Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat

Neuroscience Letters

Volumn 213, Issue 2, 1996, Pages 111-114

  Van Lookeren Campagne, Menno ^a   Gill, Ramanjit ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Apoptosis; Cell death; Development; Endonuclease; Ischaemia; N Methyl D aspartate; Necrosis

Indexed keywords

DNA FRAGMENT; N METHYL DEXTRO ASPARTIC ACID;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT; ULTRASTRUCTURE;

EID: 0030565010     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12839-1     Document Type: Article

References (23)

1. [1] Clarke, P.G.H., Developmental cell death: morphological diversity and multiple mechanisms, Anat. Emryol., 181 (1990) 195-213.
2. [2] Garcia, J.H., Liu, K.F. and Ho, K.L., Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudatoputamen and the cortex, Stroke, 26 (1995) 636-643.
3. [3] Gavrieli, Y., Sherman, Y. and Ben-Sasson, S.A., Identification of programmed cell death in situ via specific labelling of DNA nuclear fragmentation, J. Cell Biol., 119 (1992) 493-501.
4. [4] Gill, R., Sibson, N.R., Hatfield, R.H., Burdett, N.G., Carpenter, T.A., Hall, L.D. and Pickard, J.D., A comparison of the early development of ischemic damage following permanent middle cerebral artery occlusion in rats as assessed using magnetic resonance imaging and histology, J. Cerebral Blood Flow. Metab., 15 (1995) 1-11.
5. [5] González-Martin, C., de Diego, I., Crespo, D. and Fairén, A., Transient c-fos expression accompanies naturally occurring cell death in the developing interhemispheric cortex of the rat, Dev. Brain Res., 68 (1992) 83-95.
6. [6] Grasl-Kraupp, B., Ruttkay-Nedecky, B., Koudelka, H., Bukowska, K., Bursch, W. and Schulte-Hermann, R., In Situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis and autolytic cell death: a cautionary note, Hepatology, 21 (1995) 1465-1468.
7. [7] Hatfield, R.H., Gill, R. and Brazell, C., The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischemia model, Eur. J. Pharmacol., 216 (1992) 1-7.
8. [8] Kerr, J.F.R., Wyllie, A.H. and Currie, A.R., Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, Br. J. Cancer, 26 (1972) 239-257.
9. [9] Levin, S., A toxicological pathologist's view of apoptosis or I used to call it necrobiosis, but now I'm singing the apoptosis blues, Toxicol. Pathol., 23 (1995) 533-539.
10. [10] Li, Y., Chopp, M., Jiang, N., Yao, F. and Zaloga, C., Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat, J. Cerebral Blood Flow. Metab., 15 (1995) 389-397.
11. [11] Li, Y., Sharov, V., Jiang, N., Zaloga, C., Sabbah, H.N. and Chopp, M., Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat, Am. J. Pathol., 146 (1995) 1045-1051.
12. [12] Linnik, M.D., Miller, J.A., Spinkle-Cavallo, J., Mason, P.J., Thompson, F.Y., Montgomery, L.R. and Schroeder, K.K., Apoptotic DNA fragmentation in the rat cerebral cortex induced by permanent middle cerebral artery occlusion, Mol. Brain Res., 32 (1995) 116-124.
13. [13] Linnik, M.D., Zobrist, R.H. and Hatfield, M.D., Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats, Stroke, 24 (1993) 2002-2009.
14. [14] Lucassen, P.J., Chung, W.C.J., Vermeulen, J.P., Van Lookeren Campagne, J.P., Van Dierendonck, J.H. and Swaab, D.F., Microwave enhanced in situ end-labelling of fragmented DNA; parametric studies in relation to postmortem delay and fixation of rat and human brain, J. Histochem. Cytochem., 43 (1995) 1163-1171.
15. [15] MacManus, J.P., Hill, I.E., Huang, Z.-G., Rasquinha, I., Xue, D. and Buchan, A.M., DNA damage consistent with apoptosis in transient focal ischemic neocortex, NeuroReport, 5 (1994) 493-496.
16. [16] McDonald, J.W., Silverstein, F.S. and Johnston, M.V., Neurotoxicity of N-methyl-d-aspartate is markedly enhanced in developing rat central nervous system,. Brain Res., 459 (1988) 200-203.
17. [17] Oppenheim, R.W., Cell death during development of the nervous system, Annu. Rev. Neurosci., 14 (1991) 453-501.
18. [18] Portera-Cailliau, C., Hedreen, J.C., Price, D.L. and Koliatos, E., Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models, J. Neurosci., 15 (1995) 3776-3787.
19. [19] Sloviter, R.S., Dean, E., Sollas, A.L. and Goodman, J.H., Apoptosis and necrosis induced in different hippocampal neuron populations by repetitive perforant path stimulation in the rat, J. Comp. Neurol., 366 (1996) 516-533.
20. [20] Tominaga, T., Kure, S. and Yoshimoto, T., DNA fragmentation in focal cortical freeze injury of rats, Neurosci. Lett., 139 (1992) 265-268.
21. [21] Van Lookeren Campagne, M., Lucassen, J.P., Vermeulen, J.P. and Balazs, R., NMDA and kainate induce internucleosomal DNA fragmentation associated with both apoptotic and necrotic cell death in the neonatal rat brain, Eur. J. Neurosci., 7 (1995) 1627-1640.
22. [22] Wyllie, A.H., Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation, Nature, 284 (1980) 555-556.
23. [23] Wyllie, A.H., Kerr, J.F.R. and Currie, A.R., Cell death: the significance of apoptosis, Int. Rev. Cytol., 68 (1980) 251-306.