Tumor necrosis factor α induces BID cleavage and bypasses antiapoptotic signals in prostate cancer LNCap cells

Cancer Research

Volumn 61, Issue 6, 2001, Pages 2713-2719

  Kulik, George ^a   Carson, Jonathan P ^a   Vomastek, Tomas ^a   Overman, Kevin ^a   Gooch, Barry D ^a   Srinivasula, Srinivasa ^c   Alnemri, Emad ^c   Nunez, Gabriel ^b   Weber, Michael J ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 9; CYTOCHROME C; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASE 9; CASPASES; CHROMONES; CYTOCHROME C GROUP; ENZYME ACTIVATION; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; HUMANS; MALE; MITOCHONDRIA; MORPHOLINES; PROSTATIC NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035866821     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma
2. Apoptosis and other mechanisms in androgen ablation treatment and androgen independent progression of prostate cancer: A review
3. Biochemical and pathological effects of 8 months of neoadjuvant androgen withdrawal therapy before radical prostatectomy in patients with clinically confined prostate cancer
4. Basic science aspects of prostate cancer
5. Target to apoptosis: A hopeful weapon for prostate cancer
6. Inhibition of apoptotic signaling pathways in cancer cells as a mechanism of chemotherapy resistance
7. Apoptosis regulating genes in prostate cancer
8. Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers
9. Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo
10. Antiapoptotic signaling in LNCaP prostate cancer cells: A survival signaling pathway independent of phosphatidylinositol 3′-kinase and Akt/protein kinase B
11. Modulation of cellular apoptotic potential: Contributions to oncogenesis
12. Androgens induce resistance to bcl-2-mediated apoptosis in LNCaP prostate cancer cells
13. Neuroendocrine peptides in the prostate
14. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
15. Homozygous deletion of the PTEN tumor suppressor gene in a subset of prostate adenocarcinomas
16. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
17. PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate
18. The phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells
19. Death receptors: Signaling and modulation
20. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
21. Mitochondria and apoptosis
22. The Ced-3/interleukin 1β converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2α are substrates for the apoptotic mediator CPP32
23. Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons
24. Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I
25. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
26. Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27
27. Two CD95 (APO-1/Fas) signaling pathways
28. Tumor necrosis factor-α and Fas activate complementary Fas-associated death domain-dependent pathways that enhance apoptosis induced by γ-irradiation
29. Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines
30. Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP
31. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
32. Signaling pathway activated during apoptosis of the prostate cancer cell line LNCaP: Overexpression of caspase-7 as a new gene therapy strategy for prostate cancer
33. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
34. A novel BH3-like domain in BID is required for intramolecular interaction and autoinhibition of pro-apoptotic activity
35. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death
36. Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation
37. Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B
38. NF-κB is a target of AKT in anti-apoptotic PDGF signalling
39. Dominant nature of the resistance to Fas- and tumor necrosis factor-α-mediated apoptosis in human prostatic carcinoma cell lines
40. Fas-mediated apoptosis in human prostatic carcinoma cell lines
41. Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis
42. Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis
43. A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis
44. Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis
45. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
46. Tumor necrosis factor-α sensitizes prostate cancer cells to γ-irradiation-induced apoptosis