Intergenic transcription in the human β-globin gene cluster

Molecular and Cellular Biology

Volumn 21, Issue 19, 2001, Pages 6507-6514

  Plant, K E ^a   Routledge, S J E ^a   Proudfoot, N J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; HISTONE DEACETYLASE; TRICHOSTATIN A;

ARTICLE; CELL MATURATION; ERYTHROID CELL; GENE CLUSTER; GENE CONTROL; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; LONG TERMINAL REPEAT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RETROVIRUS; TRANSGENIC MOUSE;

5' UNTRANSLATED REGIONS; ANIMALS; DNA, INTERGENIC; ENZYME INHIBITORS; ERYTHROCYTES; GLOBINS; HELA CELLS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; LOCUS CONTROL REGION; MICE; MICE, TRANSGENIC; MODELS, GENETIC; MULTIGENE FAMILY; RNA, MESSENGER; TERMINAL REPEAT SEQUENCES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0034811678     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.19.6507-6514.2001     Document Type: Article

References (35)

1. Synthesis of a gene for the HIV transactivator protein Tat by a novel single stranded approach involving invivo gap repair
2. Beta-globin YAC transgenes exhibit uniform expression levels but position effect variegation in mice
3. Intergenic transcription and transinduction of the human beta-globin locus
4. The locus control region far upstream of the human P-like globin genes is transcribed in erythroid cells in a direction toward the globin genes
5. Conservation of sequence and structure flanking the mouse and human beta-globin loci: The beta-globin genes are embedded within an array of odorant receptor genes
6. Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation
7. A human RNA polymerase II complex containing factors that modify chromatin structure
8. Multiple transcript cleavage precedes polymerase release in termination by RNA polymerase II
9. Poly(A) signals and transcriptional pause sites combine to prevent interference between RNA polymerase-II promoters
10. The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus
11. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus
12. Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta globin locus
13. Position-independent, high-level expression of the human beta-globin gene in transgenic mice
14. Dependence of globin gene-expression in mouse erythroleukemia-cells on the NF-E2 heterodimer
15. Identification and characterization of novel human endogenous retroviral sequences preferentially expressed in undifferentiated embryonal carcinoma-cells
16. Identification of regulatory elements within the minimal promoter region of the human endogenous ERV9 proviruses: Accurate transcription is controlled by an Inr-like element
17. Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly
18. A long terminal repeat of the human endogenous retrovirus ERV-9 is located in the 5' boundary area of the human beta-globin locus control region
19. Amplification of cDNA ends based on template-switching effect and step-out PCR
20. Differential in vivo activation of the class II and class III snRNA genes by the POU-specific domain of Oct-1
21. Transcription factors and hematopoietic development
22. The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells
23. Intergenic transcription occurs throughout the human IL-4/IL-13 gene cluster
24. The language of covalent histone modifications
25. Developmental regulation of a complete 70-Kb human beta-globin locus in transgenic mice
26. The 5'HS2 of the globin locus-control region enhances transcription through the interaction of a multimeric complex binding at 2 functionally distinct NF-E2 binding-sites
27. Effects of altered gene order or orientation of the locus control region on human beta-globin gene expression in mice
28. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian-cells
29. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
30. Transcription of the hypersensitive site HS2 enhancer in erythroid cells
31. Hybridisation in the analysis of RNA
32. RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling
33. A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme
34. Potent and specific inhibition of mammalian histone deacetylase both in vitro and in vitro by trichostatin A