β-globin Gene switching and DNase I sensitivity of the endogenous β-globin locus in mice do not require the locus control region

Molecular Cell

Volumn 5, Issue 2, 2000, Pages 387-393

  Bender, M A ^a,b   Bulger, Michael ^a   Close, Jennie ^a   Groudine, Mark ^a,b  

^a USA   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHROMATIN STRUCTURE; GENE DELETION; GENE EXPRESSION; GENE LOCUS; GENE STRUCTURE; GENE SWITCHING; GLOBIN GENE; HUMAN; MOUSE; NONHUMAN; PROTEIN CONFORMATION; PROTEIN MODIFICATION;

ANIMALIA;

EID: 0033861846     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80433-5     Document Type: Article

References (43)

1. Participation of the human beta-globin locus control region in initiation of DNA replication
2. A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro
3. Description and targeted deletion of 5' hypersensitive site 5 and 6 of the mouse beta-globin locus control region
4. Looping vs. linking: Toward a model for long-distance gene activation
5. Conservation of sequence and structure flanking the mouse and human beta-globin loci: The beta-globin genes are embedded within an array of odorant receptor genes
6. Mouse model of human beta zero thalassemia: Targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells
7. Nucleosome disruption precedes transcription and is largely limited to the transcribed domain of globin genes in murine erythroleukemia cells
8. A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia
9. Deletion and replacement of the mouse adult beta-globin genes by a 'plug and socket' repeated targeting strategy
10. Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites
11. The β-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse β-globin locus
12. Analysis of mammalian cis-regulatory elements by homologous recombination
13. Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus
14. A developmentally stable chromatin structure in the human beta-globin gene cluster
15. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus
16. A functional enhancer suppresses silencing of a transgene and prevents its localization close to centromeric heterochromatin
17. Mechanisms of developmental regulation in globin loci
18. Mechanisms of developmental regulation in globin loci
19. Locus control regions, chromatin activation and transcription
20. Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice
21. Activation by locus control regions?
22. Position-independent, high-level expression of the human beta-globin gene in transgenic mice
23. Human fetal to adult hemoglobin switching: Changes in chromatin structure of the beta-globin gene locus
24. Locus control regions of mammalian beta-globin gene clusters: Combining phylogenetic analyses and experimental results to gain functional insights
25. Do LCRs open chromatin domains?
26. Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3
27. Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation
28. Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA
29. Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulation
30. Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in phasmacytoma and Burkitt's lymphoma cells
31. The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes
32. Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles
33. Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease
34. The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells
35. Developmental regulation of topisomerase II sites and DNase I-hypersensitive sites in the chicken beta-globin locus
36. A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice
37. Knockout-transgenic mouse model of sickle cell disease
38. Gene expression in murine erythroleukemia cells. Transcriptional control and chromatin structure of the alpha 1-globin gene
39. Hemoglobin switching
40. Developmental regulation of human gamma- and beta-globin genes in the absence of the locus control region
41. Gamma delta beta-thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human beta-globin cluster
42. The 'beta-like-globin' gene domain in human erythroid cells
43. A mouse model for beta 0-thalassemia