Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection of mice

Journal of Experimental Medicine

Volumn 188, Issue 11, 1998, Pages 1993-2005

  Lin, Meei Yun ^a   Welsh, Raymond M ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Lymphocytic choriomeningitis virus; Memory; Mice; Spectratype; T cell receptor

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MOUSE; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; VIRUS MENINGITIS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; VARIATION (GENETICS);

EID: 0000066982     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.11.1993     Document Type: Article

References (33)

1. Welsh, R.M., M.Y. Lin, B.L. Lohman, S.M. Varga, C.C. Zarozinski, and L.K. Selin. 1997. αβ and γδ T cell networks and their roles in natural resistance to viral infections. Immunol. Rev. 159:79-93.
2. Kalams, S.A., R.P. Johnson, M.J. Dynan, K.E. Hartman, T. Harrer, E. Harrer, A.K. Trocha, W.A. Blattner, S.P. Buchbinder, and B.D. Walker. 1996. T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant. J. Exp. Med. 183:1669-1679.
3. Steven, N.M., A.M. Leese, N.E. Annels, S.P. Lee, and A.B. Rickinson. 1996. Epitope focusing in the primary cytotoxic T cell response to Epstein-Barr virus and its relationship to T cell memory. J. Exp. Med. 184:1801-1813.
4. Yanagi, Y., R. Maekawa, T. Cook, O. Kanagawa, and M.B.A. Oldstone. 1990. Restricted V-segment usage in T-cell receptors from cytotoxic T lymphocytes specific for a major epitope of lymphocytic choriomeningitis virus. J. Virol. 64:5919-5926.
5. Okamoto, Y., S.J. Gagnon, I. Kurane, A.M. Leporati, and F.A. Ennis. 1994. Preferential usage of T-cell receptor Vβ 17 by dengue virus-specific human T lymphocytes in a donor with immunity to dengue virus type 4. J. Virol. 68:7614-7619.
6. Ahmed, R., A. Salmi, L.D. Butler, J.M. Chiller, and M.B.A. Oldstone. 1984. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. J. Exp. Med. 160:521-540.
7. Moskophidis, D., F. Lechner, H. Pircher, and R.M. Zinkernagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature. 362:758-761.
8. Matloubian, M., S.R. Kolhekar, T. Somasundaram, and R. Ahmed. 1993. Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus. J. Virol. 67:7340-7349.
9. Selin, L.K., K. Vergilis, and R.M. Welsh. 1996. Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections. J. Exp. Med. 183:2489-2499.
10. Razvi, E.S., and R.M. Welsh. 1993. Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency. J. Virol. 67:5754-5765.
11. Razvi, E.S., Z. Jiang, B.A. Woda, and R.M. Welsh. 1995. Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice. Am. J. Pathol. 147:79-91.
12. Lau, L.L., B.D. Jamieson, T. Somasundaram, and R. Ahmed. 1994. Cytotoxic T-cell memory without antigen. Nature. 369:648-652.
13. Murali-Krishna, K., J.D. Altman, M. Suresh, D.J.D. Sourdive, A.J. Zajac, J.D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity. 8:177-187.
14. Zarozinski, C.C., and R.M. Welsh. 1997. Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response. J. Exp. Med. 185:1629-1639.
15. Pannetier, C., J. Evan, and P. Kourilsky. 1995. T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol. Today. 16:176-181.
16. Bjorkman, P.J. 1997. MHC restriction in three dimensions: a view of T cell receptor/ligand interaction. Cell. 89:167-170.
17. Welsh, R.M., P.W. Lampert, P.A. Burner, and M.B.A. Oldstone. 1976. Antibody-complement interactions with purified lymphocytic choriomeningitis virus. Virology. 73:59-71.
18. Planz, O., P. Seiler, H. Hengartner, and R.M. Zinkernagel. 1996. Specific cytotoxic T cells eliminate cells producing neutralizing antibodies. Nature. 382:726-729.
19. Nahill, S.R., and R.M. Welsh. 1993. High frequency of cross-reactive cytotoxic T lymphocytes elicited during the virus-induced polyclonal cytotoxic T lymphocyte response. J. Exp. Med. 177:317-327.
20. Selin, L.K., and R.M. Welsh. 1997. Cytolytically active memory CTL present in lymphocytic choriomeningitis virus-immune mice after clearance of virus infection. J. Immunol. 158:5366-5373.
21. Welsh, R.M. 1978. Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction. J. Exp. Med. 148:163-181.
22. Pannetier, C., M. Cochet, S. Darche, A. Casrouge, M. Zöller, and P. Kourilsky. 1993. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor β chains vary as a function of the recombined germ-line segments. Proc. Natl. Acad. Sci. USA. 90:4319-4323.
23. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
24. Blüthmann, H., P. Kisielow, Y. Uematsu, M. Malissen, P. Krimpenfort, A. Berns, H. von Boehmer, and M. Steinmetz. 1988. T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α- and β-genes. Nature. 334:156-159.
25. + cytotoxic T cell activation and memory in virus infection. J. Immunol. 149:1326-1333.
26. Lohman, B.L., and R.M. Welsh. 1998. Apoptotic regulation of T cells and absence of immune deficiency in virus-infected IFN-γ receptor knock-out mice. J. Virol. 72:7815-7821.
27. + memory T cells in virus-infected hosts. J. Exp. Med. 183:1367-1375.
28. de Campos-Lima, P.O., V. Levitsky, M.P. Imreh, R. Gavioli, and M.G. Masucci. 1997. Epitope-dependent selection of highly restricted or diverse T cell receptor repertoires in response to persistent infection by Epstein-Barr virus. J. Exp. Med. 186:83-89.
29. Selin, L.K., S.R. Nahill, and R.M. Welsh. 1994. Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J. Exp. Med. 179:1933-1943.
30. Bachmann, M.F., D.E. Speiser, and P.S. Ohashi. 1997. Functional maturation of an antiviral cytotoxic T-cell response. J. Virol. 71:5764-5768.
31. Maryanski, J.L., C.V. Jongeneel, P. Bucher, J.L. Casanova, and P.R. Walker. 1996. Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones. Immunity. 4:47-55.
32. Guberski, D.L., V.A. Thomas, W.R. Shek, A.A. Like, E.S. Handler, A.A. Rossini, J.E. Wallace, and R.M. Welsh. 1991. Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/W or rats. Science. 254:1010-1013.
33. Chou, H.S., S.J. Anderson, M.C. Louie, S.A. Godambe, M.R. Pozzi, M.A. Behlke, K. Huppi, and D.Y. Loh. 1987. Tandem linkage and unusual RNA splicing of the T-cell receptor β-chain variable-region genes. Proc. Natl. Acad. Sci. USA. 84:1992-1996.