Hepatitis C virus and interferon resistance: It's more than just PKR

Hepatology

Volumn 33, Issue 6, 2001, Pages 1547-1549

  Taylor, Deborah R ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; INTERFERON; NONSTRUCTURAL PROTEIN 5A; PROTEIN KINASE; PROTEIN KINASE R; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; EDITORIAL; GENE EXPRESSION; GENE SEQUENCE; GENOTYPE; HEPATITIS C; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS GENE;

EID: 0034981634     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2001.25447     Document Type: Article

References (14)

1. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b
2. The interferon sensitivity determining region: All hepatitis C virus isolates are not the same
3. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
4. Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: Molecular mechanisms of kinase regulation
5. NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling
6. STAT activation by epidermal growth factor (EGF) and amphiregulin. Requiremant for the EGF receptor kinase but not for tyrosine phosphorylation sites or JAK1
7. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
8. Sequence analysis of the NS5A protein of European hepatitis C virus isolates and relation to interferon Sensitivity
9. Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication
10. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
11. Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase
12. Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis
13. Efficient initiation of HCV RNA replication in cell culture
14. Hepatitis C virus, the E2 envelope protein, and α-interferon resistance