Nuclear localization and histone acetylation: A pathway for chromatin opening and transcriptional activation of the human β-globin locus

Genes and Development

Volumn 14, Issue 8, 2000, Pages 940-950

  Schübeler, Dirk ^a   Francastel, Claire ^a   Cimbora, Daniel M ^a   Reik, Andreas ^a   Martin, David I K ^b   Groudine, Mark ^a,c  

^a USA   (United States)

^b VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Acetylation; Gene activation; Globin; LCR; Nuclear compartmentalization

Indexed keywords

BETA GLOBIN; HISTONE H3; HISTONE H4;

ACETYLATION; ALLELE; ARTICLE; CELL NUCLEUS; CHROMATIN STRUCTURE; GENE ACTIVATION; GENE CLUSTER; GENE LOCUS; GENETIC TRANSCRIPTION; GLOBIN GENE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE;

ACETYLATION; ALLELES; ANIMALS; CELL NUCLEUS; CHROMATIN; GENE DELETION; GENE EXPRESSION REGULATION; GENE TARGETING; GLOBINS; HISTONES; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MODELS, GENETIC; MUTAGENESIS; PRECIPITIN TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0242439142     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Andrulis, E.D., A.M. Neiman, D.C. Zappulla, and R. Sternglanz. 1998. Perinuclear localization of chromatin facilitates transcriptional silencing. Nature 394: 592-595.
2. Armstrong, J.A., J.J. Bieker, and B.M. Emerson. 1998. A SWI/ SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. Cell 95: 93-104.
3. Bender, M., M. Bulger, J. Close, and M. Groudine. 2000. Globin gene switching and DNaseI sensitivity of the endogenous β-globin locus in mice do not require the Locus Control Region. Mol. Cell 5: 387-393.
4. Blobel, G.A., T. Nakajima, R. Eckner, M. Montminy, and S.H. Orkin. 1998. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc. Natl. Acad. Sci. 95: 2061-2066.
5. Braunstein, M., R.E. Sobel, C.D. Allis, B.M. Turner, and J.R. Broach. 1996. Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern. Mol. Cell. Biol. 16: 4349-4356.
6. Brown, K.E., S.S. Guest, S.T. Smale, K. Hahm, M. Merkenschlager, and A.G. Fisher. 1997. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 91: 845-854.
7. Brown, K.E., J. Baxter, D. Graf, M. Merkenschlager, and A.G. Fisher. 1999. Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division. Mol. Cell 3: 207-217.
8. Bulger, M. and M. Groudine. 1999. Looping versus linking: Toward a model for long-distance gene activation. Genes, & Dev. 13: 2465-2477.
9. Bulger, M., J.H. van Doorninck, N. Saitoh, A. Telling, C. Farrell, M.A. Bender, G. Felsenfeld, R. Axel, and M. Groudine. 1999. Conservation of sequence and structure flanking the mouse and human beta-globin loci: The beta-globin genes are embedded within an array of odorant receptor genes. Proc. Natl. Acad. Sci. 96:5129-5134.
10. Burgess, S.M., M. Ajimura, and N. Kleckner. 1999. GCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeast. Proc. Nat. Acad. Sci. 96: 6835-6840.
11. Chen, H., R.J. Lin, W. Xie, D. Wilpitz, and R.M. Evans. 1999. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 98: 675-686.
12. Cheng, X., M.J. Reginato, N.C. Andrews, and M.A. Lazar. 1997. The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2. Mol. Cell. Biol. 17: 1407-1416.
13. Chien, C.T., S. Buck, R. Sternglanz, and D. Shore. 1993. Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast. Cell 75: 531-541.
14. Choi, O.R. and J.D. Engel. 1988. Developmental regulation of beta-globin gene switching. Cell 55:17-26.
15. Cockell, M. and S.M. Gasser. 1999. Nuclear compartments and gene regulation. Curr. Opin. Genet. Dev. 9: 199-205.
16. Cosma, M.P., T. Tanaka, and K. Nasmyth. 1999. Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter. Cell 97: 299-311.
17. Csink, A.K. and S. Henikoff. 1996. Genetic modification of heterochromatic association and nuclear organization in Drosophila. Nature 381: 529-531.
18. Davie, J.R. 1998. Covalent modifications of histones: Expression from chromatin templates. Curr. Opin. Genet. Dev. 8: 173-178.
19. Dhar, V., D. Mager, A. Iqbal, and C.L. Schildkraut. 1988. The coordinate replication of the human beta-globin gene domain reflects its transcriptional activity and nuclease hypersensitivity. Mol. Cell. Biol. 8: 4958-4965.
20. Dieken, E.S., E.M. Epner, S. Fiering, R.E. Fournier, and M. Groudine. 1996. Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids. Nat. Genet. 12: 174-182.
21. Epner, E., A. Reik, D. Cimbora, A. Telling, M.A. Bender, S. Fiering, T. Enver, D.I. Martin, M. Kennedy, G. Keller, and M. Groudine. 1998. The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus. Mol. Cell 2: 447-455.
22. Felsenfeld, G. 1996. Chromatin unfolds. Cell 86: 13-19.
23. Forrester, W.C., E. Epner, M.C. Driscoll, T. Enver, M. Brice, T. Papayannopoulou, and M. Groudine. 1990. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Genes & Dev. 4: 1637-1649.
24. Francastel, C., M.C. Walters, M. Groudine, and D.I.K. Martin. 1999. A functional enhancer suppresses silencing of a transgene and prevents its localization close to centromeric heterochromatin. Cell 99: 259-269.
25. Fraser, P. and F. Grosveld. 1998. Locus control regions, chromatin activation and transcription. Curr. Opin. Cell Biol. 10: 361-365.
26. Gotta, M. and S.M. Gasser. 1996. Nuclear organization and transcriptional silencing in yeast. Experientia 52: 1136-1147.
27. Gross, D.S. and W.T. Garrard. 1988. Nuclease hypersensitive sites in chromatin. Annu. Rev. Biochem. 57: 159-197.
28. Hebbes, T.R., A.L. Clayton, A.W. Thorne, and C. Crane-Robinson. 1994. Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain. EMBO J. 13: 1823-1830.
29. Hebbes, T.R., A.W. Thorne, and C. Crane-Robinson. 1988. A direct link between core histone acetylation and transcriptionally active chromatin. EMBO J. 7: 1395-1402.
30. Hendrich, B. and A. Bird. 1998. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol. Cell. Biol. 18: 6538-6547.
31. Imhof, A. and A.P. Wolffe. 1998. Transcription: Gene control by targeted histone acetylation. Curr. Biol. 8: R422-R424.
32. Johnson, C.A., L.P. O'Neill, A. Mitchell, and B.M. Turner. 1998. Distinctive patterns of histone H4 acetylation are associated with defined sequence elements within both heterochromatic and euchromatic regions of the human genome. Nucleic Acids Res. 26: 994-1001.
33. Keohane, A.M., L.P. O'Neill, N.D. Belyaev, J.S. Lavender, and B.M. Turner. 1996. X-Inactivation and histone H4 acetylation in embryonic stem cells. Dev. Biol. 180: 618-630.
34. Kim, J., S. Sif, B. Jones, A. Jackson, J. Koipally, E. Heller, S. Winandy, A. Viel, A. Sawyer, T. Ikeda et al. 1999. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 10: 345-355.
35. Kipling, D., H.E. Wilson, A.R. Mitchell, B.A. Taylor, and H.J. Cooke. 1994. Mouse centromere mapping using oligonucleotide probes that detect variants of the minor satellite. Chromosoma 103: 46-55.
36. Kuo, M.H. and C.D. Allis. 1998. Roles of histone acetyltransferases and deacetylases in gene regulation. BioEssays 20: 615-626.
37. Lewis, J.D., R.R. Meehan, W.J. Henzel, I. Maurer-Fogy, P. Jeppesen, F. Klein, and A. Bird. 1992. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 69: 905-914.
38. Madisen, L., A. Krumm, T.R. Hebbes, and M. Groudinc. 1998. The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes. Mol. Cell. Biol. 18: 6281-6292.
39. Maillet, L., C. Boscheron, M. Gotta, S. Marcand, E. Gilson, and S.M. Gasser. 1996. Evidence for silencing compartments within the yeast nucleus: A role for telomere proximity and Sir protein concentration in silencer-mediated repression. Genes & Dev. 10: 1796-1811.
40. O'Neill, L.P. and B.M. Turner. 1995. Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner. EMBO J. 14: 3946-3957.
41. Orlando, V., H. Strutt, and R. Paro. 1997. Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods 11: 205-214.
42. Parekh, B.S. and T. Maniatis. 1999. Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter. Mol. Cell 3: 125-129.
43. Reik, A., A. Telling, G. Zitnik, D. Cimbora, E. Epner, an M. Groudine. 1998. The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells. Mol. Cell. Biol. 18: 5992-6000.
44. Stalder, J., A. Larsen, J.D. Engel, M. Dolan, M. Groudine, and H. Weintraub. 1980. Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNAase I. Cell 20: 451-460.
45. Struhl, K. 1998. Histone acetylation and transcriptional regulatory mechanisms. Genes & Dev. 12: 599-606.
46. Weintraub, H. and M. Groudine. 1976. Chromosomal subunits in active genes have an altered conformation. Science 193: 848-856.
47. Zhang, W. and J.J. Bieker. 1998. Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc. Natl. Acad. Sci. 95: 9855-9860.