Phosphorylation of nonstructural 5A protein of hepatitis C virus: HCV group-specific hyperphosphorylation

Virology

Volumn 257, Issue 1, 1999, Pages 130-137

  Hirota, Masami ^a   Satoh, Shinya ^b   Asabe, Shin Ichi ^c   Kohara, Michinori ^d   Tsukiyama Kohara, Kyoko ^d   Kato, Nobuyuki ^e   Hijikata, Makoto ^a   Shimotohno, Kunitada ^a  

^a KYOTO UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c JICHI MEDICAL UNIVERSITY   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^e NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; GENETIC TRANSFECTION; GENOTYPE; HEPATITIS C VIRUS; IMMUNOPRECIPITATION; MOLECULAR WEIGHT; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; TWO DIMENSIONAL GEL ELECTROPHORESIS;

EID: 0033602572     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1999.9658     Document Type: Article

References (21)

1. Asabe S., Tanji Y., Satoh S., Kaneko T., Kimura K., Shimotohno K. The N-terminal region of hepatitis C virus-encoded NS5A is important for NS4A-dependent phosphorylation. J. Virol. 71:1997;790-796.
2. Choo Q. L., Richman K. H., Han J. H., Berger K., Lee C., Dong C., Gallegos C., Coit D., Medina S. R., Barr P. J., Weiner A. J., Bradley D. W., Kuo G., Houghton M. Genetic organization and diversity of the hepatitis C virus. Proc. Natl. Acad. Sci. USA. 88:1991;2451-2455.
3. Eckart M. R., Selby M., Masiarz F., Lee C., Berger K., Crawford K., Kuo C., Houghton M., Choo Q. L. The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor. Biochem. Biophys. Res. Commun. 192:1993;399-406.
4. Gale M. J. Jr., Korth M. J., Tang N. M., Tan S. L., Hopkins D. A., Dever T. E., Plyak S. J., Gretch D. R., Katze M. G. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural NS5A protein. Virology. 203:1997;217-227.
5. Grakoui A., McCount D. W., Wychowski C., Feinstone S. M., Rice C. M. Characterization of the hepatitis C virus-encoded serine protease: Determination of protease-dependent polyprotein cleavage sites. J. Virol. 67:1993;2832-3843.
6. Hijikata M., Kato N., Ootsuyama Y., Nakagawa M., Shimotohno K. Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc. Natl. Acad. Sci. USA. 88:1991;5547-5551.
7. Hijikata M., Mizushima H., Akagi T., Mori S., Kakiuchi N., Kato N., Tanaka T., Kimura K., Shimotohno K. Two distinct protease activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J. Virol. 67:1993a;4665-4675.
8. Hijikata M., Mizushima H., Tanji Y., Komoda Y., Hirowatari Y., Akagi T., Kato N., Kimura K., Shimotohno K. Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus. Proc. Natl. Acad. Sci. USA. 90:1993b;10773-10777.
9. Ide Y., Tanimoto A., Sasaguri Y., Padmanabhan R. Hepatitis C virus NS5A protein is phosphorylated in vitro by a study bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-alpha catalytic subunit. Gene. 201:1997;151-158.
10. Kaneko T., Tanji Y., Satoh S., Hijikata M., Asabe S., Kimura K., Shimotohno K. Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome. Biochem. Biophys. Res. Commun. 205:1994;320-326.
11. Kato N., Hijikata M., Ootsuyama Y., Nakagawa M., Ohkoshi S., Sugimura T., Shimotohno K. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc. Natl. Acad. Sci. USA. 87:1990;9524-9528.
12. Okamoto H., Sugiyama Y., Okada S., Kurai K., Akahane Y., Sugai Y., Tanaka T., Tsuda F., Miyakawa Y. Typing hepatitis C virus by polymerase chain reaction with type-specific primers: Application to clinical surveys and tracing infectious sources. J. Gen. Virol. 73:1992;673-679.
13. Reed K., Xu J., Rice C. M. Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: Properties of the NS5A-associated kinase. J. Virol. 71:1997;7187-7197.
14. Roach P. J. Multisite and hierarchical protein phosphorylation. J. Biol. Chem. 266:1991;14139-14142.
15. Simmonds P., Alberti A., Alter H. J., Bonino F., Bradley D. W., Brechot C., Brouwer J. T., Chan S. W., Chayama K., Chen D. S. A proposed system for the nomenclature of hepatitis C viral genotypes. Hepatology. 19:1994;1321-1324.
16. Takamizawa A., Mori C., Fuke I., Manabe S., Murakami S., Fujita J., Onishi E., Andoh T., Yoshida I., Okayama H. Structure and organization of the hepatitis C virus genome isolated from human carriers. J. Virol. 65:1991;1105-1113.
17. Tanaka T., Tsukiyama-Kohara K., Yamaguchi K., Yagi S., Tanaka S., Hasegawa A., Ohta Y., Hattori N., Kohara M. Significance of specific antibody assay for genotyping of hepatitis C virus. Hepatology. 19:1994;1347-1353.
18. Tanji Y., Hijikata M., Hirowatari Y., Shimotohno K. Identification of the domain required fortrans. Gene. 145:1994a;215-219.
19. Tanji Y., Hijikata M., Hirowatari Y., Shimotohno K. Hepatitis C virus polyprotein processing: Kinetics and mutagenetic analysis of serine protease-dependent cleavage. J. Virol. 68:1994b;8418-8422.
20. Tanji Y., Kaneko T., Satoh S., Shimotohno K. Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. J. Virol. 69:1995;3980-3986.
21. Tomei L., Failla C., Santolini E., De Francesco R., La Monica N. NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J. Virol. 67:1993;4017-4026.