NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 10, 1999, Pages 5533-5538

  Tan, Seng Lai ^a   Nakao, Haruhisa ^a   He, Yupeng ^a   Vijaysri, Sangeetha ^b   Neddermann, Petra ^c   Jacobs, Bertram L ^b   Mayer, Bruce J ^d,e   Katze, Michael G ^a,f  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c IRBM   (Italy)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; NONSTRUCTURAL PROTEIN 5A; PROLINE; PROTEIN KINASE P60; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; HELA CELL; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; VIRUS PATHOGENESIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; BINDING SITES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR; GRB2 ADAPTOR PROTEIN; HELA CELLS; HEPACIVIRUS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEINS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; VACCINIA VIRUS; VIRAL NONSTRUCTURAL PROTEINS; VIRAL PROTEINS;

HEPATITIS C VIRUS; VACCINIA; VACCINIA VIRUS;

EID: 0033545996     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.10.5533     Document Type: Article

References (44)

1. Cuthbert, J. A. (1994) Clin. Microbiol. Rev. 7, 505-532.
2. Di Bisceglie, A. M. (1995) Semin. Liver Dis. 15, 64-69.
3. Lanford, R. E., Sureau, C., Jacob, J. R., White, R. & Fuerst, T. R. (1994) Virology 202, 606-614.
4. Kolykhalov, A. A., Agapov, E. V., Blight, K. J., Mihalik K., Feinstone, S. M. & Rice, C. M. (1997) Science 277, 570-574.
5. Yanagi, M., Purcell, R. H., Emerson, S. U. & Bukh, J. (1997) Proc. Natl. Acad. Sci. USA 94, 8738-8743.
6. Grakoui, A., Wychowski, C., Lin, C., Feinstone, S. M. & Rice, C. M. (1993) J. Virol. 67, 1385-1395.
7. Selby, M. J., Choo, Q. L., Berger, K., Kuo, G., Glazer, E., Eckart, M., Lee, C., Chien, D., Kuo, C. & Houghton, M. (1993) J. Gen. Virol. 74, 1103-1113.
8. van Doorn, L. J., Kleter, B., Stuyver, L., Maertens, G., Brouwer, H., Schalm, S., Heijtink, R. & Quint, W. (1994) J. Hepatol. 21, 122-129
9. Rispeter, K., Lu, M. J., Lechner, S., Zibert, A. & Roggendorf, M. (1997) J. Gen. Virol. 78, 2751-2759.
10. Lohmann, V., Koch, J. O. & Bartenschlager, R. (1996) J. Hepatol. 24, Suppl. 2, 11-19.
11. Enomoto, N., Sakuma, I., Asahina, Y., Kurosaki, M., Murakami, T., Yamamoto, C., Izumi, N., Marumo, F. & Sato, C. (1995) J. Clin. Invest. 96, 224-230.
12. Enomoto, N., Sakuma, I., Asahina, Y., Kurosaki, M., Murakami, T., Yamamoto, C. Ogura, Y., Izumi, N., Marumo, F. & Sato, C. (1996) N. Engl. J. Med. 334, 77-81.
13. Kurosaki, M., Enomoto, N., Murakami, T., Sakuma, I., Asahina, Y., Yamamoto, C., Ikeda, T., Tozuka, S., Izumi, N., Marumo, F., et al. (1997) Hepatology. 25, 750-753.
14. Chayama, K., Tsubota, A., Kobayashi, M., Okamoto, K, Hashimoto, M., Miyano, Y., Koike, H., Kobayashi, M., Koida, I., Arase, Y., et al. (1997) Hepatology 25, 745-749.
15. Gale, M., Jr., Korth, M. J., Tang, N. M., Tan, S. L., Hopkins, D. A., Dever, T. E., Polyak, S. J., Gretch, D. R. & Katze, M. G. (1997) Virology 230, 217-227.
16. Gale, M., Jr., Blakely, C. M., Kwieciszewski, B., Tan, S. L., Dossett, M., Tang, N. M., Korth, M. J., Polyak, S. J., Gretch, D. R. & Katze, M. G. (1998) Mol. Cell. Biol. 18, 5208-5218.
17. Tanimoto, A., Ide, Y., Arima, N., Sasaguri, Y. & Padmanabhan, R. (1997) Biochem. Biophys. Res. Commun. 236, 360-364.
18. Kato, N., Lan, K. H., Ono-Nita, S. K., Shiratori, Y. & Omata, M. (1997) J. Virol. 71, 8856-8859.
19. Fukuma, T., Enomoto, N., Marumo, F. & Sato, C. (1998) Hepatology 28, 1147-1153.
20. Pawson, T. (1995) Nature (London) 373, 573-580.
21. Sambrook, J., Fritsch, E. F. & Maniastis, T. (1989) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY) 2nd Ed.
22. Kibler, K. V., Shors, T., Perkins, K. B., Zeman, C. C., Banaszak, M. P., Biesterfeldt, J., Langland, J. O. & Jacobs, B. L. (1997) J. Virol. 71, 1992-2003.
23. Tanaka, M., Gupta, R. & Mayer, B. J. (1995) Mol. Cell. Biol. 15, 6829-6837.
24. Tan, S-L. & Katze, M. G. (1998) Methods Companion Methods Enzymol. 15, 207-223.
25. Mayer, B. J. & Gupta, R. (1998) Curr. Top. Microbiol. Immunol. 228, 1-22.
26. Kaneko, T., Tanji, Y., Satoh, S., Hijikata, M., Asabe, S., Kimura, K. & Shimotohno, K. (1994) Biochem. Biophys. Res. Commun. 205, 320-326.
27. Asabe, S. I., Tanji, Y., Satoh, S., Kaneko, T., Kimura, K. & Shimotohno, K. (1997) J. Virol. 71, 790-796.
28. Reed, K. E., Xu, J. & Rice, C. M. (1997) J. Virol. 71, 7187-7197.
29. Fields, S. & Song, O. (1989) Nature (London) 340, 245-246.
30. Chardin, P., Cussac, D., Maignan, S. & Ducruix, A. (1995) FEBS Lett. 369, 47-51.
31. Lin, Y. Z., Ke, X. H. & Tam, J. P. (1990) J. Biol. Chem. 265, 18884-18890.
32. Kim, H. S., Lee, Y. H., Min, D. S., Chang, J. S., Ryu, S. H., Ahn, B. Y. & Suh, P. G. (1995) Virology 214, 21-28.
33. Saksela, K., Cheng, G. & Baltimore, D. (1995) EMBO J. 14, 484-491
34. Nelson, J. W., Zhu, J., Smith, C. C., Kulka, M. & Aurelian, L. (1996) J. Biol. Chem. 271, 17021-17027.
35. Dunant, N. M., Senften, M. & Ballmer-Hofer, K. (1996) J. Virol. 70, 1323-1330.
36. Miller, C. L., Burkhardt, A. L., Lee, J. H., Stealey, B., Longnecker, R., Bolen, J. B. & Kieff, E. (1995) Immunity 2, 155-166.
37. Wei, S., Gamero, A. M, Liu, J. H., Daulton, A. A., Valkov, N. I., Trapani, J. A., Larner, A. C., Weber, M. J. & Djeu, J. Y. (1998) J. Exp. Med. 187, 1753-1765.
38. Gardner, A. M. & Johnson, G. L. (1996) J. Biol. Chem. 271, 14560-14566.
39. Karnes, W. E. Jr., Weller, S. G., Adjei, P. N., Kottke, T. J., Glenn, K. S., Gores, G. J. & Kaufmann, S. H. (1998) Gastroenterology 114, 930-939.
40. Briant, L., Robert-Hebmann, V., Sivan, V., Brunet, A., Pouyss'egur, J. & Devaux, C. (1998) J. Immunol. 160, 1875-1885.
41. Fath, I., Schweighoffer, F., Rey, I., Multon, M. C., Boiziau, J., Duchesne, M. & Tocqu'e, B. (1994) Science 264, 971-974.
42. David, M., Petricoin, E. 3rd., Benjamin, C., Pine, R., Weber, M. J. & Larner, A. C. (1995) Science 269, 1721-1723.
43. David, M., Wong, L., Flavell, R., Thompson, S. A., Wells, A., Larner, A. C. & Johnson, G. R. (1996) J. Biol. Chem. 271, 9185-9188.
44. Chung, J. K., Uchida, E., Grammer, T. C. & Blenis, J. (1997) Mol. Cell. Biol. 17, 6508-6516.