Transcription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene

Molecular and Cellular Biology

Volumn 17, Issue 7, 1997, Pages 3955-3965

  Kong, Suming ^a,c   Bohl, Daniel ^a,d   Li, Chunhua ^b   Tuan, Dorothy ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c Fuji ImmunoPharmaceuticals Corp   (United States)

^d WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLOBIN;

ANIMAL CELL; ARTICLE; ENHANCER REGION; ERYTHROID CELL; GENE LOCUS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENOME; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ANIMALIA; FELIS CATUS;

EID: 0030921097     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.7.3955     Document Type: Article

References (61)

1. Allan, M., W. G. Lanyon, and J. Paul. 1983. Multipie origins of transcription in the 4.5 kb upstream of the ε-globin gene. Cell 35:187-197.
2. Baralle, F., C. Shoulder, and N. Proudfoot. 1980. The primary structure of the human ε-globin gene. Cell 21:621-630.
3. Benz, E., M. J. Murnane, B. L. Tonkonow, B. W. Berman, E. M. Mazur, R. Cavallesco, T. Jenko, E. L. Snyder, B. G. Forget, and R. Hoffman. 1980. Embryonic-fetal erythroid characteristics of a human leukemic cell line. Proc. Natl. Acad. Sci. USA 77:3509-3513.
4. Bresnick, E., and G. Fesenfeld. 1993. Evidence that the transcription factor USF is a component of the human β-globin locus control region heteromeric protein complex. J. Biol. Chem. 268:18824-18833.
5. Caterina, J., D. Ciavatta, D. Donze, R. Behringer, and T. Townes. 1994. Multiple elements in human β-globin locus control region 5' HS2 are involved in enhancer activity and position-independent, transgene expression. Nucleic Acids Res. 22:1006-1011.
6. Cavallesco, R., and D. Tuan. 1997. Modulatory subdomains of the HS2 enhancer differentially regulate enhancer activity in erythroid cells at different developmental stages. Blood Cells Mol. Dis. 23:8-26.
7. 6a.Cavallesco, R., and D. Tuan. Unpublished observation.
8. Charnay, P., and T. Maniatis. 1983. Transcriptional regulation of globin gene expression in human erythroid cell line K562. Science 220:1281-1283
9. Curtin, P., M. Pirastu, Y. W. Kan, J. A. Gobert-Jones, A. D. Stephens, and H. Lehmann. 1985. A distant gene deletion affects β-globin gene function in an atypical γδβ-thalassemia. J. Clin. Invest. 76:1554-1558.
10. Curtin, P., D. Liu, W. Liu, J. C. Chang, and Y. W. Kan. 1989. Human β-giobin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site. Proc. Natl. Acad. Sci. USA 86:7082-7086.
11. Dean, A., T. Ley, K. Humphries, M. Fordis, and A. Schechter. 1983. Inducible transcription of five globin genes in K562 human leukemia cells. Proc. Natl. Acad. Sci. USA 80:5515-5519.
12. Driscoll, K., C. S. Dobkin, and B. P. Alter. 1989. δγβ-Thalassemia due to a de novo mutation deleting the 5' β-globin gene activation region hypersensitive sites. Proc. Natl. Acad. Sci. USA 86:7470-7474.
13. Ellis, J., D. Talbot, N. Dillion, and F. Groswld. 1993. A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human β-globin locus control region. EMBO J. 12:127-134.
14. Ellis, J., K. Tan-Un, A. Harper, D. Michalovich, N. Yannoutsos, S. Philipsen. and F. Grosveld. 1996. A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human β-globin locus control region. EMBO J. 15:562-568.
15. Enver, T., N. Raich, A. J. Ebens, T. Papayannopoulou, F. Costantini, and G. stamatoyannopoulos. 1990. Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice. Nature 344:309-313.
16. Fiering, S., E. Epner, K. Robinson, Y. Zhuang, A. Telling, M. Hu, D. Martin, T. Enver, T. Ley, and M. Groudine. 1995. Targeted deletion of 5 HS2 of the murine β-globin LCR reveals that it is not essential for proper regulation of the β-globin locus. Genes Dev. 9:2203-2213.
17. Fong, T. C., and B. Emerson. 1993. The erythroid protein cGATA-1 mediates distal enhancer activity through a specialized β-globin TATA box. Genes Dev. 6:521-532.
18. Forrester, W., S. Takegawa, T. Papayannopoulou, G. Stamatoyannopoulos, and M. Groudine. 1987. Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids. Nucleic Acids Res. 15:10159-10177.
19. Forrester, W. C., U. Novak, R. Gelinas, and M. Groudine. 1989. Molecular analysis of the human β-globin locus activation region. Proc. Natl. Acad. Sci. USA 86:5439-5443.
20. Gluzman, Y., and T. Shenk, 1983. Enhancers and eukaryotic gene expression. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
21. Grosveld, F., G. B. Van Assendelft, D. R. Greaves, and G. Kollias. 1987. Position independent, high-level expression of the human β-globin gene in transgenic mice. Cell 51:975-985.
22. Hug, B., R. Wesselschmidt, S. Fiering, R. Wesselschmidt, M. Bender, E. Epner, M. Groudine, and T. Ley. 1996. Analysis of mice containing a targeted deletion of β-globin locus control region 5' hypersensitive site 3. Mol. Cell. Biol. 16:2906-2912.
23. Ikuta, T., and Y. W. Kan. 1991. In vivo protein-DNA interactions at the β-globin gene locus. Proc. Natl. Acad. Sci. USA 88:10188-10192.
24. Kim, C., E. Epner, W. Forrester, and M. Groudine. 1992. Inactivation of the human β-globin gene by targeted insertion into the β-globin locus control region. Genes Dev. 6:928-938.
25. Kioussis, D., E. Vanin, T. DeLange, R. Flavell, and F. G. Grosveld. 1983. β-Globin gene inactivation by DNA translocation in γβ-thalassaemia. Nature 306:662-666.
26. Kirschbaum, B. J., P. Pognonec, and R. G. Roeder. 1992. Definition of the transcriptional activation domain of recombinant 43-kilodalton USF. Mol. Cell. Biol. 12:5094-5101.
27. 25a.Kong, S., et al. Unpublished data.
28. Lee, J. S., K. M. Galvin, and Y. Shi. 1993. Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1. Proc. Natl. Acad. Sci. USA 90:6145-6149.
29. Li, Q. L., P. Powers, and O. Smithies. 1985. Nucleotide sequence of 16-kilobase pairs of DNA 5' to the human ε-globin gene. J. Biol. Chem. 260: 14901-14910.
30. Lloyd, J. A., J. M. Krakowsky, S. C. Crable, and J. B. Lingrel. 1992. Human γ to β-globin gene switching using a mini construct in transgenic mice. Mol. Cell. Biol. 12:1561-1567.
31. Melton, D. A., P. A. Krieg, M. R. Rebagliati, T. Maniatis, K. Zinn, and M. R. Green. 1984. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12:7035-7056.
32. Mignotte, V., L. Wall, E. deBoer, F. Grosveld, and P. H. Romeo. 1989. Two tissue-specific factors bind the erythroid promoter of the human PBGD gene. Nucleic Acids Res. 17:37-54.
33. Miller, J., C. Walsh, P. Ney, J. Samulski, and A. Nienhuis. 1993. Single-copy transduction and expression of human γ-globin in K562 cells using recombinant adeno-associated virus vectors: the effect of mutations in NF-E2 and GATA-1 binding motifs within the HS2 enhancer. Blood 82:1900-1906.
34. Mitchell, P., and R. Tjian. 1989. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245:371-378.
35. Moi, P., and Y. W. Kan. 1990. Synergistic enhancement of globin gene expression by activator protein-1-like proteins. Proc. Natl. Acad. Sci. USA 87:9000-9004.
36. Morley, B. J., C. A. Abbott, J. A. Sharpe, J. Lida, P. S. Chan-Thomas, and W. G. Wood. 1992. A single β-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice. Mol. Cell. Biol. 12:2057-2066.
37. Ney, P., B. Sorrentino, K. McDonagh, and A. Nienhuis. 1990. Tandem Ap-1 binding sites within the human β-globin dominant control region function as an inducible enhancer in erythroid cells. Genes Dev. 4:993-1006.
38. Noguchi, T., K. Yamada, H. Inoue, T. Matsuda, and T. Tanaka. 1987. The L-and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters. J. Biol. Chem. 262:14316-14321.
39. Orkin, S. 1990. Globin gene regulation and switching: circa 1990. Cell 63: 665-672.
40. 37a.Promega. 1989. Technical bulletin 80. CAT reporter system. Promega, Madison, Wis.
41. Rahuel, C., A. Vignal, J. London, S. Hamel, P. H. Romeo, Y. Colin, and J. P. Cartron. 1989. Structure of the 5' flanking region of the gene encoding human glycophorin A and analysis of its multiple transcripts. Gene 85:471-477.
42. Reddy, P. M. S., and C. K. J. Shen. 1991. Protein-DNA interactions in vivo of an erythroid-specific, human β-globin locus enhancer. Proc. Natl. Acad. Sci. USA 88:8676-8680.
43. Reddy, P. M. S., G. Stamatoyannopoulos, T. Papayannopoulou, and C. K. Shen. 1994. Genomic footprinting and sequencing of human β-globin locus. J. Biol. Chem. 269:8287-8295.
44. Roy, A., M. Meisterernst, P. Pogonec, and R. Roeder. 1991. Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF. Nature 354:245-248.
45. Ryan, T. M., R. R. Behringer, N. C. Martin, T. M. Townes, R. D. Palmiter, and R. L. Brinster. 1989. A single erythroid-specific DNase I super-hypersensitive site activates high levels of human β-globin gene expression in transgenic mice. Genes Dev. 3:314-323.
46. Shaw, W. V., L. C. Packman, B. D. Burleigh, A. Dell, H. R. Morris, and B. S. Hartley. 1979. Primary structure of a chloramphenicol acetyltransferase. Nature 282:870-872.
47. Shi, Y., E. Seto, L. S. Chang, and T. Shenk. 1991. Transcriptional repression by YY1, a human GLI-kruppel-related protein and relief of repression by adenovirus E1A protein. Cell 67:377-388.
48. Shih, D., R. Wall, and S. Shapiro. 1993. A 5' control region of the human e-globin gene is sufficient for embryonic specificity in transgenic mice. J. Biol. Chem. 268:3066-3071.
49. Solomon, W., C. H. Lin, J. Palma, X. Y. Gao, and S. Wu. 1993. Suppression of a cellular differentiation program by phorbol esters coincides with inhibition of binding of a cell-specific transcription factor (NF-E2) to an enhancer required for expression of an erythroid-specific gene. J. Biol. Chem. 268:5089-5096.
50. Sorrentino, B., P. Ney, D. Bodine, and A. Nienhuis. 1990. A 46 base pair enhancer sequence within the locus activating region is required for induced expression of the γ-globin gene during erythroid differentiation. Nucleic Acids Res. 18:2721-2731.
51. Talbot, D., S. Philipsen, P. Fraser, and F. Grosveld. 1990. Detailed analysis of the site 3 region of the human β-globin dominant control region. EMBO J. 9:2169-2178.
52. Talbot, D., and F. Grosveld. 1991. The 5' HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites. EMBO J. 10:1391-1398.
53. Tuan, D., W. Salomon, Q. Li, and L. M. London. 1985. The β-Iike globin gene domain in human erythroid cells. Proc. Natl. Acad. Sci. USA 82:6384-6388.
54. Tuan, D., A. Abeliovich, M. Lee-Oldham, and D. Lee. 1987. Identification of regulatory elements of human β-like globin genes, p. 211-220. In G. Stamatoyannopoulos and A. Nienhuis (ed.). Developmental control of globin gene expression. Alan R. Liss, Inc., New York. N.Y.
55. Tuan, D. Y. H., W. B. Solomon, I. M. London, and D. P. Lee. 1989. An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "ß-like globin" genes. Proc. Natl. Acad. Sci. USA 86:2554-2558.
56. 52a.Tuan, D., W. Solomon, R. Cavallesco, G. Huang, and I. London. 1989. Characterization of a human globin enhancer element, p. 63-72. In G. Stamatoyannopoulos and A. Nienhuis (ed.), Hemoglobin switching. Part A. Transcriptional regulation. Alan R. Liss, Inc., New York, N.Y.
57. Tuan, D., S. Kong, and K. Hu. 1992. Transcription of the hypersensitive HS2 enhancer in erythroid cells. Proc. Natl. Acad. Sci. USA 89:11219-11223.
58. Walters, M., W. Magis, S. Fiering, J. Eidemiller, D. Scalzo, M. Groudine, and D. Martin. 1995. Transcriptional enhancers act in cis to suppress position-effect variegation. Genes Dev. 10:185-195.
59. Wang, L., C. Mizzen, C. Ying, R. Candau, N. Barlev, J. Browned, D. C. Allis, and S. L. Berger. 1997. Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation. Mol. Cell. Biol. 17:519-527.
60. Yoo, J., L. Herman, C. Li, S. Krantz, and D. Tuan. 1996. Dynamic changes in the locus control region of erythroid progenitor cells demonstrated by polymerase chain reaction. Blood 87:2558-2567.
61. Youssoufian, H., L. I. Zon, S. Orkin, A. D. D'Andrea, and H. F. Lodish. 1990. Structure and transcription of the mouse erythropoietin receptor gene. Mol. Cell. Biol. 10:3675-3682.