Aggravation of brain injury after transient focal ischemia in p53-deficient mice

Molecular Brain Research

Volumn 88, Issue 1-2, 2001, Pages 54-61

  Maeda, Keiichiro ^a   Hata, Ryuji ^a   Gillardon, Frank ^a   Hossmann, Konstantin Alexander ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

Apoptosis; Cerebral ischemia; Mutant mouse; p53; Stroke

Indexed keywords

ADENOSINE TRIPHOSPHATE; BRAIN PROTEIN; DNA FRAGMENT; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; COLOR ULTRASOUND FLOWMETRY; CONTROLLED STUDY; DNA STRAND BREAKAGE; DOSE RESPONSE; METABOLIC DISORDER; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NICK END LABELING; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEFECT;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR CIRCULATION; ENERGY METABOLISM; HETEROZYGOTE; HOMOZYGOTE; IN SITU NICK-END LABELING; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; LASER-DOPPLER FLOWMETRY; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; TUMOR SUPPRESSOR PROTEIN P53;

VIOLA (ANGIOSPERM);

EID: 0035977977     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(01)00017-1     Document Type: Article

References (41)

1. Comparative analysis of brain proteins from p53-deficient mice by two-dimensional electrophoresis
2. The intraischemic and early reperfusion changes of protein synthesis in the rat brain. eIF-2 alpha kinase activity and role of initiation factors eIF-2 alpha and eIF-4E
3. Cell cycle-related gene expression in the adult rat brain: Selective induction of cyclin G1 and p21(WAF1/CIP1) in neurons following focal cerebral ischemia
4. Role of oxidants in ischemic brain damage
5. Zfm1/sf1 mRNA in rat and gerbil brain after global ischaemia
6. Dorsal cerebral arterial collaterals of the rat
7. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice
8. Double-stranded RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53
9. Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha
10. Very delayed infarction after mild focal cerebral ischemia: A role for apoptosis?
11. Antioxidants, oxidative stress, and degenerative neurological disorders
12. The evolution of brain infarcts - A review
13. p53: DNA damage, DNA repair, and apoptosis
14. Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury
15. Evolution of brain infarction after transient focal cerebral ischemia in mice
16. A reproducible model of middle cerebral artery occlusion in mice: Hemodynamic, biochemical, and magnetic resonance imaging
17. Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system
18. A pictorial representation of endogenous brain ATP by a bioluminescent method
19. Experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area
20. Apoptosis, excitotoxicity, and neuropathology
21. The role of p53 as a tumor suppressor in human cancers
22. p53, the cellular gatekeeper for growth and division
23. Apoptosis and protein expression after focal cerebral ischemia in rat
24. p53-immunoreactive protein and p53 messenger RNA expression after transient middle cerebral artery occlusion in rats
25. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia
26. Ischemic cell death in brain neurons
27. Differences in the cerebrovascular anatomy of C57Black/6 and SV129 mice
28. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
29. Hippocampal myc and p53 expression following transient global ischemia
30. Ischemic thresholds of cerebral protein synthesis and energy state following middle cerebral artery occlusion in rats
31. Up-regulation of c-myc gene expression following focal ischemia in the rat brain
32. Cyclin-dependent kinases as a therapeutic target for stroke
33. Threshold relationship between cerebral blood flow, glucose utilization, and energy metabolites during development of stroke in gerbils
34. Apoptosis in neurological disease
35. Pixel-based image analysis of HSP70, GADD45, and MAP2 mRNA expression after focal cerebral ischemia: Hemodynamic and histological correlates
36. A semiautomated method for measuring brain infarct volume
37. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
38. Changes in proliferating cell nuclear antigen, a protein involved in DNA repair, in vulnerable hippocampal neurons following global cerebral ischemia
39. Activation of p53 and its target genes p21(waf1/cip1) and pag608/wig-1 in ischemic preconditioning
40. Increase in p53 protein expression following cortical infarction in the spontaneously hypertensive rat
41. Cyclin D1 messenger RNA is induced in microglia rather than neurons following transient forebrain ischaemia