T lymphocyte activation - An inside overview

Acta Medica Austriaca

Volumn 29, Issue 1, 2002, Pages 7-13

  Aringer, Martin ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Signal transduction; T cell receptor; Transcription factors

Indexed keywords

CD28 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; RECEPTOR; STAT PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT;

APOPTOSIS; AUTOIMMUNE DISEASE; CELL ASSAY; CELLULAR PARAMETERS; HUMAN; PATHOGENESIS; PROMOTER REGION; REVIEW; RHEUMATIC DISEASE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; PROMOTER REGIONS (GENETICS); RECEPTORS, INTERLEUKIN-2; RHEUMATIC DISEASES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0036047674     PISSN: 03038173     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1563-2571.2002.01044.x     Document Type: Review

References (90)

1. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation
2. In vivo regulation of interleukin-2 receptor alpha gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells
3. Janus kinases and their role in growth and disease
4. Interleukin/Interferon signaling: A 1999 perspective
5. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
6. Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development
7. Immunologic parameters in systemic sclerosis
8. Costimulatory regulation of T cell function
9. Expression of IL-2R, IL-4R, IL-6R on peripheral blood lymphocytes in systemic lupus erythematosus and correlation with disease activity: A prospective study
10. Conversion of Bcl-2 to a Bax-like death effector by caspases
11. Cbl-b regulates the CD28 dependence of T-cell activation
12. TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway
13. Predominance of CD8+ T lymphocytes in psoriatic arthritis
14. The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways
15. Signal transduction by the JNK group of MAP kinases
16. Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
17. Signaling takes shape in the immune system
18. Effector pathways regulating T cell activation
19. Characterization and regulation of CD69 expression on rheumatoid arthritis synovial fluid T cells
20. Cyclosporin A and iloprost treatment of systemic sclerosis: Clinical results and intefieukin-6 serum changes after 12 months of therapy
21. Organization and regulation of mitogen-activated protein kinase signaling pathways
22. Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
23. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
24. CD28/B7 costimulation: A review
25. Increase in activated T cells and reduction in suppressor inducer T cells in systemic sclerosis
26. A nuclear protein tyrosine phosphatase is required for the inactivation of Statl
27. Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex
28. The Jak-STAT pathway: Cytokine signalling from the receptor to the nucleus
29. HLA-DR, DQ and DP antigen expression in synovial fluid T lymphocytes in rheumatoid arthritis: Cell cycle analysis of HLA-DP positive T cells
30. STAT structure and function in signaling
31. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins
32. Signaling-2000 and beyond
33. Signaling by the cytokine receptor superfamily
34. CD45 is a JAK phospharase and negatively regulates cytokine receptor signalling
35. Inhibition of death receptor signals by cellular FLIP
36. Regulation of cell-type-specific intefieukin-2 receptor alpha-chain gene expression: Potential role of physical interactions between Elf-l, HMGI(Y), and NF-kappa B family proteins
37. The significance of tetramerization in promoter recruitment by Stat5
38. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
39. How NF-kappaB is activated: The role of the IkappaB kinase (IKK) complex
40. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases
41. Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation
42. Differential clustering of CD4 and CD3zeta during T cell recognition
43. Intefieukin-15 up-regulates interleukin-2 receptor alpha chain but down-regulates its own high-affinity binding sites on human T and B cells
44. Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease
45. RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter
46. From TCR engagement to T cell activation: A kinetic view of T cell behavior
47. GrpL, a Grb2-related adaptor protein, interacts with SLP76 to regulate nuclear factor of activated T cell activation
48. Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene
49. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
50. IL-15 and IL-2: A matter of life and death for T cells in vivo
51. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases
52. Epithelial HLA-DR expression and T lymphocyte subsets in salivary glands in Sjogren's syndrome
53. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
54. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
55. Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells
56. Kinetic proofreading in T-cell receptor signal transduction
57. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
58. Fas ligand-induced apoptosis
59. NF-AT components define a family of transcription factors targeted in T-cell activation
60. Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions
61. Key molecules involved in receptor-mediated lymphocyte activation
62. Signal transduction in T lymphocytes
63. CD47 signals T cell death
64. NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase
65. Abnormalities in CD69 expression, cytosolic pH and Ca2+ during activation of lymphocytes from patients with systemic lupus erythematosus
66. Apoptosis: The importance of being eaten
67. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration
68. Apoptosis signaling in lymphocytes
69. Elf-1 contributes to the function of the complex interleukin (IL)-2-responsive enhancer in the mouse IL-2 receptor alpha gene
70. The architecture of the interleukin-2 promoter: A reflection of T lymphocyte activation
71. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: A double-blind, randomised, multicentre trial
72. Anti-dsDNA production coincides with concurrent B and T cell activation during development of active disease in systemic lupus erythematosus (SLE)
73. Approaches to the management of systemic lupus erythematosus
74. JNK is involved in signal integration during costimulation of T lymphocytes
75. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
76. Long-term treatment of lupus nephritis with cyclosporin A
77. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
78. Subsets of activated T cells in patients with systemic lupus erythematosus: The relation to cell cycle
79. An unusual mechanism for ligand antagonism
80. Autologous haematopoietic stem cell transplants for autoimmune disease - Feasibility and transplant-related mortality
81. The PI3K-PDK1 connection: More than just a road to PKB
82. A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation
83. Spontaneous in vivo gene transcription of interleukin-2, interleukin-3, interleukin-4, intedeukin-6, interferon-gamma, intedeukin-2 receptor (CD25) and proto-oncogene c-myc by rheumatoid synovial T lymphocytes
84. T cell co-stimulatory molecules other than CD28
85. Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation
86. Transcriptional repression of the IL-2 gene in Th cells by ZEB
87. T-cell co-stimulation through B7RP-1 and ICOS
88. Progression of joint damage in early active severe rheumatoid arthritis during 18 months of treatment: Comparison of lowdose cyclosporin and parenteral gold
89. Posttranslational Nmyristoylation of BID as a molecular switch for targeting mitochondria and apoptosis
90. Functional association of Nmi with Stat5 and Statl in IL-2- and IFN gamma-mediated signaling