Uncoupling proteins: Their roles in adaptive thermogenesis and substrate metabolism reconsidered

British Journal of Nutrition

Volumn 86, Issue 2, 2001, Pages 123-139

  Dulloo, A G ^a   Samec, S ^a  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

Cachexia; Energy expenditure; Fat oxidation; Obesity; Starvation; Uncoupling proteins 2 and 3

Indexed keywords

AMINO ACID; CARRIER PROTEIN; DNA; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ADAPTATION; ADIPOSE TISSUE; BODY COMPOSITION; BODY WEIGHT; CACHEXIA; DIET RESTRICTION; DNA MODIFICATION; ENERGY BALANCE; ENERGY EXPENDITURE; ENZYME METABOLISM; FEEDING BEHAVIOR; FOOD INTAKE; GENE MAPPING; GENETIC ANALYSIS; GENETIC SCREENING; GENOME; HUMAN; LIPID OXIDATION; LIPID TRANSPORT; MEDICAL LITERATURE; METABOLIC RATE; MITOCHONDRION; MOLECULAR CLONING; MOLECULAR DYNAMICS; OBESITY; OXIDATIVE STRESS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SKELETAL MUSCLE; THERMOGENESIS;

EID: 0034891713     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/bjn2001412     Document Type: Review

References (105)

1. Influence of β-adrenergic blockade on glucose-induced thermogenesis in man
2. Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs
3. Enzymatic and metabolic adaptations in the gastrocnemius, plantaris and soleus muscles of hypocaloric rats
4. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
5. Disruption of the uncoupling-2 gene in mice reveals a role in immunity and reactive oxygen species production
6. Sympathoadrenal system and metabolism
7. Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expenditure and substrate oxidation
8. The contribution of hepatic metabolism to diet-induced thermogenesis
9. Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes
10. Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
11. Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism
12. The significance and mechanism of mitochondrial proton conductance
13. Uncoupling protein-3 gene expression in skeletal muscle during development is regulated by nutritional factors that alter circulating non-esterified fatty acids
14. UCP2 and UCP3 rise in starved rat skeletal muscle but not mitochondrial proton conductance is unchanged
15. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
16. In vivo effects of uncoupling protein 3 gene disruption on mitochondrial metabolism
17. Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes
18. Differential regulation of uncoupling protein-1, -2 and -3 gene expression by sympathetic innervation in brown adipose tissue of thermoneutral or cold-exposed rats
19. Mitochondrial uncoupling protein 2 (UCP2) in the nonhuman primate brain and pituitary
20. UCP2 and UCP3: Candidate genes for thermogenesis or lipid handling
21. Adaptive changes in energy expenditure during refeeding following low calorie intake: Evidence for a specific metabolic component favoring fat storage
22. Influence of dietary composition on energy expenditure during recovery of body weight in the rat: Implications for catch-up growth and obesity relapse
23. Adaptive reduction in basal metabolic rate in response to food deprivation in humans: A role for feedback signals from fat stores
24. Low-protein overfeeding: A tool to unmask susceptibility to obesity in humans
25. An adipose-specific control of thermogenesis in body weight regulation
26. Energy balance following sympathetic denervation of brown adipose tissue
27. Obesity: A disorder of the sympathetic nervous system
28. Uncoupling proteins: Do they have a role in weight regulation?
29. Dissociation of enhanced efficiency of fat deposition during weight recovery from sympathetic control of thermogenesis
30. Autoregulation of body composition during weight recovery in humans: The Minnesota Experiment revisited
31. Mice lacking mitochondrial uncoupling protein are cold sensitive but not obese
32. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinaemia
33. On the mechanism of fatty acid-induced proton transport by mitochondrial protein
34. Brown fat: An energy dissipating tissue
35. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β-adrenergic agonists, and leptin
36. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
37. Mitochondrial efficiency: Lessons learned from transgenic mice
38. Exercise attenuates the fasting-induced transcriptional activation of metabolic genes in skeletal muscle
39. Brown adipose tissue thermogenesis and obesity
40. Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: An hypothesis
41. Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects
42. Effect of long-term high-fat feeding on energy balance and liver oxidative activity in rats
43. Humoral thermogenesis and its role in maintaining energy balance
44. Fatty acid cycling mechanism and mitochondrial uncoupling proteins
45. 31P NMR assessment of mitochondrial energy coupling in skeletal muscle of awake fed and fasted rats: Relationship with uncoupling protein 3 expression
46. Mitochondrial uncoupling proteins in energy expenditure
47. The sympathoadrenal system and regulation of thermogenesis
48. Mémoire sur la Chaleur
49. Brown adipose tissue in humans
50. Brown adipose tissue in patients with phaeochromocytoma
51. Changes in energy expenditure resulting from altered body weight
52. Role of non-exercise activity thermogenesis in resistance to fat gain in humans
53. Basal metabolic rate, fat-free-mass, and body cell mass during energy restriction
54. Starvation-induced changes in metabolic rate, blood flow, and regional energy expenditure in rats
55. Evidence for liver as the major site of the diet-induced thermogenesis of rats fed a cafeteria-diet
56. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
57. Thermogenic responses in brown fat cells are fully UCP1-dependent
58. Factors affecting energy expenditure
59. Gluttony 1. An experimental study of overeating low- or high-protein diets
60. Gluttony 2. Thermogenesis in overeating man
61. Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans
62. Increased mitochondrial proton leak in skeletal muscle mitochondria of UCP1-deficient mice
63. Fuel metabolism in muscles from UCP-3 knock-out mice
64. 3-adrenergic agonist
65. The uncoupling protein thermogenin and mitochondrial thermogenesis
66. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation
67. A history of the first uncoupling protein, UCP1
68. Effects of fatty acids, nucleotides and reactive oxygen species on durum wheat mitochondria
69. Regulation of GDP binding and uncoupling protein concentration in brown adipose tissue mitochondria
70. Uncoupling protein 2: In vivo distribution, induction upon oxidative stress and evidence for translational regulation
71. Genetic and physiological analysis of the role of uncoupling proteins in human energy homeostasis
72. An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds
73. Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver
74. Brain distribution of UCP2 mRNA: In situ hybridization histochemistry studies
75. The family of uncoupling proteins and its role in energy expenditure and body weight control
76. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
77. Contribution of mitochondrial proton leak to skeletal muscle respiratory and to standard metabolic rate
78. A role for brown adipose tissue in diet-induced thermogenesis
79. Role of UCP homologues in skeletal muscles and brown adipose tissue: Mediators of thermogenesis or regulators of lipids as fuel substrate?
80. Interorgan signaling between brown adipose tissue metabolism and skeletal muscle uncoupling protein homologs: Is there a role for circulating free fatty acids?
81. Post-starvation gene expression of skeletal muscle uncoupling protein 2 and uncoupling protein 3 in response to dietary fat levels and fatty acid composition. A link with insulin resistance
82. Further dissociations between skeletal muscle UCPs gene expressions and dietary regulation of thermogenesis
83. Downregulation of skeletal muscle UCP-3 gene expression during refeeding is prevented by cold exposure
84. Skeletal muscle heterogeneity in fasting-induced upregulation of genes encoding UCP2, UCP3 and key regulators of lipid oxidation
85. BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast
86. Fiber type dependent upregulation of human skeletal muscle UCP2 and UCP3 mRNA expression by high-fat diet
87. Overexpression of muscle uncoupling protein-2 in human obesity associated with reduced muscle lipid utilization
88. Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants
89. Uncoupling: New approaches to an old problem of bioenergetics
90. Gluttony and thermogenesis revisited
91. Molecular and genetic aspects of the UCPs: View from the chair
92. The hormone resistin links obesity to diabetes
93. Mitochondrial proton leak and the uncoupling protein 1 homologues
94. Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria
95. Energy expenditure and thermogenesis: Animal studies on brown adipose tissue
96. Effects of fatty acids on uncoupling protein-2 expression in the rat heart
97. Cloning and functional characterization of an uncoupling protein homolog in hummingbirds
98. An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
99. Energy metabolism in uncoupling protein 3 gene knockout mice
100. Elevated free fatty acids induce uncoupling protein 3 expression in muscle. A potential explanation for the effect of fasting
101. Development of beta 3-adrenoceptor agonists for the treatment of obesity and diabetes - An update
102. Energy metabolism after 2 yr of energy restriction: The Biosphere 2 experiment
103. Transgenic animals in integrative biology: Approaches and interpretations of outcome
104. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation