Expression of IL-2R, IL-4R, IL-6R on peripheral blood lymphocytes in systemic lupus erythematosus and correlation with disease activity: A prospective study

Journal of Clinical Pathology

Volumn 49, Issue 8, 1996, Pages 660-663

  Chan, E Y T ^a   Lau, C S ^b   Zola, H ^c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b Department of Medicine ^*

^c WOMEN S AND CHILDREN S HOSPITAL   (Australia)

Author keywords

Cytokine receptors; Peripheral blood lymphocytes; Systemic lupus erythematosus

Indexed keywords

CYTOKINE; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 4 RECEPTOR ALPHA; INTERLEUKIN 6 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0029788923     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.49.8.660     Document Type: Article

References (24)

1. Cuadrado MJ, Marubayashi M, Ortega C, Fernandez-Arcas N, Garcia-Cozar F, Pena J, et al. Relationship of IL-2, IL-2R (CD25+), soluble IL-2R and IL-4 with disease activity in SLE patients. Lupus 1993;2:257-60.
2. Alcocer-Varela J, Alarcon-Segovia D. Decreased production of interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus. J Clin Invest 1982; 69:1388-92.
3. Huang YP, Miescher PA, Zubler RH. The interleukin-2 secretion defect in vitro in systemic lupus erythematosus is reversible in rested cultured T cells. J Immunol 1986; 137:3515-20.
4. Razziudin S, Al Janadi MA, Wabell AA. Soluble IL-2 receptor levels in serum and its relationship to T cell abnormality and clinical manifestations of the disease in patients with SLE. J Rheumatol 1991;18:831-6.
5. Ter-Borg EJ, Horst G, Limburg PC, Kallenberg CG. Changes in plasma levels of interleukin-2 receptor in relation to disease exacerbations and levels of anti-dsDNA and complement in systemic lupus erythematosus. Clin Exp Immunol 1990;82:21-6.
6. Wigfall DR, Sakai RS, Wallace DJ, Jordan SC. Interleukin-2 receptor expression in peripheral blood lymphocytes from systemic lupus erythematosus patients: relationship to clinical activity. Clin Immunol Immunopathol 1982;47:354-62.
7. Alcocer-Varela J, Alarcon-Riqualme M, Laffon A, Sachez-Madrid F, Alarcon-Segovia AD. Activation markers on peripheral blood T cells from patients with active or inactive systemic lupus erythematosus. Correlation with proliferative responses and production of IL-2. J Autoimmun 1991;4:935-45.
8. Spronk PE, v.d. Gun BT, Limburg PC, Kallenberg CG. B cell activation in clinically quiescent systemic lupus erythematosus (SLE) is related to immunoglobulin levels, but not to levels of anti-dsDNA, nor to concurrent T cell activation. Clin Exp Immunol 1993;93:39-44.
9. Via CS, Handwerger BS. B cell and T cell function in systemic lupus erythematosus. Curr Opin Rheumatol 1993; 5:570-4.
10. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH. Derivation of the SLEDAI. A disease activity index for lupus patients. Arthritis Rheum 1992;35:630-40.
11. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25:1271-7.
12. Zola H, Flego L, Sheldon A. Detection of cytokine receptors by high-sensitivity immunofluorescence flow cytometry. Immunobiology 1992;185:350-65.
13. Huang YP, Perrin LH, Miescher PA, Zubler RA. Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus. J Immunol 1988; 141:827-33.
14. Ishida H, Kumagai S, Umehara H, Sano H, Tagaya Y, Yodoi J, et al. Impaired expression of high affinity interleukin 2 receptor on activated lymphocytes from patients with systemic lupus erythematosus. J Immunol 1987;139:1070-4.
15. Amasaki Y, Kobayashi S, Takeda T, Ogura N, Jodo S, Nakabayashi T, et al. Up-regulated expression of Fas antigen (CD95) by peripheral naive and memory T cell subsets in patients with systemic lupus erythematosus (SLE): a possible mechanism for lymphopenia. Clin Exp Immunol 1995;99:245-50.
16. Emlen W, Niebur J, Kadera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 1994;152:3685-92.
17. Janossy G, Borthwick N, Lomnitzer R, Medina E, Squire E, Phillips AN, et al. Lymphocyte activation in HIV-1 infection. I. Predominant proliferative defects among CD45RO+ cells of the CD4 and CD8 lineages. AIDS 1993;7:613-24.
18. Taniguchi T, Minami Y. The IL-2/IL-2 receptor system: a curret overview. Cell 1993;73:5-8.
19. Ishii N, Takeshita T, Kimura Y, Tada K, Kondo M, Nakamura M, et al. Expression of the IL-2 receptor y chain on various populations in human peripheral blood. Int Immunol 1994;6:1273-7.
20. Sheldon A, Flego L, Zola H. Coexpression of IL-2 receptor p55 and p75 by circulating blood lymphocytes. J Leukocyte Biol 1993;54:161-7.
21. Tanaka T, Saiki O, Negoro S, Igarashi T, Kuritani T, Hara H, et al. Decreased expression of interleukin-2 binding molecules (p70/75) in T cells from patients with systemic lupus erythematosus. Arthritis Rheum 1989;32:552-9.
22. Linker-Isreali M, Deans RJ, Wallace DJ, Prehn J, Ozeri-Chen T, Klinenber JR. Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. J Immunol 1991;147:117-23.
23. Al-Janadi M, Raziuddin S. B cell hyperactivity is a function of T cell derived cytokines in systemic lupus erythematosus. J Rheumatol 1993;20:1885-91.
24. Nagafuchi H, Suzuki N, Mizushima A, Sakane T Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus. J Immunol 1993;151:6525-34.