Two antigenic peptides from genes m123 and m164 of murine cytomegalovirus quantitatively dominate CD8 T-cell memory in the H-2d haplotype

Journal of Virology

Volumn 76, Issue 1, 2002, Pages 151-164

  Holtappels, R ^a   Thomas, D ^a   Podlech, J ^a   Reddehase, M J ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VIRUS PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ARTICLE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOLOGICAL MEMORY; IMMUNOTHERAPY; LUNG INFILTRATE; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE;

ANIMALS; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; H-2 ANTIGENS; HAPLOTYPES; HERPESVIRIDAE INFECTIONS; IMMEDIATE-EARLY PROTEINS; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED BALB C; MUROMEGALOVIRUS; OPEN READING FRAMES; PEPTIDE FRAGMENTS; PHOSPHOPROTEINS; SPLEEN; VIRAL MATRIX PROTEINS; VIRAL PROTEINS;

EID: 0036132831     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.1.151-164.2002     Document Type: Article

References (68)

1. Control of cytomegalovirus in bone marrow transplantation chimeras lacking the prevailing antigenpresenting molecule in recipient tissues rests primarily on recipient-derived CD8 T cells
2. CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes
3. + T-cell response is much less apparent following secondary challenge
4. Evolution of the T cell repertoire during primary, memory, and recall responses to viral infection
5. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169
6. Immunoproteasomes shape immunodominance hierarchies of antiviral CD8+ T cells at the levels of T cell repertoire and presentation of viral antigens
7. Prediction of transmembrane alpha-helices in procaryotic membrane proteins: The dense alignment surface method
8. Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase
9. Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope
10. Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands
11. Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast
12. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
13. + T lymphocytes in healthy seropositive donors
14. DNA immunization confers protection against murine cytomegalovirus infection
15. In vivo replication of recombinant murine cytomegalovirus driven by the paralogous major immediate-early promoter-enhancer of human cytomegalovirus
16. Immune evasion by cytomegalovirus - Survival strategies of a highly adapted opportunist
17. 10 memory-effector cell pool during latent murine cytomegalovirus infection of the lungs
18. Control of murine cytomegalovirus in the lungs: Relative but not absolute immunodominance of the immediate-early 1 nonapeptide during the antiviral cytolytic T-lymphocyte response in pulmonary infiltrates
19. Experimental preemptive immunotherapy of murine cytomegalovirus disease with CD8 T-cell lines specific for ppM83 and pM84, the two homologs of human cytomegalovirus tegument protein ppUL83 (pp65)
20. The putative natural killer decoy early gene m04 (gp34) of murine cytomegalovirus encodes an antigenic peptide recognized by protective antiviral CD8 T cells
21. d-restricted antigenic peptide encoded by murine cytomegalovirus early gene M84
22. A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20S proteasome
23. A kinetic model of vertebrate 20S proteasome accounting for the generation of major proteolytic fragments from oligomeric peptide substrates
24. T-cell epitope mapping by flow cytometry
25. + T-cell response to human cytomegalovirus: The 72-kilodalton major immediate-early protein revisited
26. A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface
27. Antigen processing by the proteasome
28. d epitope is generated and translocated into the endoplasmic reticulum as an I I-mer precursor peptide
29. The role of T-lymphocyte subsets in the control of cytomegalovirus infection
30. Identification of HLA-B27-restricted peptides from the Chlamydia trachomalis proteome with possible relevance to HLA-B27-associated diseases
31. Focal transcriptional activity of murine cytomegalovirus during latency in the lungs
32. Latency versus persistence or intermittent recurrences: Evidence for a latent state of murine cytomegalovirus in the lungs
33. Identification of a monoclonal antibody specific for a murine T3 polypeptide
34. Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection in mice
35. Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses
36. In vivo replication, latency, and immunogenicity of murine cytomegalovirus mutants with deletions in the M83 and M84 genes, the putative homologs of human cytomegalovirus pp65 (UL83)
37. Suppression of murine cytomegalovirus (MCMV) replication with a DNA vaccine encoding MCMV M84 (a homolog of human cytomegalovirus pp65)
38. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
39. Murine model of interstitial cytomegalovirus pneumonia in syngeneic bone marrow transplantation: Persistence of protective pulmonary CD8-T-cell infiltrates after clearance of acute infection
40. Reconstitution of CD8 T cells is essential for the prevention of multiple-organ cytomegalovirus histopathology after bone marrow transplantation
41. Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection
42. Analysis of the complete DNA sequence of murine cytomegalovirus
43. The immunogenicity of human and murine cytomegaloviruses
44. The conditions of primary infection define the load of latent viral genome in organs and the risk of recurrent cytomegalovirus disease
45. Adoptive immunotherapy of murine cytomegalovirus adrenalitis in the immunocompromised host: CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors
46. Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection
47. In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infection
48. A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes
49. Interstitial murine cytomegalovirus pneumonia after irradiation: Characterization of cells that limit viral replication during established infection of the lungs
50. Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: Pattern of recovery and correlation with cytomegalovirus infection and disease
51. + T-cell populations with differing cytolytic activities
52. Topology prediction for helical transmembrane proteins at 86% accuracy
53. Inactivation of a defined active site in the mouse 20S proteasome complex enhances major histocompatibility complex class I antigen presentation of a murine cytomegalovirus protein
54. The proteasome regulator PA28 alpha/beta can enhance antigen presentation without affecting 20S proteasome subunit composition
55. Attrition of T cell memory: Selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
56. Conserved T cell repertoire in primary and memory CD8 T cell responses to an acute viral infection
57. Preemptive CD8 T-cell immunotherapy of acute cytomegalovirus infection prevents lethal disease, limits the burden of latent viral genomes, and reduces the risk of virus recurrence
58. PA28α/β double and PA28β single transfectant mouse B8 cell lines reveal enhanced presentation of a mouse cytomegalovirus (MCMV) pp89 MHC class I epitope
59. Detection of individual mouse splenic T cells producing IFN-γ and IL-5 using the enzyme-linked immunospot (ELISPOT) assay
60. Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products
61. Induction of bystander T cell proliferation by viruses and type I interferon in vivo
62. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor
63. The memory cytotoxic T-lymphocyte (CTL) response to human cytomegalovirus infection contains individual peptide-specific CTL clones that have undergone extensive expansion in vivo
64. Cytomegaloviruses use multiple mechanisms to elude the host immune response
65. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: Frequency, specificity, and T-cell receptor usage of pp65-specific CTL
66. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses
67. Cut and trim: Generating MHC class I peptide ligands