Hypersensitive site 2 specifies a unique function within the human β- globin locus control region to stimulate globin gene transcription

Molecular and Cellular Biology

Volumn 19, Issue 4, 1999, Pages 3062-3072

  Bungert, Jörg ^a,b   Tanimoto, Keiji ^a   Patel, Sunil ^a   Liu, Qinghui ^a   Fear, Mark ^a   Engel, James Douglas ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; DEOXYRIBONUCLEASE I; TYPE I SITE SPECIFIC DEOXYRIBONUCLEASE;

ANIMAL CELL; ARTICLE; CHROMATIN; GENETIC TRANSCRIPTION; GLOBIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSGENIC MOUSE; YEAST ARTIFICIAL CHROMOSOME;

ANIMALIA; MUS MUSCULUS;

EID: 0032912801     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.19.4.3062     Document Type: Article

References (51)

1. Aladjem, M. I., M. Groudine, L. L. Brody, E. S. Dieken, R. E. Fournier, G. M. Wahl, and E. M. Epner. 1995. Participation of the human β-globin locus control region in initiation of DNA replication. Science 270:815-819.
2. Bonifer, C., M. Vidal, F. Grosveld, and A. E. Sippel. 1990. Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice. EMBO J. 9:2843-2848.
3. Bresnick, E., and L. Tze. 1997. Synergism between hypersensitive sites confers long-range gene activation by the β-globin locus control region. Proc. Natl. Acad. Sci. USA 94:4566-4571.
4. Bungert, J., U. Dave, K. E. Lieuw, K.-C. Lim, J. A. Shavit, Q. Liu, and J. D. Engel. 1995. Synergistic regulation of human β-globin gene switching by locus control region elements HS3 and HS4. Genes Dev. 9:3083-3096.
5. Caterina, J., T. M. Ryan, R. D. Pawlik, R. L. Brinster, R. R. Behringer, and T. M. Townes. 1991. Human β-globin locus control region: analysis of the 5′ DNase 1 hypersensitive site HS 2 in transgenic mice. Proc. Natl. Acad. Sci. USA 88:1626-1630.
6. Choi, O.-R., and J. D. Engel. 1988. Developmental regulation of β-globin gene switching. Cell 55:17-26.
7. Collis, P., M. Antoniou, and F. Grosveld. 1990. Definition of the minimal requirements within the human β-globin gene and the dominant control region for high level expression. EMBO J. 9:233-240.
8. Ellis, J., D. Talbot, N. Dillon, and F. Grosveld. 1993. Synthetic human β-globin 5′ HS2 constructs function as locus control regions only in multicopy transgene concatemers. EMBO J. 12:127-134.
9. Ellis, J., U. K. Tan, A. Harper, D. Michalovich, N. Yannoutsos, S. Philipsen, and F. Grosveld. 1996. A dominant chromatin-opening activity in 5′ hypersensitive site 3 of the human beta-globin locus control region. EMBO J. 15:562-568.
10. Engel, J. D. 1993. Developmental regulation of human β-globin gene transcription: a switch of loyalties? Trends Genet. 9:304-309.
11. Fiering, S., E. E. Epner, K. Robinson, Y. Zhuang, A. Telling, M. Hu, D. I. K. Martin, T. Enver, T. J. Ley, and M. Groudine. 1995. Targeted deletion of 5′HS2 of the murine β-globin LCR reveals that it is not essential for proper regulation of the β-like globin locus. Genes Dev. 9:2203-2213.
12. Forrester, W. C., E. Epner, M. C. Driscoll, T. Enver, M. Brice, T. Papayannopoulou, and M. Groudine. 1990. A deletion of the human β-globin locus activation region causes a major alteration in chromatin structure and replication across the entire β-globin locus. Genes Dev. 4:1637-1649.
13. Forrester, W. C., S. Takegawa, T. Papayannopoulou, G. Stammatoyannopoulos, and M. Groudine. 1987. Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids. Nucleic Acids Res. 15:10159-10177.
14. Forrester, W. C., C. Thompson, J. T. Elder, and M. Groudine. 1986. A developmentally stable chromatin structure in the human β-globin gene cluster. Proc. Natl. Acad. Sci. USA 83:1359-1363.
15. Fraser, P., J. Hurst, P. Collis, and F. Grosveld. 1990. DNase1 hypersensitive sites 1, 2 and 3 of the human β-globin dominant control region direct position-independent expression. Nucleic Acids Res. 18:3503-3508.
16. Fraser, P., S. Pruzina, and F. Grosveld. 1993. Each hypersensitive site of the human β-globin locus control region confers a different developmental pattern of expression to the globin genes. Genes Dev. 7:106-113.
17. Gaensler, K. M. L., M. Burmeister, B. H. Brownstein, P. Taillon-Miller, and R. M. Myers. 1991. Physical mapping of yeast artificial chromosomes containing sequences from the human β-globin gene region. Genomics 10:976-984.
18. Globin Gene Server Website. 15 May 1994, posting date. [Online.] Pennsylvania State University. http://globin.cse.psu.edu. [4 December 1998, last date accessed.]
19. Greaves, D. R., F. D. Wilson, G. Lang, and D. Kioussis. 1989. Human CD2 3′-flanking sequences confer high-level. T cell-specific, position-independent gene expression in transgenic mice. Cell 56:979-986.
20. Grosveld, F., M. Antoniou, M. Berry, E. deBoer, N. Dillon, J. Ellis, P. Fraser, O. Hanscombe, J. Hurst, A. Imam, M. Lindenbaum, S. Philipsen, S. Pruzina, S. Strouboulis, S. Raguz-Bolognesi, and D. Talbot. 1993. The regulation of human globin gene switching. Philos. Trans. R. Soc. Lond. Ser. B 339:183-191.
21. Grosveld, F., G. B. van Assendelft, D. R. Greaves, and G. Kollias. 1987. Position-independent, high-level expression of the human β-globin gene in transgenic mice. Cell 51:975-985.
22. Hanscombe, O., D. Whyatt, P. Fraser, N. Yannoutsos, D. Greaves, N. Dillon, and F. Grosveld. 1991. Importance of globin gene order for correct developmental expression. Genes Dev. 5:1387-1394.
23. Hardison, R., J. L. Slightom, D. L. Gumucio, M. Goodman, N. Stojanovic, and W. Miller. 1997. Locus control regions of mammalian β-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights. Gene 205:73-94.
24. Higgs, D. R., W. G. Wood, A. P. Jarman, J. Sharpe, J. Lida, I.-M. Pretorius, and H. Ayyub. 1990. A major positive regulatory region located far upstream of the human α-globin gene locus. Genes Dev. 4:1588-1601.
25. Igarashi, K., H. Hoshino, A. Muto, N. Suwabe, S. Nishikawa, H. Nakauchi, and M. Yamamoto. 1998. Multivalent DNA binding complex generated by small maf and bach1 as a possible biochemical basis for β-globin locus control region complex. J. Biol. Chem. 273:11783-11790.
26. Jackson, J. D., W. Miller, and R. C. Hardison. 1996. Sequences within and flanking hypersensitive sites 3 and 2 of the β-globin locus control region required for synergistic versus additive interaction with the ε-globin gene promoter. Nucleic Acids Res. 24:4327-4335.
27. Jackson, J. D., H. Petrykowska, S. Philipsen, W. Miller, and R. Hardison. 1996. Role of DNA sequences outside the cores of DNase hypersensitive sites (HSs) in functions of the β-globin locus control region: domain opening and synergism between HS2 and HS3. J. Biol. Chem. 271:11871-11878.
28. Kitsberg, D., S. Selig, I. Keshet, and H. Cedar. 1993. Replication structure of the human β-globin gene domain. Nature 366:588-590.
29. Konkel, D. A., S. M. Tilghman, and P. Leder. 1978. The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites. Cell 15:1125-1132.
30. Li, G., K. C. Lim, J. D. Engel, and J. Bungert. 1998. Individual LCR hypersensitive sites cooperate to generate an open chromatin domain spanning the human β-globin locus. Genes Cells 3:415-430.
31. Liu, Q., J. Bungert, and J. D. Engel. 1997. Mutation of gene-proximal regulatory elements disrupts human ε-, γ-and β-globin expression in YAC transgenic mice. Proc. Natl. Acad. Sci. USA 94:169-174
32. Liu, Q., K. Tanimoto, J. Bungert, and J. D. Engel. 1998. The Aγ-globin 3′ element provides no unique function(s) for β-globin locus gene regulation. Proc. Natl. Acad. Sci. USA 95:9944-9949.
33. Martin, D. I. K., S. Fiering, and M. Groudine. 1996. Regulation of β-globin gene expression: straightening out the locus. Curr. Opin. Genet. Dev. 6:488-495.
34. Merika, M., and S. H. Orkin. 1995. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol. Cell. Biol. 15:2437-2447.
35. Milot, E., J. Strouboulis, T. Trimborn, M. Wijgerde, E. deBoer, A. An Langeveld, K. Tan-Un, W. Vergeer, N. Yannoutsos, F. Grosveld, and P. Fraser. 1996. Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. Cell 87:105-114.
36. Montoliu, L., T. Umland, and G. Schütz. 1996. A locus control region at - 12 kb of the tyrosinase gene. EMBO J. 14:6026-6034.
37. Moon, A. M., and T. J. Ley. 1991. Functional properties of the beta-globin locus control region in K562 erythroleukemia cells. Blood 77:2272-2284.
38. Motohashi, H., J. A. Shavit, K. Igarashi, M. Yamamoto, and J. D. Engel. 1997. The world according to maf. Nucleic Acids Res. 25:2953-2960.
39. Navas, P. A., K. R. Peterson, Q. Li, E. Skarpidi, A. Rohde, S. E. Shaw, C. H. Clegg, H. Asano, and G. Stamatoyannopoulos. 1998. Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion. Mol. Cell. Biol. 17:4188-4196.
40. Ney, P. A., B. P. Sorrentino, K. T. McDonagh, and A. W. Nienhuis. 1990. Tandem AP-1-binding sites within the human β-globin dominant control region function as an inducible enhancer in erythroid cells. Genes Dev. 4:993-1006.
41. Orkin, S. 1995. Regulation of globin gene expression in erythroid cells. Eur. J. Biochem. 231:271-281.
42. Ortiz, B. D., D. Cado, V. Chen, P. W. Diaz, and A. Winoto. 1997. Adjacent DNA elements dominantly restrict ubiquitous activity of a novel chromatin-opening region to specific tissues. EMBO J. 16:5037-5045.
43. Osada, H., G. Grutz, H. Axelson, A. Forster, and T. H. Rabbitts. 1995. Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc finger protein GATA1. Proc. Natl Acad. Sci. USA 92:9585-9589.
44. Oyake, T., K. Itoh, H. Motohashi, N. Hayashi, H. Hoshino, M. Nishizawa, M. Yamamoto, and K. Igarashi. 1996. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with mafK and regulate transcription through the NF-E2 site. Mol. Cell. Biol. 16:6083-6095.
45. Peterson, K. R., C. H. Clegg, P. A. Navas, E. J. Norton, T. G. Kimbrough, and G. Stamatoyannopoulos. 1996. Effect of deletion of 5′HS3 or 5′HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice. Proc. Natl. Acad. Sci. USA 93:6605-6609.
46. Stamatoyannopoulos, G., and A. W. Neinhuis. 1994. Hemoglobin switching, p. 107-155. In G. Stamatoyannopoulos, A. W. Neinhuis, P. Majerus, and H. Varmus (ed.), The molecular basis of blood diseases, 2nd ed. The W. B. Saunders Co., Philadelphia, Pa.
47. Talbot, D., S. Philipsen, P. Fraser, and F. Grosveld. 1990. Detailed analysis of the site 3 region of the human β-globin dominant control region. EMBO J. 9:2169-2178.
48. Tanimoto, K., Q. Liu, J. Bungert, and J. D. Engel. Submitted for publication.
49. Tuan, D., W. Solomon, Q. Li, and I. M. London. 1985. The 'β-like globin' gene domain in human erythroid cells. Proc. Natl. Acad. Sci. USA 82:6384-6388.
50. Tuan, D. Y., W. B. Solomon, I. M. London, and D. P. Lee. 1989. An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes. Proc. Natl. Acad. Sci. USA 86:2554-8.
51. Wijgerde, M., F. Grosveld, and P. Fraser. 1995. Transcription complex stability and chromatin dynamics in vivo. Nature 377:209-213.