Adult T Cell Leukemia (ATL)-Derived Factor/Human Thioredoxin Prevents Apoptosis of Lymphoid Cells Induced by L-Cystine and Glutathione Depletion: Possible Involvement of Thiol-Mediated Redox Regulation in Apoptosis Caused by Pro-Oxidant State

Journal of Immunology

Volumn 158, Issue 7, 1997, Pages 3108-3117

  Iwata, Satoshi ^a   Hori, Toshiyuki ^a   Sato, Norihito ^a   Hirota, Kiichi ^a   Sasada, Tetsuro ^a   Mitsui, Akira ^b   Hirakawa, Tadashi ^b   Yodoi, Junji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b AJINOMOTO CO INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT T CELL LEUKEMIA DERIVED FACTOR; ADULT T CELL LEUKEMIA-DERIVED FACTOR; CATALASE; CYSTINE; CYTOKINE; GLUTATHIONE; HYDROGEN PEROXIDE; OXIDIZING AGENT; RECOMBINANT PROTEIN; THIOL DERIVATIVE; THIOREDOXIN; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; CELL LINE; CELL SURVIVAL; CULTURE MEDIUM; DRUG EFFECT; GENETICS; HUMAN; LYMPHOCYTE; METABOLISM; MOLECULAR WEIGHT; OXIDATION REDUCTION REACTION;

APOPTOSIS; CATALASE; CELL LINE; CELL SURVIVAL; CULTURE MEDIA; CYSTINE; CYTOKINES; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; LYMPHOCYTES; MOLECULAR WEIGHT; NEOPLASM PROTEINS; OXIDANTS; OXIDATION-REDUCTION; RECOMBINANT PROTEINS; SULFHYDRYL COMPOUNDS; THIOREDOXIN;

EID: 0031114040     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Dröge, W., H. P. Eck, H. Naher, U. Pekar, and V. Daniel. 1988. Abnormal amino acid concentration in the blood of patients with acquired immunodeficiency syndrome (AIDS) may contribute to the immunological defect. Biol. Chem. Hoppe-Seyler 369:143.
2. Eck, H. P., H. Gmünder, M. Hartmann, D. Petzoidt, V. Daniel, and W. Dröge. 1989. Low concentrations of acid-soluble thiol (cysteine) in the blood plasma of HIV-1-infected patients. Biol. Chem. Hoppe-Seyler 370:101.
3. Buhl, R., H. A. Jaffe, K. J. Holroyd, F. B. Wells, A. Mastrangeli, C. Saltini, A. M. Cantin, and R. G. Crystal. 1989. Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet 2:1294.
4. Wu, J., E. M. Levy, and P. H. Black. 1989. 2-Mercaptoethanol and n-acetylcysteine enhance T cell colony formation in AIDS and ARC. Clin. Exp. Immunol. 77:7.
5. Roederer, M., F. J. T. Staal, H. Osada, L. A. Herzenberg, and L. A. Herzenberg. 1991. CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses. Int. Immunol. 3:933.
6. Buttke, T. M., and P. A. Sandstorm. 1994. Oxidative stress as a mediator of apoptosis. Immunol. Today 15:7.
7. Sandstorm, P. A., B. Roberts, T. M. Folks, and T. M. Buttke. 1993. HIV gene expression enhances T cell susceptibility to hydrogen peroxide-induced apoptosis. AIDS Res. Hum. Retroviruses 9:1107.
8. Fanger, M. W., D. A. Hart, J. V. Wells, and A, Nisonoff. 1970. Enhancement by reducing agents of the transformation of human and rabbit peripheral lymphocytes. J. Immunol. 105:1043.
9. Broome, J. D., and M, W. Jeng. 1973. Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro. J. Exp. Med. 138:574.
10. Hewllet, G., H. G. Optiz, H. D. Schlumberger, and H. Lemke. 1977. Growth regulation of a murine lymphoma cell line by a 2-mercaptoethanol or macrophage-activated serum factor. Eur. J. Immunol. 7:781.
11. Chen, C., and J. G. Hirsch. 1972. The effects of mercaptoethanol and of peritoneal macrophages on the antibody-forming capacity of nonadherent mouse spleen cells in vitro. Science 176:60.
12. Kavanagh, T. J., A. Grossmann, E. P. Jaecks, J. C. Jinneman, D. L. Eaton, G. M. Martin, and P. S. Rabinovitch. 1990. Proliferative capacity of human peripheral blood lymphocytes sorted on the basis of glutathione content. J. Cell. Physiol. 145:472.
13. Suthanthiran, M., M. E. Anderson, Y. Sharma, and A. Meister. 1990. Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 Ags. Proc. Natl. Acad. Sci. USA 87:3343.
14. Messina, J. P., and D. A. Lawrence. 1989. Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase. J. Immunol. 143:1974.
15. Fidelus, R. K., P. Ginouves, D. Lawrence, and M. F. Tsan. 1987. Modulation of intracellular glutathione concentrations alters lymphocyte activation and proliferation. Exp. Cell Res. 170:269.
16. Dröge, W., C. Pottmeyer-Gerber, H. Schmit, and S. Nick. 1986. Glutathione augments the activation of cytotoxic T lymphocytes in vivo. Immunobiology 172:151.
17. Yamauchi, A., and E. T. Bloom. 1993. Requirement of thiol compounds as reducing agents for IL-2 mediated induction of LAK activity and proliferation of human NK cells. J. Immunol. 151:5535.
18. Teshigawara, K., M. Maeda, K. Nishino, T. Nikaido, T. Uchiyama, M. Tsudo, M. Wano, and J. Yodoi. 1985. Adult T cell leukemia cells produce a lymphokine that augments interleukin 2 receptor expression. J. Mol. Cell. Immunol. 2:17.
19. Okada, M., M. Maeda, Y. Tagaya, Y. Taniguchi, K. Teshigawara, T. Yoshiki, T. Diamantstein, K. A. Smith, T. Uchiyama, T. Honjo, and J. Yodoi. 1985. TCG-F(IL-2)-receptor inducing factor(s). II. Possible role of ATL-derived factor (ADF) on constitutive IL-2 receptor expression of HTLV-I(+) T cell lines. J. Immunol. 135:3995.
20. Tagaya, Y., Y. Taniguchi, M. Naramura, M. Okada, N. Suzuki, H. Kanamori, T. Nikaido, T. Honjo, and J. Yodoi. 1987. Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-(+) T-cell lines. Immunol. Lett. 15:221.
21. Tagaya, Y., M. Okada, K. Sugie, T. Kasahara, N. Kondo, J. Hamuro, K. Matsushima, C. A. Dinarello, and J. Yodoi. 1988. IL-2 receptor(p55)/Tac inducing factor: purification and characterization of ATL-derived factor (ADF). J. Immunol. 140:2614.
22. Tagaya, Y., Y. Maeda, A. Mitsui, N. Kondo, H. Matsui, J. Hamuro, N. Brown, K. Arai, T. Yokota, H. Wakasugi, and J. Yodoi. 1989. ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin: possible involvement of dithiol-reduction in the IL-2 receptor induction. EMBO J. 8:757.
23. Holmgren, A., I. Ohlsson, and M. L. Grankvist. 1978. Thioredoxin from Escherichia coli. J. Biol. Chem. 253:430.
24. Holmgren, A. 1985. Thioredoxin. Annu. Rev. Biochem. 54:237.
25. Holmgren, A. 1989. Thioredoxin and glutaredoxin systems. J. Biol. Chem. 264: 13963.
26. Mitsui, A., T. Hirakawa, and J. Yodoi. 1992. Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor (ADF)/human thioredoxin. Biochem. Biophys. Res. Commun. 186:1220.
27. Matsuda, M., H. Masutani, H. Nakamura, S. Miyajima, A. Yamauchi, S. Yonehara, A. Uchida, K. Irimajiri, A. Horiuchi, and J. Yodoi. 1991. Protective activity of adult T cell leukemia-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells. J. Immunol. 147:3837.
28. Nakamura, H., M. Matsuda, K. Furuke, Y. Kitaoka, S. Iwata, K. Toda, T. Inamoto, Y. Yamaoka, K. Ozawa, and J. Yodoi. 1994. Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide. Immunol. Lett. 42:75.
29. Furuke, K., H. Nakamura, T. Hori, S. Iwata, N. Maekawa, T. Inamoto, Y. Yamaoka, and J. Yodoi. 1995. Suppression of ADF/human thioredoxin induction by FK506 and cyclosporin A: a new mechanism of immune modulation via redox control. Int. Immunol. 7:985.
30. Iwata, S., T. Hori, N. Sato, Y. U. Taniguchi, T. Yamabe, H. Nakamura, H. Masutani, and J. Yodoi. 1994. Thiol-mediated redox regulation of lymphocyte proliferation: possible involvement of adult T cell leukemia-derived factor and glutathione in transferrin receptor expression. J. Immunol. 152:5633.
31. Ellman, G. L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82:70.
32. Nicoletti, L., G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyle apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139:271.
33. Bass, D. A., J. W. Parce, L. R. Dechatelet, P. Szejda, M. C. Seeds, and M. Thomas. 1983. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J. Immunol. 130:1910.
34. Bannai, S., and E. Kitamura. 1980. Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture. J. Biol. Chem. 255:2372.
35. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265.
36. Akerboom, T. P. M., and H. Sies. 1981. Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Methods Enymol. 77:373.
37. Holmgren, A. 1979. Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide. J. Biol. Chem. 254:9627.
38. Lennon, S. V., S. J. Martin, and T. G. Cotter. 1991. Dose-dependent induction of apoptosis in human tumor cell lines by widely diverging stimuli. Cell Prolif. 24:203.
39. Sato, N., S. Iwata, K. Nakamura, T. Hori, K. Mori, and J. Yodoi. 1995. Thiol-mediated redox regulation of apoptosis: possible roles of cellular thiols other than glutathione in T cell apoptosis. J. Immunol. 154:3194.
40. Chae, H. Z., S. J. Chung, and S. G. Rhee. 1994. Thioredoxin-dependent peroxide reductase from yeast. J. Biol. Chem. 269:27670.
41. Ishii, T., S. Bannai, and Y. Sugita. 1981. Mechanism of growth stimulation of L1210 cells by 2-mercaptoethanol in vitro. J. Biol. Chem. 256:12387.
42. Bannai, S. 1984. Transport of cystine and cysteine in mammalian cells. Biochim. Biophys. Acta 779:289.
43. Ishii, T., I. Hishinuma, S. Bannai, and Y. Sugita. 1981. Mechanism of growth promotion of mouse lymphoma L1210 cells in vitro by feeder layer or 2-mercaptoethanol. J. Cell. Physiol. 107:283.
44. Dröge, W., H. P. Eck, H. Gmünder, and S. Mihm. 1991. Modulation of lymphocyte functions and immune responses by cysteine and cysteine derivatives. Am. J. Med. 91:140S.
45. Oxender, D. L., and H. N. Christensen. 1963. Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cells. J. Biol. Chem. 238:3686.
46. Kalebic, T., A. Kinter, G. Poli, M. E. Anderson, A. Meister, and A. S. Fauci. 1981. Suppression of HIV expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine. Proc. Natl. Acad. Sci. USA 88:986.
47. Schreck, R., P. Rieben and P. A. Baeuerle. 1991. Reactive oxygen intermediate as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J. 10:2247.
48. Mihm, S., J. Ennen, U. Pessara, R. Kurth, and W. Dröge. 1991. Inhibition of HIV-1 replication and NF-κB activity by cysteine and cysteine derivatives. AIDS 5:497.
49. Dröge, W., H. P. Eck, and S. Mihm. 1992. HIV-induced cysteine deficiency and T-cell dysfunction - a rationale for treatment with N-acetylcysteine. Immunol. Today 13:211.
50. Staal, F. J. T., M. Roederer, L. A. Herzenberg, and L. A. Herzenberg. 1990. Intracellular thiols regulate activation of nuclear factor κB and transcription of human immuodeficiency virus. Proc. Natl. Acad. Sci. USA 87:9943.
51. Roederer, M., F. J. T. Staal, P. A. Raju, S. W. Ela, L. A. Herzenberg, and L. A. Herzenberg. 1990. Cytokine-stimulated HIV replication is inhibited by N-acetyl-cysteine. Proc. Natl. Acad. Sci. USA 87:4884.
52. Sandstorm, P. A., and T. M. Buttke. 1993. Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free medium. Proc. Natl Acad. Sci. USA 90:4708.
53. Okamoto, T., H. Ogiwara, T. Hayashi, A. Mitsui, T. Kawabe, and J. Yodoi. 1992. Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism. Int. Immunol. 4:811.
54. Matthews, J. R., N. Wakasugi, J. L. Virelizier, J. Yodoi, and R. T. Hay. 1992. Thioredoxin regulates the DNA binding activity of NF-κB by reduction of a disulphide bond involving cysteine 62. Nucleic Adds Res. 20:3821.
55. Qin, J., G. M. Clore, W. M. P. Kennedy, J. R. Huth, and A. M. Gronenborn. 1995. Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFκB. Structure 3:289.
56. Masutani, H., M. Naito, K. Takahashi, T. Hattori, A. Koito, K. Takatsuki, T. Go, H. Nakamura, S. Fujii, Y. Yoshida, M. Okuma, and J. Yodoi. 1992. Dysregulation of adult T cell leukemia derived factor (ADF/thioredoxin in HIV infection: loss of ADF high producer cells in lymphoid tissues of AIDS patients. AIDS Res. Hum. Retroviruses 8:1707.
57. Newman, G. W., M. K. Balcewicz-Sablinska, J. R. Guarnaccia, H. G. Remold, and D. S. Silberstein. 1994. Opposing regulatory effects of thioredoxin and eosinophil cytotoxicity-enhancing factor on the development of human immunodeficiency virus 1. J. Exp. Med. 180:359.
58. Yodoi, J., and T. Uchiyama. 1992. Diseases associated with HTLV-I: virus, IL-2 receptor dysregulation and redox regulation. Immunol. Today 13:405.