Chromatin structure and transcriptional regulation of the β-globin locus

Experimental Cell Research

Volumn 278, Issue 1, 2002, Pages 1-11

  Fu, Xiang Hui ^a   Liu, De Pei ^a   Liang, Chih Chuan ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

Chromatin; Histone acetylation; Intergenic transcription; Locus control region; SWI SNF; globin locus

Indexed keywords

BETA GLOBIN;

ACETYLATION; CHROMATIN STRUCTURE; EUKARYOTE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; REVIEW; TRANSCRIPTION REGULATION;

EUKARYOTA;

EID: 0036075653     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5555     Document Type: Review

References (113)

1. Histone acetylation beyond promoters: Long-range acetylation patterns in the chromatin world
2. Exploring the transcription-chromatin interface
3. Conservation of sequence and structure flanking the mouse and human beta-globin loci: The beta-globin genes are embedded within an array of odorant receptor genes
4. Hemoglobin switching
5. Expression of α- and β-globin genes occurs within different nuclear domains in haemopoietic cells
6. A developmentally stable chromatin structure in the human beta-globin gene cluster
7. The 'beta-like globin' gene domain in the human erythroid cells
8. Position-independent, high-level expression of the human beta-globin in transgenic mice
9. Looping, linking, and chromatin activity: New insights into β-globin locus regulation
10. Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region
11. The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus
12. The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells
13. Looping versus linking: Toward a model for long-distance gene activation
14. Locus control regions coming of age at a decade plus
15. Locus control regions and epigenetic chromatin modifiers
16. Beyond the locus control region: New light on β-globin locus regulation
17. In vivo formation of a human beta-globin locus control region core element requires binding sites for multiple factors including GATA-1, NF-E2, erythroid Kruppel-like factor, and Spl
18. Altered DNA-binding specificity mutants of EKLF and SP1 show that EKLF is an activator of the beta-globin locus control region in vivo
19. Activation of the beta globin locus by transcription factors and chromatin modifiers
20. Purification and properties of an ATP-dependent nucleosome remodeling factor
21. Chromatin remodeling at the PHO8 promoter requires a SWI-SNF and SAGA at a step subsequent to activation binding
22. SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro
23. Targeting a SWI/SNF-related chromatin remodeling complex to the beta-globin promoter in erythroid cells
24. Functional selectivity of recombinant mammalian SWI/SNF subunits
25. Distinct domains of erythroid kruppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoter
26. NF-E2 disrupts chromatin structure at human beta-globin locus control region hypersensitive site 2 in vitro
27. Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly
28. Understanding "active" chromatin: A historical perspective of chromatin remodeling
29. Chromatin-remodeling factor CHRAC contains the ATPases ISWI and topoisomerase II
30. The many faces of chromatin remodeling: Switching beyond transcription
31. Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4
32. Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription
33. Activation of the β-globin locus control region precedes commitment to the erythroid lineage
34. A dominant chromatin-opening activity in 5′ hypersensitive site 3 of the human β-globin locus control region
35. Individual LCR hypersensitive sites cooperate to generate an open chromatin domain spanning the human β-globin locus
36. Independent formation of DNase I hypersensitive sites in the murine β-globin locus
37. A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse β-globin locus
38. Targeted deletion of 5′ HS1 and 5′HS4 of the β-globin locus control region reveals additive activity of the DNase I hypersensitive sites
39. The hypersensitive sites of the endogenous β-globin locus control region act additively to affect the level but not the probability of transcription in individual cells
40. Simple math for the β-globin locus control region
41. Nuclear localization and histone acetylation: A pathway for chromatin opening and transcriptional activation of the human beta-globin locus
42. Nuclear compartmentalization and gene activity
43. The contribution of nuclear compartmentalization to gene regulation
44. Chromosome territories, nuclear architecture and gene regulation in mammalian cells
45. Positions of potential nuclear organization and gene expression
46. Global histone acetylation and deacetylation in yeast
47. Local or global
48. The murine β-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes
49. Acetylation of a specific promoter nucleosome accompanies activation of the epsilon-globin gene by beta-globin locus control region HS2
50. Distinct mechanisms control RNA polymerase II recruitment to a tissue-specific locus control region and a downstream promoter
51. Orchestrating response: A symphony of transcription factors for gene control
52. Enhanceosomes
53. Core promoters: Active contributors to combinatorial gene regulation
54. Cooperation between complexes that regulate chromatin structure and transcription
55. ATP-dependent chromatin-remodeling complexes
56. Transcriptional coactivator complexes
57. Promoter targeting and chromatin remodeling by the SWI/SNF complex
58. The language of covalent histone modifications
59. Chromatin alteration, transcription and replication: What's the opening line to story?
60. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity
61. Kruppel-like factors: Three fingers in many pies
62. Mammalian kruppel-like transcription factors: More than just a pretty finger
63. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene
64. Silencing of human fetal globin expression is impaired in the absence of the adult β-globin gene activation protein EKLF
65. Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF
66. Erythroid krupple-like factor is recruited to the CACCC box in the β-globin promoter but not to the CACCC box in the β-globin promoter: The role of the neighboring promoter elements
67. Context-dependent EKLF responsiveness defines the developmental specificity of the human β-globin gene in erythroid cells of YAC transgenic mice
68. Acetylation and modulation of erythroid kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases
69. Site-specific acetylation by p300 or CREB binding protein regulates erythroid Kruppel-like factor transcriptional activity via its interaction with the SWI-SNF complex
70. Unanticipated repression function linked to erythroid Kruppel-like factor
71. Novel trans-activation domain in erythroid kruppel-like factor (EKLF)
72. Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching
73. An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells
74. Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
75. DNA-dependent adenosine triphosphatase (helicaselike transcription factor) activates β-globin transcription in K562 cells
76. Chromatin goes global
77. Translating the histone code
78. Histone acetylation and an epigenetic code
79. An activity gel assay detects a single, catalytically active histone acetyltransferase subunit in Tetrahymena macronuclei
80. Histone acetyltransferases
81. Acetylation of histones and transcription-related factors
82. Histone acetylation and chromatin remodeling
83. Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain
84. Correlation between histone lysine methylation and developmental changes at the chicken β-globin locus
85. Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci
86. Expanded lysine acetylation specificity of Gen5 in native complexes
87. NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esalp and the ATM-related cofactor Tralp
88. Direct interaction of NF-E2 with hypersensitive site 2 of the beta-globin locus control region in living cells
89. Dissection of the enhancer activity of beta-globin 5′ DNase 1-hypersensitive site 2 in transgenic mice
90. Nuclear relocation of a transactivator subunit precedes target gene activation
91. Activation of βmajor globin gene transcription is associated with recruitment of NF-E2 to the β-globin LCR and gene promoter
92. Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation
93. Demonstration of globin messenger sequences in giant nuclear precursors of messenger RNA of avain erythroblasts
94. Globin RNA precursor molecules: Biosynthesis and processing in erythroid cells
95. Definition of the minimal requirements within the human β-globin genes for high level expression
96. Transcription of the hypersensitive site HS2 enhancer in erythroid cells
97. Intergenic transcription and transinduction of the human β-globin locus
98. Intergenic transcription in the human β-globin gene cluster
99. Transcription of HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhance relative to the gene
100. Intergenic transcription and developmental remodeling of chromatin subdomains in the human β-globin locus
101. Chromatin modification by DNA tracking
102. RNA polymerase II elongation through chromatin
103. A long terminal repeat of the human endogenous retrovirus ERV-9 is located in the 5′ boundary area of the human beta-globin locus control region
104. Transgenic analysis of a 110-kb beta-globin cluster-containing DNA fragments propagated as a bacterial artificial chromosome
105. Epigenetic aspects of X-chromosome dosage compensation
106. Intergenic transcription occurs throughout the human IL4/IL13 gene cluster
107. Epigenetic inheritance of active chromatin after removal of the main transactivator
108. Signal to chromatin through histone modifications
109. Code of silence
110. Transcription regulation by histone methylation: Interplay between different covalent modifications of the core histone tails
111. A unified theory of gene expression
112. CACCC and GATA-1 sequences make the constitutively expressed alpha-globin gene erythroid-responsive in mouse erythroleukemia cells
113. Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci