMB Life

Volumn 52, Issue 3-5, 2001, Pages 247-254

  Wieloch, T ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; DNA FRAGMENT; FREE RADICAL; OXIDIZING AGENT; PROTEINASE;

APOPTOSIS; BRAIN ISCHEMIA; CALCIUM TRANSPORT; DNA STRAND BREAKAGE; ENZYME ACTIVATION; HYPOGLYCEMIA; MITOCHONDRION; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; RESPIRATORY CHAIN; REVIEW; SIGNAL TRANSDUCTION;

EID: 0036138822     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540152846064     Document Type: Review

References (71)

1. Pathophysiology and treatment of focal cerebral ischaemia. Part I: Pathophysiology
2. Hypoglycemic brain injury in the rat. Correlation of density of brain damage with the EEG isoelectric time: A quantitative study
3. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
4. Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat
5. Neurodegeneration in excitotoxicity, global cerebral ischaemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis
6. Neuronal cell death: A demise with different shapes
7. Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischaemia
8. Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischaemia: Evidence against programmed cell death
9. DNA fragmentation follows delayed neuronal death in CA1 neurons exposed to transient global ischaemia in the rat
10. The density and distribution of ischaemic brain injury in the rat following 2-10 min of forebrain ischaemia
11. Rodent models of cerebral ischaemia
12. Transient and permanent resolution of ischaemic lesions on diffusion-weighted imaging after brief periods of focal ischaemia in rats: Correlation with histopathology
13. Thresholds in cerebral ischaemia - The ischaemic penumbra
14. Perfusion thresholds in human cerebral ischaemia: Historical perspective and therapeutic implications
15. Characterization of cortical depolarisations evoked in focal cerebral ischaemia
16. Spreading depression is not associated with neuronal injury in the normal brain
17. Temporal evolution of regional energy metabolism following focal cerebral ischaemia in the rat
18. Calcium: Still center-stage in hypoxic-ischaemic neuronal death
19. 2+ release from mitochondria
20. Mitochondrial control of cell death
21. Pathobiology of ischaemic stroke: An integrated view
22. Pathophysiology and treatment of focal cerebral ischaemia. Part II: Mechanisms of damage and treatment
23. Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart
24. Reactive oxygen radicals in signaling and damage in the ischaemic brain
25. Mitochondria and neuronal survival
26. Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats
27. The biochemistry of apoptosis
28. Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells
29. Mitochondria and cell death
30. The mitochondrial permeability transition
31. The mitochondrial permeability transition: Its molecular mechanism and role in reperfusion injury
32. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
33. Apoptosis after experimental stroke: Fact or fashion?
34. Neuron-specific transgene expression of Bcl-XL but not Bcl-2 genes reduced lesion size after permanent middle cerebral artery occlusion in mice
35. Targeted disruption of the bcl-2 gene in mice exacerbates focal ischaemic brain injury
36. Expression of bcl-2 from a defective herpes simplex virus-I vector limits neuronal death in focal cerebral ischaemia
37. Early immunohistochemical changes of microtubule based motor proteins in gerbil hippocampus after transient ischaemia
38. Intracellular Bax translocation after transient cerebral ischaemia: Implications for a role of the mitochondrial apoptotic signaling pathway in ischaemic neuronal death
39. Cytosolic redistribution of cytochrome c after transient focal cerebral ischaemia in rats
40. Survival-and death-promoting events after transient cerebral ischaemia: Phosphorylation of Akt, release of cytochrome C and activation of caspase-like proteases
41. Elevation of neuronal expression of NAIP reduces ischaemic damage in the rat hippocampus
42. Cell signaling in ischaemic neuronal death
43. MEKI protein kinase inhibition protects against damage resulting from focal cerebral ischaemia
44. Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischaemia
45. Transduction of survival signals in neurons-take your PIK?
46. Apoptosis in the nervous system
47. Alterations of Aktl (PKBalpha) and p70(S6K) in transient focal ischaemia
48. 2+-induced apoptosis through calcineurin dephosphorylation of BAD
49. 2+activated cell death in mammalian cells
50. Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia
51. Cyclosporin A protects against ischaemia-reperfusion injury in the brain
52. Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat
53. Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death
54. Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion
55. Apoptotic biochemical cascades in synaptic compartments: Roles in adaptive plasticity and neurodegenerative disorders
56. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischaemia
57. Attenuation of delayed neuronal death after mild focal ischaemia in mice by inhibition of the caspase family
58. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischaemia
59. Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat
60. CD95 ligand (Fas-L/APO-IL) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischaemia-induced apoptosis in neurons
61. Cross-talk between two cysteine protease families. Activation of caspase- 12 by calpain in apoptosis
62. Lysosomal protease pathways to apoptosis: Cleavage of bid, not Pro-caspases, is the most likely route
63. Implication of cysteine proteases calpain, cathepsin and caspase in ischaemic neuronal death of primates
64. Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: A novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'
65. The mitochondrion in cell death control: Certainties and incognita
66. Cerebral ischaemia produces laddered DNA fragments distinct from cardiac ischaemia and archetypal apoptosis
67. The time-course of DNA fragmentation in the choroid plexus and the CA1 region following transient global ischaemia in the rat brain. The effect of intra-ischaemic hypothermia
68. Defying death after DNA damage
69. Surfing the p53 network
70. Aggravation of brain injury after transient focal ischaemia in p53-deficient mice
71. The tumor suppressor p53 and its response gene p21WAF1/Cip1 are not markers of neuronal death following transient global cerebral ischaemia