Reconstitution of CD8 T cells is essential for the prevention of multiple-organ cytomegalovirus histopathology after bone marrow transplantation

Journal of General Virology

Volumn 79, Issue 9, 1998, Pages 2099-2104

  Podlech, Jürgen ^a   Holtappels, Rafaela ^a   Wirtz, Nikolaus ^a   Steffens, Hans Peter ^a   Reddehase, Matthias J ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ARTICLE; BONE MARROW TRANSPLANTATION; CYTOMEGALOVIRUS INFECTION; HISTOPATHOLOGY; INFECTION PREVENTION; PRIORITY JOURNAL; T LYMPHOCYTE;

CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; DNA VIRUSES; MURINAE;

EID: 0031715277     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-79-9-2099     Document Type: Article

References (29)

1. Balthesen, M., Messerle, M. & Reddehase, M. J. (1993). Lungs are a major organ site of cytomegalovirus latency and recurrence. Journal of Virology 67, 5360-5366.
2. Cobbold, S. P., Jayasuriya, A., Nash, A., Prospero, T. D. & Waldmann, H. (1984). Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312, 548-550.
3. Dobonici, M., Podlech, J., Steffens, H.-P., Maiberger, S. & Reddehase, M. J. (1998). Evidence against a key role for transforming growth factor-β1 in cytomegalovirus-induced bone marrow aplasia. Journal of General Virology 79, 867-876.
4. Ebeling, A., Keil, G. M., Knust, E. & Koszinowski, U. H. (1983). Molecular cloning and physical mapping of murine cytomegalovirus DNA. Journal of Virology 47, 421-433.
5. Einsele, H., Hebart, H., Bokemeyer, C., Kanz, L., Jahn, G. & Müller, C. A. (1998). Cytomegalovirus infection following hematopoietic stem cell transplantation. Monographs in Virology 21, 106-118.
6. Holt, P. G., Degebrodt, A., Venaille, T., O'Leary, C., Krska, K., Flexman, J., Farrell, H., Shellam, G., Young, P., Penhale, J., Robertson, T. & Papadimitriou, J. M. (1985). Preparation of interstitial lung cells by enzymatic digestion of tissue slices: preliminary characterization by morphology and performance in functional assays. Immunology 54, 139-147.
7. + T lymphocytes. Journal of Experimental Medicine 169, 1199-1212.
8. + T lymphocytes. Journal of Virology 64, 5457-5464.
9. Jonjić, S., Pavić, I., Polić, B., Crnković, I., Lučin, P. & Koszinowski, U. H. (1994). Antibodies are not essential for the resolution of primary cytomegalovirus infection but limit dissemination of recurrent virus. Journal of Experimental Medicine 179, 1713-1717.
10. Kesari, S., Lasner, T. M., Balsara, K. R., Randazzo, B. P., Lee, V. M.-Y., Trojanowski, J. Q. & Fraser, N. W. (1998). A neuroattenuated ICP34.5-deficient herpes simplex virus type 1 replicates in ependymal cells of the murine central nervous system. Journal of General Virology 79, 525-536.
11. Koszinowski, U. H., Reddehase, M. J. & Jonjić, S. (1993). The role of T-lymphocyte subsets in the control of cytomegalovirus infection. In Viruses and the Cellular Immune Response, pp. 429-445. Edited by D. B. Thomas. New York: Marcel Dekker.
12. Lathbury, L. J., Allan, J. E., Shellam, G. R. & Scalzo, A. A. (1996). Effect of host genotype in determining the relative roles of natural killer cells and T cells in mediating protection against murine cytomegalovirus infection. Journal of General Virology 77, 2605-2613.
13. Lučin, P., Jonjić, S., Messerle, M., Polić, B., Hengel, H. & Koszinowski, U. H. (1994). Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor. Journal of General Virology 75, 101-110.
14. Mayer, A., Podlech, J., Kurz, S., Steffens, H.-P., Maiberger, S., Thalmeier, K., Angele, P., Dreher, L. & Reddehase, M. J. (1997). Bone marrow failure by cytomegalovirus is associated with an in vivo deficiency in the expression of essential stromal hemopoietin genes. Journal of Virology 71, 4589-4598.
15. Mutter, W., Reddehase, M. J., Busch, F. W., Bühring, H.-J. & Koszinowski, U. H. (1988). Failure in generating hematopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host. The Journal of Experimental Medicine 167, 1645-1658.
16. Pavić, I., Polić, B., Crnković, I., Lučin, P., Jonjić, S. & Koszinowski, U. H. (1993). Participation of endogenous tumour necrosis factor α in host resistance to cytomegalovirus infection. Journal of General Virology 74, 2215-2223.
17. Polić, B., Jonjić, S., Pavić, I., Crnković, I., Zorica, I., Hengel, H., Lučin, P. & Koszinowski, U. H. (1996). Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo. Journal of General Virology 77, 217-225.
18. Rawlinson, W. D., Farrell, H. E. & Barrell, B. G. (1996). Analysis of the complete DNA sequence of murine cytomegalovirus. Journal of Virology 70, 8833-8849.
19. Reddehase, M. J., Weiland, F., Münch, K., Jonjić, S., Lüske, A. & Koszinowski, U. H. (1985). Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs. Journal of Virology 55, 264-273.
20. Reddehase, M. J., Mutter, W. & Koszinowski, U. H. (1987a). In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infection. Journal of Experimental Medicine 165, 650-656.
21. Reddehase, M. J., Mutter, W., Münch, K., Bühring, H.-J. & Koszinowski, U. H. (1987b). CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity. Journal of Virology 61, 3102-3108.
22. Reddehase, M. J., Jonjić, S., Weiland, F., Mutter, W. & Koszinowski, U. H. (1988). Adoptive immunotherapy of murine cytomegalovirus adrenalitis in the immunocompromised host: CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors. Journal of Virology 62, 1061-1065.
23. Reusser, P., Riddell, S. R., Meyers, J. D. & Greenberg, P. D. (1991). Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease. Blood 78, 1373-1380.
24. Riddell, S. R., Watanabe, K. S., Goodrich, J. M., Li, C. R., Agha, M. E. & Greenberg, P. D. (1992). Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257, 238-241.
25. Salazar-Mather, T. P., Orange, S. J. & Biron, C. A. (1998). Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1α (MIP-1α)-dependent pathways. Journal of Experimental Medicine 187, 1-14.
26. Steffens, H.-P., Kurz, S., Holtappels, R. & Reddehase, M. J. (1998a). Preemptive CD8 T-cell immunotherapy of acute cytomegalovirus infection prevents lethal disease, limits the burden of latent viral genomes, and reduces the risk of virus recurrence. Journal of Virology 72, 1797-1804.
27. Steffens, H.-P., Podlech, J., Kurz, S., Angele, P., Dreis, D. & Reddehase, M. J. (1998b). Cytomegalovirus inhibits the engraftment of donor bone marrow cells by downregulation of hemopoietin gene expression in recipient stroma. Journal of Virology 72, 5006-5015.
28. Walter, E. A., Greenberg, P. D., Gilbert, M. J., Finch, R. J., Watanabe, K. S., Thomas, E. D. & Riddell, S. R. (1995). Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. New England Journal of Medicine 333, 1038-1044.
29. Winston, D. J., Ho, W. G. & Champlin, R. E. (1990). Cytomegalovirus infections after bone marrow transplantation. Reviews of Infectious Diseases 12, S776-S792.