Inhibition of p53 tumor suppressor by viral interferon regulatory factor

Journal of Virology

Volumn 75, Issue 16, 2001, Pages 7572-7582

  Nakamura, H ^a   Li, M ^a   Zarycki, J ^a   Jung, J U ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; INTERFERON REGULATORY FACTOR; PROTEIN P53; UNCLASSIFIED DRUG;

ACETYLATION; ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA BINDING; HERPES VIRUS; HUMAN; HUMAN CELL; KAPOSI SARCOMA; LYMPHOMA; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; VIRUS INFECTION;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION, VIRAL; GENES, P53; GENES, TUMOR SUPPRESSOR; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 8, HUMAN; HUMANS; INTERFERONS; VIRUS REPLICATION;

EID: 0034898890     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.16.7572-7582.2001     Document Type: Article

References (45)

1. Enhanced phosphorylation of p53 by ATM in response to DNA damage
2. Reversal of p53-induced cell-cycle arrest
3. Mechanisms of p53-mediated apoptosis
4. Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300
5. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas
6. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
7. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
8. Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor
9. p21/p53, cellular growth control and genomic integrity
10. Definition of a consensus binding site for p53
11. WAF1, a potential mediator of p53 tumor suppression
12. Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma
13. KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway
14. A simplified system for generating recombinant adenoviruses
15. The p53 paradox in the pathogenesis of tumor progression
16. Cellular targets of the oncoproteins encoded by the cancer associated human papillomaviruses
17. p53 mutation spectrum and load: The generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer
18. Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors
19. Covalent and noncovalent modifiers of the p53 protein
20. Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins
21. New HPV E6 binding proteins: Dangerous liaisons?
22. T antigen is bound to a host protein in SV40-transformed cells
23. Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen
24. The p53 tumor suppressor gene and gene product
25. Inhibition of p300 histone acetyltransferase by viral interferon regulatory factor
26. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor
27. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
28. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
29. Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF
30. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
31. The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II
32. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
33. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV
34. The p53 pathway
35. Lytic growth of Kaposi's sarcoma-associate herpesvirus (human herpesvirus 8) in culture
36. Mutant p53: Gain-of-function oncoproteins and wild-type p53 inactivators
37. DNA damage activates p53 through a phosphorylation-acetylation cascade
38. Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins
39. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
40. Potential role of human cytomegalovirus and p53 interaction in coronary restenosis
41. Interferons and other cytokines
42. Surfing the p53 network
43. Association of human papillomavirus types 16 and 18 E6 proteins with p53
44. Regulation of apoptosis by the transforming genes of the DNA tumor virus adenovirus
45. Human herpesvirus 8 encodes an interferon regultory factor (IRF) homolog that represses IRF-1-mediated transcription