Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products

Journal of Experimental Medicine

Volumn 194, Issue 1, 2001, Pages 1-12

  Toes, R E M ^b   Nussbaum, A K ^a   Degermann, S ^d   Schirle, M ^a   Emmerich, N P N ^a   Kraft, M ^a   Laplace, C ^d   Zwinderman, A ^b   Dick, T P ^c   Muller J ^a   Schonfisch B ^a   Schmid, C ^a   Fehling, H J ^e   Stevanovic, S ^a   Rammensee, H G ^a   Schild, H ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^e UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Constitutive proteasomes; CTL epitope; Immunoproteasomes; Peptide repertoire; Tolerance

Indexed keywords

AMINO ACID; ENOLASE; EPITOPE; PEPTIDE FRAGMENT; PROTEASOME;

AMINO ACID ANALYSIS; ANIMAL CELL; ARTICLE; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN PROCESSING; T LYMPHOCYTE ACTIVATION; VACCINE PRODUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; EPITOPES; FEMALE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MICE; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PHOSPHOPYRUVATE HYDRATASE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; SKIN TRANSPLANTATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035796461     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.1.1     Document Type: Article

References (38)

1. Peptides naturally presented by MHC class I molecules
2. Degradation of cell proteins and the generation of MHC class I-presented peptides
3. Mechanisms of MHC class I-restricted antigen processing
4. Structure and functions of the 20S and 26S proteasomes
5. The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processing
6. Contribution of proteasomal β-subunits to the cleavage of peptide substrates analyzed with yeast mutants
7. Structure of 20S proteasome from yeast at 2.4 Angstrom resolution
8. Interferon γ stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes
9. The interferon-γ-inducible 11 S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20 S proteasome in vitro
10. γ-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes
11. Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity
12. Altered properties of the branched chain amino acid-preferring activity contribute to increased cleavages after branched chain residues by the "immunoproteasome"
13. MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells
14. Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes
15. Differential influence on cytotoxic t lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28
16. Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 α/β, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope
17. Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7
18. Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide
19. Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome-dependent and -independent proteolytic activities
20. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells
21. Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1
22. Quasi-likelihood functions, generalized linear models, and the Gauss-Newton method
23. MHC class I expression in mice lacking the proteasome subunit LMP-7
24. Influences of transporter associated with antigen processing (TAP) on the repertoire of peptides associated with the endoplasmic reticulum-resident stress protein gp96
25. A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway
26. Mutations that impair a posttranscriptional step in expression of HLA-A and -B antigens
27. Methods and algorithms for statistical analysis of protein sequences
28. Immunoproteasome assembly: Cooperative incorporation of interferon γ-inducible subunits
29. Minor histocompatibility antigens
30. Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein
31. Contribution of proline residue for efficient production of MHC class 1 ligands by proteasomes
32. An algorithm for the prediction of proteasomal cleavages
33. Amino acid identity and/or position determines the proteasomal cleavage of the HLA-A*0201-restricted peptide tumor antigen MAGE-3271-279
34. The function of the proteasome system in MHC class I antigen processing
35. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
36. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes
37. The induction of tolerance by dendritic cells that have captured apoptotic cells
38. + T cells