Cytomegaloviruses use multiple mechanisms to elude the host immune response

Immunology Letters

Volumn 57, Issue 1-3, 1997, Pages 213-216

  Wiertz, Emmanuel ^a   Hill, Ann ^b   Tortorella, Dominic ^c   Ploegh, Hidde ^c  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cytomegalovirus; Immune system; MHC class I

Indexed keywords

GLYCOPROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANTIGEN PRESENTATION; CONFERENCE PAPER; CYTOMEGALOVIRUS; ENDOPLASMIC RETICULUM; HUMAN; IMMEDIATE EARLY GENE; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VIRUS INFECTION;

ANIMALS; CYTOMEGALOVIRUS; GLYCOPROTEINS; HUMANS; VIRAL PROTEINS;

EID: 0030843814     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2478(97)00073-4     Document Type: Conference Paper

References (24)

1. T.R. Jones, L.K. Hanson, L. Sun, J.S. Slater, R.M. Stenberg, A.E. Campbell, Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains, J. Virol. 69 (1995) 4830-4841.
2. E.J.H.J. Wiertz, T.R. Jones, L. Sun, M. Bogyo, H.J. Geuze, H.L. Ploegh, The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the ER to the cytosol, Cell 84 (1996) 769-779.
3. E.J.H.J. Wiertz, D. Tortorella, M. Bogyo, J. Yu, W. Mothes, T.R. Jones, T.A. Rapoport, H.L. Ploegh, Secol-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature 384 (1996) 432-438.
4. E.A. Hughes, C. Hammond, P. Cresswell, Misfolded major histocompatibility complex class 1 heavy chains are translocated into the cytoplasm and degraded by the proteasome, Proc. Natl. Acad. Sci. USA 94 (1997) 1896-1901.
5. J.S. Bonifacino, Reversal of fortune for nascent proteins, Nature 384 (1996) 405-406.
6. K. Ahn, A. Angulo, P. Ghazal, P.A. Peterson, Y. Yang, K. Früh, Human cytomegalovirus inhibits antigen presentation by a sequential multistep process, Proc. Natl. Acad. Sci. USA 93 (1996) 10990-10995.
7. T.R. Jones, E.J.H.J. Wiertz, L. Sun, K.N. Fish, J.A. Nelson, H.L. Ploegh, Human cytomegalovirus US3 impairs transport and maturation of MHC Class I heavy chains, Proc. Natl. Acad. Sci. USA 93 (1996) 11327-11333.
8. M. Andersson, S. Paabo, T. Nilsson, P.A. Peterson, Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance, Cell 43 (1985) 215-222.
9. H.-G. Burgert, S. Kvist, An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens, Cell 41 (1985) 987-997.
10. R. Thale, U. Szepan, H. Hengel, G. Geginat, P. Lucin, U.H. Koszinowski, Identification of the mouse cytomegalovirus genomic region affecting major histocompatibility complex class I molecule transport, J. Virol. 69 (1995) 6098-6105.
11. M. del Val, H. Hengel, H. Hacker, U. Hartlaub, T. Ruppert, P. Lucin, U. Koszinowski, Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment, J. Exp. Med. 176 (1992) 729-738.
12. A. Hill, P. Jugovic, I. York, G. Russ, J. Bennink, J. Yewdell, H.L. Ploegh, D. Johnson, Herpes simplex virus turns off the TAP to evade host immunity, Nature 375 (1995) 411-415.
13. K. Früh, K. Ahn, H. Djaballah, P. Sempé, P.M. van Endert, R. Tampé, P.A. Peterson, Y.A. Yang, A viral inhibitor of peptide transporters for antigen presentation. Nature 375 (1995) 415-418.
14. K. Ahn, A. Gruhler, B. Galocha, T.R. Jones, E.J.H.J. Wiertz, H.L. Ploegh, P.A. Peterson, Y. Yang, K. Früh, The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity, in press.
15. H. Hengel, J.O. Koopman, T. Flohr, W. Muranyi, E. Goulmy, G.J. Hämmerling, U.H. Koszinowski, F. Momburg, A viral ER resident glycoprotein inactivates the MHC encoded peptide transporter, Immunity, in press.
16. H.T. Reyburn, O. Mandelboim, M. Valés-Gómez, D.M. Davis, L. Pazmany, J.L. Strominger, The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells, Nature 386 (1997) 514-517.
17. H.E. Farrell, H. Vally, D.M. Lynch, P. Fleming, G.R. Shellam, A.A. Scalzo, N.J. Davis-Poynter, Inhibition of natural killer cells by a cytomegalovirus MHC class I homologue in vivo. Nature 386 (1997) 510-514.
18. M.J. Gilbert, S.R. Riddell, B. Plachter, P.D. Greenberg, Cytomegalovirus selectively blocks antigen processing of its immediate-early gene product. Nature 384 (1996) 720-722.
19. A.E. Campbell, J.S. Slater, V.J. Cavanaugh, R.M. Stenberg, An early event in murine cytomegalovirus replication inhibits presentation of cellular antigens to cytotoxic T-lymphocytes, J. Virol. 66 (1992) 3011-3017.
20. M. Del Val, K. Munch, M.J. Reddehase, U.H. Koszinowski, Presentation of CMV early immediate early antigen to cytolytic T-lymphocytes is selectively prevented by viral genes expressed in the early phase, Cell 58 (1989) 305-315.
21. A.A. Scalzo, P.A. Lyons, N.A. Fitzgerald, C.A. Forbes, W.M. Yokoyama, G.R. Shellam, Genetic mapping of Cmv1 in the region of mouse chromosome 6 encoding the NK gene complex-associated loci Ly49 and musNKR-P1, Genomics 27 (1995) 435-441.
22. M.F. Kleijnen, J.B. Huppa, P. Lucin, S. Mukherjee, H. Farrel, A.E. Campbell, U.H. Koszinowski, A.B. Hill, H.L. Ploegh, A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface, EMBO J. 16 (1997) 685-694.
23. R. Machold, E.J.H.J. Wiertz, T.R. Jones, H.L. Ploegh, The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine MHC class I heavy chains, J. Exp. Med. 185 (1997) 363-366.
24. H. Ziegler, R. Thäle, P. Lucin, W. Muranyi, T. Flohr, H. Hengel, H. Farrell, W. Rawlinson, U.H. Koszinowski, A mouse cytomegalovirus glycoprotein retains MHC class I complexes in the ERGIC/cis-Golgi compartments, Immunity 6 (1997) 57-66.