The murine cytomegalovirus pp89 immunodominant H-2Ld epitope is generated and translocated into the endoplasmic reticulum as an 11-mer precursor peptide

Journal of Immunology

Volumn 167, Issue 3, 2001, Pages 1515-1521

  Knuehl, C ^a   Spee, P ^a   Ruppert, T ^a   Kuckelkorn, U ^a   Henklein, P ^a   Neefjes, J ^a   Kloetzel, P M ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME; PROTEIN PA28; PROTEIN PRECURSOR; PROTEIN TAP; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN PP89;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; ENDOPLASMIC RETICULUM; INTRACELLULAR TRANSPORT; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

EID: 0035424145     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.3.1515     Document Type: Article

References (42)

1. Proteasomes and antigen processing
2. Structure of 20S proteasome from yeast at 2.4 Å resolution
3. Subunit arrangement in the human 20S proteasome
4. Purification of an 11S regulator of the multicatalytic protease
5. Identification, purification, and characterization of a protein activator (PA28) of the 20S proteasome (macropain)
6. Molecular cloning and expression of a γ-interferon-inducible activator of the multicatalytic protease
7. A role for the proteasome regulator PA28α in antigen presentation
8. Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominam MHC ligands
9. Impaired immunoproteasome assembly and immune responses in PA28(-/-) mice
10. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter
11. Peptide size selection by the major histocompatibility complex-encoded peptide transporter
12. Human transporters associated with antigen processing possess a promiscuous peptide-binding site
13. Interferon-γ can stimulate post-proteasomal trimming of the N-terminus of an antigenic peptide by inducing leucine aminopeptidase
14. Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences
15. A single residue exchange within a vital CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation
16. The cleavage preference of the proteasome governs the yield of antigenic peptides
17. Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation
18. Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer
19. Kinetic evidence for facilitation of peptide channelling by the proteasome activator PA28
20. TAP-translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin
21. The rational design of TAP inhibitors using peptide substrate modifications and peptidomimetics
22. Cytotoxic T lymphocyte epitopes of HIV-1 nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes
23. Double-cleavage production of the CTL epitope by proteasomes and PA28: Role of the flanking region
24. Interferon-γ stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes
25. Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of inununoproteasomes
26. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules
27. Incorporation of major histocompatibility complex-encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-γ
28. Class I-restricted presentation occurs without internalization or processing of exogenous antigenic peptides
29. Sequences that flank subdominant and cryptic epitopes influence the proteolytic generation of MHC class I-presented peptides
30. Selectivity of MHC-encoded peptide transporters from human, mouse and rat
31. Transporter associated with antigen processing
32. Analysis of the tine specificity of rat, mouse and human TAP peptide transporters
33. The peptide-binding motif for the human transporter associated with antigen processing
34. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
35. Endogenous peptides of a soluble major histocompatibility complex class I molecule, H-2Lds: Sequence motif, quantitative binding, and molecular modeling of the complex
36. Consensus motifs and peptide ligands of MHC class I molecules
37. Redistribution of critical major histocompatibility complex and T cell receptor-binding functions of residues in an antigenic sequence after biterminal substitution
38. Cellular peptide composition governed by major histocompatibility complex class I molecules
39. Evidence for successive peptide binding and quality control stages during MHC class I assembly
40. Trimming of antigenic peptides in an early secretory compartment
41. Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum
42. Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC I-dependent peptide trimming in the ER