The HCMV gene products US2 and US11 target MHC class I molecules for degradation in the cytosol

Current Topics in Microbiology and Immunology

Volumn 269, Issue , 2002, Pages 37-55

  Van der Wal, F J ^a   Kikkert, M ^a   Wiertz, E ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; HLA ANTIGEN CLASS 1; RNA BINDING PROTEIN; US11 PROTEIN, VIRUS; VIRUS PROTEIN;

ANIMAL CELL; ANTIGEN DETECTION; ANTIGENICITY; APOPTOSIS; ARTICLE; COMPLEX FORMATION; CYTOMEGALOVIRUS; CYTOSOL; CYTOTOXIC T LYMPHOCYTE; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; TARGET CELL; CHEMISTRY; CYTOMEGALIC INCLUSION BODY DISEASE; ENDOPLASMIC RETICULUM; IMMUNOLOGY; METABOLISM; PROTEIN TRANSPORT; REVIEW; VIROLOGY; VIRUS REPLICATION;

CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; CYTOSOL; ENDOPLASMIC RETICULUM; HISTOCOMPATIBILITY ANTIGENS CLASS I; PROTEIN TRANSPORT; RNA-BINDING PROTEINS; VIRAL PROTEINS; VIRUS REPLICATION;

ANIMALIA; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 0035988010     PISSN: 0070217X     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-3-642-59421-2_3     Document Type: Article

References (115)

1. Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47
2. Down-regulation of the class I HLA heterodimer and beta 2-microglobulin on the surface of cells infected with cytomegalovirus
3. The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61 beta and a cytosolic, deglycosylated intermediary
4. Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains
5. Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70
6. Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway
7. Role of Cuelp in ubiquitination and degradation at the ER surface
8. De3p,/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins
9. A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae
10. The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct
11. A complex between the MHC class I homologue encoded by human cytomegalovirus and beta 2 microglobulin
12. Structure and functions of the 20S and 26S proteasomes
13. Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp1)
14. Ubiquitination is required for the retro-translocation of a short-lived luminal endoplasmic reticulum glycoprotein to the cytosol for degradation by the proteasome
15. Removal and degradation of the free MHC class II beta chain in the endoplasmic reticulum requires proteasomes and is accelerated by BFA
16. Cytosolic deglycosylation process of newly synthesized glycoproteins generates oligomannosides possessing one GlcNAc residue at the reducing end
17. Setting the standards: Quality control in the secretory pathway
18. The protein disulphide-isomerase family: Unravelling a string of folds
19. The degradation of apolipoprotein B 100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70
20. A regulatory link between ER-associated protein degradation and the unfolded-protein response
21. A viral inhibitor of peptide transporters for antigen presentation
22. Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors
23. In vivo action of the HRD ubiquitin ligase complex: Mechanisms of endoplasmic reticulum quality control and sterol regulation
24. Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p
25. Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner
26. Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2
27. Protein disulfide isomerase and assisted protein folding
28. Export of a cysteine-free misfolded secretory protein from the endoplasmic reticulum for degradation requires interaction with protein disulfide isomerase
29. The protein translocation channel mediates glycopeptide export across the endoplasmic reticulum membrane
30. Role of lipid synthesis, chaperone proteins and proteasomes in the assembly and secretion of apoprotein B-containing lipoproteins from cultured liver cells
31. Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70
32. Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase
33. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein
34. Generation, translocation, and presentation of MHC class I-restricted peptides
35. Immune evasion by cytomegalovirus-survival strategies of a highly adapted opportunist
36. The ubiquitin system
37. The human cytomegalovirus gene product US6 inhibits ATP binding by TAP
38. Herpes simplex virus turns off the TAP to evade host immunity
39. ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway
40. TMbase - A database of membrane spanning protein segments
41. Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome
42. The alpha chain of the T cell antigen receptor is degraded in the cytosol
43. Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome
44. Multiple proteolytic systems, including the proteasome, contribute to CFTR processing
45. The translocon: A dynamic gateway at the ER membrane
46. Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains
47. Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains
48. Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol
49. The sizes of peptides generated from protein by mammalian 26 and 20S proteasomes. Implications for understanding the degradative mechanism and antigen presentation
50. Protein degradation in the endoplasmic reticulum
51. Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel
52. ER quality control: The cytoplasmic connection
53. Aggresomes and Russell bodies - Symptoms of cellular indigestion?
54. Structural and functional dissection of human cytomegalovirus US3 in binding major histocompatibility complex class I molecules
55. The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation
56. Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1
57. Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1
58. Intracellular disposal of incompletely folded human alpha 1-antitrypsin involves release from calnexin and post-translational trimming of asparagine-linked oligosaccharides
59. Oligosaccharide modification in the early secretory pathway directs the selection of a misfolded glycoprotein for degradation by the proteasome
60. The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains
61. BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane
62. Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein
63. Assembly of ER-associated protein degradation in vitro: Dependence on cytosol, calnexin, and ATP
64. The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
65. Mammalian Sec61 is associated with Sec62 and Sec63
66. Protein disulfide isomerase: The multifunctional redox chaperone of the endoplasmic reticulum
67. Functional differences in yeast protein disulfide isomerases
68. ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin
69. Interaction of the thiol-dependent reductase ERp57 with nascent glycoproteins
70. Identification of proteins that interact with mammalian peptide: N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation
71. Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation
72. Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin
73. Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation
74. Re-entering the translocon from the lumenal side of the endoplasmic reticulum. Studies on mutated carboxypeptidase yscY species
75. Viral strategies of immune evasion
76. Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity
77. The major substrates for TAP in vivo are derived from newly synthesized proteins
78. A cytomegalovirus glycoprotein re-routes MHC class I complexes to lysosomes for degradation
79. Degradation of cell proteins and the generation of MHC class I-presented peptides
80. Similar processes mediate glycopeptide export from the endoplasmic reticulum in mammalian cells and Saccharomyces cerevisiae
81. Distinct processes mediate glycoprotein and glycopeptide export from the endoplasmic reticulum in Saccharomyces cerevisiae
82. CD4 glycoprotein degradation induced by human immunodeficiency virus type I Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway
83. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
84. Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11
85. Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol
86. The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate
87. Molecular characterization of a novel mammalian Dna J-like Sec63p homolog
88. The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products
89. PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase
90. Rad23 provides a link between the Png1 deglycosylating enzyme and the 26S proteasome in yeast
91. Identification of peptide:N-glycanase activity in mammalian-derived cultured cells
92. Purification and enzymatic properties of peptide:N-glycanase from C3H mouse-derived L-929 fibroblast cells. Possible widespread occurrence of post-translational remodification of proteins by N-deglycosylation
93. Glycosamidases
94. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s)
95. Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP
96. Viral subversion of the immune system
97. Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential
98. Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomes
99. The 26S proteasome: A molecular machine designed for controlled proteolysis
100. Degradation of CFTR by the ubiquitin-proteasome pathway
101. Cytomegaloviruses use multiple mechanisms to elude the host immune response
102. The human cytomegalovirus USI I gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
103. Viruses use stealth technology to escape from the host immune system
104. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
105. HRD gene dependence of endoplasmic reticulum-associated degradation
106. Distinct domains within yeast Sec61p involved in post-translational translocation and protein dislocation
107. Degradation of distinct assembly forms of immunoglobulin M occurs in multiple sites in permeabilized B cells
108. Down-regulation of the surface expression of class I MHC antigens by human cytomegalovirus
109. Rapid degradation of the heavy chain of class I major histocompatibility complex antigens in the endoplasmic reticulum of human cytomegalovirus-infected cells
110. Not such a dismal science: The economics of protein synthesis, folding, degradation and antigen processing
111. Cytosolic degradation of T-cell receptor alpha chains by the proteasome
112. The role of multiubiquitination in dislocation and degradation of the alpha subunit of the T cell antigen receptor
113. Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast
114. The engagement of Sec61p in the ER dislocation process
115. The luminal part of the murine cytomegalovirus glycoprotein gp40 catalyzes the retention of MHC class I molecules