메뉴 건너뛰기




Volumn 8, Issue 5, 1998, Pages 582-587

STAT structure and function in signaling

Author keywords

[No Author keywords available]

Indexed keywords

STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; STAT5B PROTEIN; TRANSCRIPTION FACTOR;

EID: 0032191341     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(98)80015-4     Document Type: Article
Times cited : (88)

References (51)
  • 1
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to interferons and other extracellular signaling proteins
    • Darnell JE Jr, Kerr IA, Stark GR. Jak-STAT pathways and transcriptional activation in response to interferons and other extracellular signaling proteins. Science. 264:1994;1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell J.E., Jr.1    Kerr, I.A.2    Stark, G.R.3
  • 2
    • 0030765924 scopus 로고    scopus 로고
    • Jaks, STATs, cytokines, signal transduction, and immunoregulation: Are we there yet?
    • O'Shea JJ. Jaks, STATs, cytokines, signal transduction, and immunoregulation: are we there yet? Immunity. 7:1997;1-11.
    • (1997) Immunity , vol.7 , pp. 1-11
    • O'Shea, J.J.1
  • 3
    • 0030807903 scopus 로고    scopus 로고
    • SH2 signaling in a lower eukaryote: A Stat protein that regulates stalk cell differentiation in Dictyostelium
    • of outstanding interest. This paper identifies a key transcriptional regulator that mediates cell - cell communication as a member of the STAT family. As Dictyosetelium is one of the most primitive multicellular organisms, it appears that STATs arose early in evolution as means of signal transduction. The most conserved regions between the Dictyostelium and mammalian STAT proteins are the DNA-binding domain and the SH2 domain.
    • Kawata T, Shevchenko A, Fukuzawa M, Jermyn KA, Totty NF, Zhukovskaya NV, Sterling AE, Mann M, Williams JG. SH2 signaling in a lower eukaryote: a Stat protein that regulates stalk cell differentiation in Dictyostelium. of outstanding interest Cell. 89:1997;909-916 This paper identifies a key transcriptional regulator that mediates cell - cell communication as a member of the STAT family. As Dictyosetelium is one of the most primitive multicellular organisms, it appears that STATs arose early in evolution as means of signal transduction. The most conserved regions between the Dictyostelium and mammalian STAT proteins are the DNA-binding domain and the SH2 domain.
    • (1997) Cell , vol.89 , pp. 909-916
    • Kawata, T.1    Shevchenko, A.2    Fukuzawa, M.3    Jermyn, K.A.4    Totty, N.F.5    Zhukovskaya, N.V.6    Sterling, A.E.7    Mann, M.8    Williams, J.G.9
  • 4
    • 0001514956 scopus 로고    scopus 로고
    • Identification of a STAT gene that functions in Drosophila development
    • Yan R, Small S, Desplan C, Dearolf CR, Darnell JE Jr. Identification of a STAT gene that functions in Drosophila development. Cell. 84:1996;421-430.
    • (1996) Cell , vol.84 , pp. 421-430
    • Yan, R.1    Small, S.2    Desplan, C.3    Dearolf, C.R.4    Darnell J.E., Jr.5
  • 5
    • 0030040691 scopus 로고    scopus 로고
    • Marelle acts downstream of the Drosophila HOP/Jak kinase and encodes a protein similar to the mammalian STATs
    • Hou XS, Melnick MB, Perrimon N. marelle acts downstream of the Drosophila HOP/Jak kinase and encodes a protein similar to the mammalian STATs. Cell. 84:1996;411-419.
    • (1996) Cell , vol.84 , pp. 411-419
    • Hou, X.S.1    Melnick, M.B.2    Perrimon, N.3
  • 6
    • 0032504232 scopus 로고    scopus 로고
    • Mutational analysis of the STAT6 SH2 domain
    • of special interest. This paper reports a complete alanine-scanning mutagenesis of the STAT6 SH2 domain. Amino acids specifically required for cytokine receptor binding or dimerization are identified, providing a functional map of the STAT class of SH2 domain.
    • Mikita T, Daniel C, Wu P, Schindler U. Mutational analysis of the STAT6 SH2 domain. of special interest J Biol Chem. 273:1998;17634-17642 This paper reports a complete alanine-scanning mutagenesis of the STAT6 SH2 domain. Amino acids specifically required for cytokine receptor binding or dimerization are identified, providing a functional map of the STAT class of SH2 domain.
    • (1998) J Biol Chem , vol.273 , pp. 17634-17642
    • Mikita, T.1    Daniel, C.2    Wu, P.3    Schindler, U.4
  • 7
    • 0032577678 scopus 로고    scopus 로고
    • Crystal structure of a STAT-1 dimer bound to DNA
    • of outstanding interest. This paper provides the first structural analysis of a STAT-DNA complex. The DNA-binding domain has the structure of the immunoglobulin fold, similar to NF-κB and p53. The SH2 domain is structurally very similar to src, despite the lack of sequence homology outside the phosphotyrosine-binding pocket.
    • Chen X, Vinkemeir U, Zhao Y, Jeruzalmi D, Darnell JE Jr, Kuriyan J. Crystal structure of a STAT-1 dimer bound to DNA. of outstanding interest Cell. 93:1998;827-839 This paper provides the first structural analysis of a STAT-DNA complex. The DNA-binding domain has the structure of the immunoglobulin fold, similar to NF-κB and p53. The SH2 domain is structurally very similar to src, despite the lack of sequence homology outside the phosphotyrosine-binding pocket.
    • (1998) Cell , vol.93 , pp. 827-839
    • Chen, X.1    Vinkemeir, U.2    Zhao, Y.3    Jeruzalmi, D.4    Darnell J.E., Jr.5    Kuriyan, J.6
  • 8
    • 0028913109 scopus 로고
    • A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
    • Horvath CM, Wen Z, Darnell JE Jr. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 9:1995;984-994.
    • (1995) Genes Dev , vol.9 , pp. 984-994
    • Horvath, C.M.1    Wen, Z.2    Darnell J.E., Jr.3
  • 9
    • 0029001660 scopus 로고
    • Components of a Stat recognition code: Evidence for two layers of molecular selectivity
    • Schindler U, Wu P, Rothe M, Brasseur M, McKnight SL. Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity. 2:1995;689-697.
    • (1995) Immunity , vol.2 , pp. 689-697
    • Schindler, U.1    Wu, P.2    Rothe, M.3    Brasseur, M.4    McKnight, S.L.5
  • 10
    • 0029069145 scopus 로고
    • Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
    • Schindler C, Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem. 64:1995;621-651.
    • (1995) Annu Rev Biochem , vol.64 , pp. 621-651
    • Schindler, C.1    Darnell J.E., Jr.2
  • 11
    • 0028937707 scopus 로고
    • Spacing of the palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity
    • Seidel HM, Milocco LH, Lamb P, Darnell JE Jr, Stein RB, Rosen J. Spacing of the palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc Natl Acad Sci USA. 92:1995;3041-3045.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3041-3045
    • Seidel, H.M.1    Milocco, L.H.2    Lamb, P.3    Darnell J.E., Jr.4    Stein, R.B.5    Rosen, J.6
  • 13
    • 0029739627 scopus 로고    scopus 로고
    • Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino terminal domain
    • Xu X, Sun Y-L, Hoey T. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino terminal domain. Science. 273:1996;794-797.
    • (1996) Science , vol.273 , pp. 794-797
    • Xu, X.1    Sun, Y.-L.2    Hoey, T.3
  • 14
    • 0032512661 scopus 로고    scopus 로고
    • Structure of the amino terminal protein interaction domain of STAT4
    • of outstanding interest. The amino-terminal domain of STAT4 mediates dimer - dimer interactions and cooperative DNA binding to adjacent sites. This domain is composed of a series of helices that form a hook-like structure capable of dimerizing.
    • Vinkemeier U, Moarefi I, Darnell JE, Kuriyan J. Structure of the amino terminal protein interaction domain of STAT4. of outstanding interest Science. 279:1998;1048-1052 The amino-terminal domain of STAT4 mediates dimer - dimer interactions and cooperative DNA binding to adjacent sites. This domain is composed of a series of helices that form a hook-like structure capable of dimerizing.
    • (1998) Science , vol.279 , pp. 1048-1052
    • Vinkemeier, U.1    Moarefi, I.2    Darnell, J.E.3    Kuriyan, J.4
  • 17
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong Z, Darnell JE Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell. 82:1995;241-250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell J.E., Jr.3
  • 18
    • 0030792590 scopus 로고    scopus 로고
    • A family of cytokine-inducible inhibitors of signalling
    • of special interest. The authors use a retroviral gene transfer system to identify genes that inhibit IL-6 signaling, leading to the discovery of the SOCS family.
    • Starr R, Willson TA, Viney EM, Murray LJL, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ. A family of cytokine-inducible inhibitors of signalling. of special interest Nature. 387:1997;917-921 The authors use a retroviral gene transfer system to identify genes that inhibit IL-6 signaling, leading to the discovery of the SOCS family.
    • (1997) Nature , vol.387 , pp. 917-921
    • Starr, R.1    Willson, T.A.2    Viney, E.M.3    Murray, L.J.L.4    Rayner, J.R.5    Jenkins, B.J.6    Gonda, T.J.7    Alexander, W.S.8    Metcalf, D.9    Nicola, N.A.10    Hilton, D.J.11
  • 21
    • 13144258732 scopus 로고    scopus 로고
    • Twenty proteins containing a C-terminal SOCS box from five structural classes
    • of special interest. This study identifies many new SOCS-box-containing proteins through database searching: several are similar to SOCS-1, containing an SH2 domain and a carboxy-terminal SOCs box; other members lack an SH2 domain but have other types of protein - protein interaction domains.
    • Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA. Twenty proteins containing a C-terminal SOCS box from five structural classes. of special interest Proc Natl Acad Sci USA. 95:1998;114-119 This study identifies many new SOCS-box-containing proteins through database searching: several are similar to SOCS-1, containing an SH2 domain and a carboxy-terminal SOCs box; other members lack an SH2 domain but have other types of protein - protein interaction domains.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 114-119
    • Hilton, D.J.1    Richardson, R.T.2    Alexander, W.S.3    Viney, E.M.4    Willson, T.A.5    Sprigg, N.S.6    Starr, R.7    Nicholson, S.E.8    Metcalf, D.9    Nicola, N.A.10
  • 22
    • 0028972719 scopus 로고
    • Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain containing tyrosine phosphatase SHPTP1
    • David M, Chen HE, Goelz S, Larner AC, Neel BG. Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain containing tyrosine phosphatase SHPTP1. Mol Cell Biol. 15:1995;7050-7058.
    • (1995) Mol Cell Biol , vol.15 , pp. 7050-7058
    • David, M.1    Chen, H.E.2    Goelz, S.3    Larner, A.C.4    Neel, B.G.5
  • 23
    • 0029973560 scopus 로고    scopus 로고
    • Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain containing protein tyrosine phosphatase SHP-1
    • Jiao H, Berrada K, Yang W, Tabrizi M, Platanias LC, Yi T. Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain containing protein tyrosine phosphatase SHP-1. Mol Cell Biol. 16:1996;6985-6992.
    • (1996) Mol Cell Biol , vol.16 , pp. 6985-6992
    • Jiao, H.1    Berrada, K.2    Yang, W.3    Tabrizi, M.4    Platanias, L.C.5    Yi, T.6
  • 24
    • 0030945444 scopus 로고    scopus 로고
    • Mapping of the cytoplasmic domain of the human growth hormone receptor that regulates rates of inactivation of Jak2 and Stat proteins
    • Hackett RH, Wang YD, Switzer S, Feldman G, Wood WI, Larner AC. Mapping of the cytoplasmic domain of the human growth hormone receptor that regulates rates of inactivation of Jak2 and Stat proteins. J Biol Chem. 272:1997;11128-11132.
    • (1997) J Biol Chem , vol.272 , pp. 11128-11132
    • Hackett, R.H.1    Wang, Y.D.2    Switzer, S.3    Feldman, G.4    Wood, W.I.5    Larner, A.C.6
  • 25
    • 0030582671 scopus 로고    scopus 로고
    • The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP?
    • Sharenberg AM, Kinet JP. The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP? Cell. 87:1996;961-964.
    • (1996) Cell , vol.87 , pp. 961-964
    • Sharenberg, A.M.1    Kinet, J.P.2
  • 26
    • 0029972194 scopus 로고    scopus 로고
    • The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase
    • Haspel RL, Salditt-Georgieff M, Darnell JE Jr. The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. EMBO J. 15:1996;6262-6268.
    • (1996) EMBO J , vol.15 , pp. 6262-6268
    • Haspel, R.L.1    Salditt-Georgieff, M.2    Darnell J.E., Jr.3
  • 27
    • 0029742102 scopus 로고    scopus 로고
    • Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1
    • Shuai K, Liao J, Song MM. Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1. Mol Cell Biol. 16:1996;4932-4941.
    • (1996) Mol Cell Biol , vol.16 , pp. 4932-4941
    • Shuai, K.1    Liao, J.2    Song, M.M.3
  • 28
    • 0000413462 scopus 로고    scopus 로고
    • Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway
    • Kim TK, Maniatis T. Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science. 273:1996;1717-1719.
    • (1996) Science , vol.273 , pp. 1717-1719
    • Kim, T.K.1    Maniatis, T.2
  • 29
    • 0030725378 scopus 로고    scopus 로고
    • Specific inhibition of Stat3 signal transduction by PIAS3
    • of outstanding interest. An inhibitor of STAT3 DNA binding is identified. As PIAS3 is a member of a family of related proteins and does not interact with STAT1, it may be that specific PIAS proteins exist for each of the STATs. The exploration of how PIAS proteins inhibit STAT DNA binding and how their expression and activity is regulated will be hot topics in the field.
    • Chung CD, Liao J, Liu B, Rao X, Jay P, Berta P, Shuai K. Specific inhibition of Stat3 signal transduction by PIAS3. of outstanding interest Science. 278:1997;1803-1805 An inhibitor of STAT3 DNA binding is identified. As PIAS3 is a member of a family of related proteins and does not interact with STAT1, it may be that specific PIAS proteins exist for each of the STATs. The exploration of how PIAS proteins inhibit STAT DNA binding and how their expression and activity is regulated will be hot topics in the field.
    • (1997) Science , vol.278 , pp. 1803-1805
    • Chung, C.D.1    Liao, J.2    Liu, B.3    Rao, X.4    Jay, P.5    Berta, P.6    Shuai, K.7
  • 31
    • 0031005027 scopus 로고    scopus 로고
    • Synergy between interferon-γ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal tranducer and activator of transcription 1 and nuclear factor κB
    • Ohmori Y, Schreiber RD, Hamilton TA. Synergy between interferon-γ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal tranducer and activator of transcription 1 and nuclear factor κB. J Biol Chem. 272:1997;14899-14907.
    • (1997) J Biol Chem , vol.272 , pp. 14899-14907
    • Ohmori, Y.1    Schreiber, R.D.2    Hamilton, T.A.3
  • 32
    • 0029075875 scopus 로고
    • Cooperative transcriptional of Jun and Stat3β, a short form of STAT3
    • Shaefer TS, Sanders LK, Nathans D. Cooperative transcriptional of Jun and Stat3β, a short form of STAT3. Proc Natl Acad Sci USA. 92:1995;9097-9101.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9097-9101
    • Shaefer, T.S.1    Sanders, L.K.2    Nathans, D.3
  • 33
    • 0032513202 scopus 로고    scopus 로고
    • Autoregulation of the Stat3 gene through cooperation with a cAMP-responsive element binding protein
    • Ichiba M, Nakajima K, Yamnaka Y, Kiuchi N, Hirano T. Autoregulation of the Stat3 gene through cooperation with a cAMP-responsive element binding protein. J Biol Chem. 273:1998;6132-6138.
    • (1998) J Biol Chem , vol.273 , pp. 6132-6138
    • Ichiba, M.1    Nakajima, K.2    Yamnaka, Y.3    Kiuchi, N.4    Hirano, T.5
  • 34
    • 0030667790 scopus 로고    scopus 로고
    • STAT3 acts as a co-activator of glucocorticoid receptor signaling
    • Zhang Z, Jones S, Hagood JS, Fuentes NL, Fuller GM. STAT3 acts as a co-activator of glucocorticoid receptor signaling. J Biol Chem. 272:1997;30607-30610.
    • (1997) J Biol Chem , vol.272 , pp. 30607-30610
    • Zhang, Z.1    Jones, S.2    Hagood, J.S.3    Fuentes, N.L.4    Fuller, G.M.5
  • 35
    • 0029851231 scopus 로고    scopus 로고
    • Functional interactions between STAT5 and the glucocorticoid receptor
    • Stocklin E, Wissler M, Goilleux F, Groner B. Functional interactions between STAT5 and the glucocorticoid receptor. Nature. 383:1996;726-728.
    • (1996) Nature , vol.383 , pp. 726-728
    • Stocklin, E.1    Wissler, M.2    Goilleux, F.3    Groner, B.4
  • 36
    • 0032529415 scopus 로고    scopus 로고
    • Synergistic activation of the germline epsilon promoter mediated by STAT6 and C/EBPβ
    • Mikita T, Kurama M, Schnindler U. Synergistic activation of the germline epsilon promoter mediated by STAT6 and C/EBPβ J Immunol. 161:1998;1822-1828.
    • (1998) J Immunol , vol.161 , pp. 1822-1828
    • Mikita, T.1    Kurama, M.2    Schnindler, U.3
  • 39
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin JE, Hackenmiller R, Simon MC, Levy DE. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell. 84:1996;443-450.
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 42
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and development of Th2 cells in STAT4-deficient mice
    • Kaplan MH, Sun Y-L, Hoey T, Grusby MJ. Impaired IL-12 responses and development of Th2 cells in STAT4-deficient mice. Nature. 382:1996;174-177.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.-L.2    Hoey, T.3    Grusby, M.J.4
  • 44
    • 0028284762 scopus 로고
    • Stat3 and Stat4: Members of the family of signal transducers and activators of transcription
    • Zhong Z, Wen Z, Darnell JE Jr. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci USA. 91:1994;4806-4810.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4806-4810
    • Zhong, Z.1    Wen, Z.2    Darnell J.E., Jr.3
  • 47
    • 0030930196 scopus 로고    scopus 로고
    • STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression
    • Feldman GM, Rosentahl LA, Liu X, Hayes MP, Wynshaw-Boris A, Leonard WJ, Henninghausen L, Finbloom DS. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood. 90:1997;1768-1776.
    • (1997) Blood , vol.90 , pp. 1768-1776
    • Feldman, G.M.1    Rosentahl, L.A.2    Liu, X.3    Hayes, M.P.4    Wynshaw-Boris, A.5    Leonard, W.J.6    Henninghausen, L.7    Finbloom, D.S.8
  • 49
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
    • Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity. 4:1996;313-319.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.