Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast

Molecular Biology of the Cell

Volumn 12, Issue 5, 2001, Pages 1303-1314

  Zhang, Y ^a   Nijbroek, G ^a   Sullivan, M L ^a   McCracken, A A ^a   Watkins, S C ^a   Michaelis, S ^a   Brodsky, J L ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CALNEXIN; CHAPERONE; HEAT SHOCK PROTEIN 70; TRANSMEMBRANE CONDUCTANCE REGULATOR; UBIQUITIN CONJUGATING ENZYME;

ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN STABILITY; SACCHAROMYCES CEREVISIAE; SPECIES DIFFERENCE; STRAIN DIFFERENCE; YEAST;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0034757165     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.5.1303     Document Type: Article

References (93)

1. The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61β and a cytosolic, deglycosylated intermediary
2. Expression of the 180-kD ribosome receptor induces membrane proliferation and increased secretory activity in yeast
3. Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo
4. Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperones Hsc70
5. Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway
6. Role of Cue1p in ubiquitination and degradation at the ER surface
7. Ubiquitin and the control of protein fate in the secretory and endocytic compartments
8. Molecular evolution of the HSP70 multigene family
9. Der3p-Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins
10. Mutations in the cytosolic DnaJ homologue YDJ1 delay and compromise the efficient translation of heterologous proteins in yeast
11. ER protein quality control and proteasome-mediated protein degradation
12. A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteo-liposome
13. The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct
14. Cystic fibrosis transmembrane conductance regulator has an altered structure when its maturation is inhibited
15. Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor
16. Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis
17. Multifunctional yeast high-copy-number shuttle vectors
18. The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane
19. Regulation of Hsp70 function by a eukaryotic DnaJ homolog
20. Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive
21. Degradation of a short-lived glycoprotein from the lumen of the endoplasmic reticulum: The role of N-linked glycans and the unfolded protein response
22. Degradation of human thyroperoxidase in the endoplasmic reticulum involves two different pathways depending on the folding state of the protein
23. The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70
24. Isolation of intracellular membranes by means of sodium carbonate treatment: Application to endoplasmic reticuium
25. Rapid degradation of an unassembled immunoglobulin light chain is mediated by a serine protease and occurs in a pre-Golgi compartment
26. Endoplasmic reticulum degradation requires lumen to cytosol signaling: Transmembrane control of Hrdlp by Hrd3p
27. Mammalian BiP
28. Export of a cysteine-free misfolded secretory protein from the endoplasmic reticulum for degradation requires interaction with protein disulfide isomerase
29. BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocation pore before and early in translocation
30. Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase
31. Role of 26S proteasome and HIRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein
32. PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins
33. Proteinase yscE., the yeast proteasome/multicatalytic-multifunctional proteinase: Mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival
34. Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system
35. ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway
36. A pathway for targeting soluble misfolded proteins to the yeast vacuole
37. Functional expression of the cystic fibrosis transmembrane conductance regulator in yeast
38. Transformation of intact yeast cells treated with alkali cations
39. Multiple proteolytic systems, including the proteasome, contribute to CFTR processing
40. Partial restoration of cAMP-stimulated CFTR chloride channel activity in DeltaF508 cells by deoxyspergualin
41. Aggresomes: A cellular response to misfolded proteins
42. Tackling the protease problem in Saccharomyces cerevisiae
43. Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway
44. Molecular chaperones involved in protein degradation in the endoplasmic reticulum: Quantitative interaction of the heat shock cognate protein BiP with partially folded immunoglobulin light chains that are degraded in the endoplasmic reticulum
45. Association between calnexin and a secretion-incompetent variant of human alpha 1-antitrypsin
46. Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae
47. Ste6p mutants defective in exit from the endoplasmic reticulum (ER) reveal aspects of an ER quality control pathway in Saccharomyces cerevisiae
48. Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome
49. Conformational maturation of CFTR but not its mutant counterpart (ΔF508) occurs in the endoplasmic reticulum and requires ATP
50. Role of the proteasome in membrane extraction of a short-lived ER transmembrane protein
51. Assembly of ER-associated protein degradation in vitro: Dependence on cytosol, calnexin, and ATP
52. Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis
53. The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis
54. The Hsp70 family - An overview
55. Degradation of HMG-CoA reductase in vitro. Cleavage in the membrane domain by a membrane-bound cysteine protease
56. A mutation affecting signal peptidase inhibits degradation of an abnormal membrane protein in Saccharomyces cerevisiae
57. Inhibition of endoplasmic reticulum (ER)-to-Golgi transport induces relocalization of binding protein (BiP) within the ER to form the BiP bodies
58. The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control
59. Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticulum (ER) membrane protein with sequence similarity to calnexin and calreticulin and functions as a constituent of the ER quality control apparatus
60. The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome-nascent chain complex
61. Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation
62. Participation of the endoplasmic reticulum chaperones calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator
63. Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation
64. Reentering the translocon from the lumenal side of the endoplasmic reticulum. Studies on mutated carboxypeptidase yscY species
65. Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome
66. Retrograde protein translocation: Eradication of secretory proteins in health and disease
67. Fluorescence microscopy methods for yeast
68. Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity
69. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
70. Surfing the Sec61 channel: Bidirectional protein translocation across the ER membrane
71. Sodium 4-phenylbutyrate downregulates Hsc70: Implications for intracellular trafficking of ΔF508-CFTR
72. Hsp70 family molecular chaperones and mutant insulin receptor: Differential binding specificities of BiP and Hsp70/Hsc70 determines accumulation or degradation of insulin receptor
73. In vivo iodination of a misfolded proinsulin reveals co-localized signals for BiP binding and for degradation in the ER
74. Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum
75. The molecular chaperone Hsc70 assists the in vitro folding of the N-terminal nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator
76. Accumulation of misfolded protein aggregates leads to the formation of russell body-like dilated endoplasmic reticulum in yeast
77. Cystic fibrosis mutations lead to carboxyl-terminal fragments that highlight an early biogenesis step of the cystic fibrosis transmembrane conductance regulator
78. The 26S proteasome: A molecular machine designed for controlled proteolysis
79. Degradation of CFTR by the ubiquitin-proteasome pathway
80. Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate
81. Complex interactions among members of an essential subfamily of hsp70 genes in Saccharomyces cerevisiae
82. Seco61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
83. Dynamic association of proteasomal machinery with the centrosome
84. Endoplasmic reticulum degradation of a subunit of the asialoglycoprotein receptor in vitro. Vesicular transport from endoplasmic reticulum is unnecessary
85. Degradation of T-cell receptor chains in the endoplasmic reticulum is inhibited by inhibitors of cysteine proteases
86. HRD gene dependence of endoplasmic reticulum associated degradation
87. Increased amounts of HMG-CoA reductase induce "karmellae", a proliferation of stacked membrane pairs surrounding the yeast nucleus
88. Evidence that endoplasmic reticulum (ER)-associated degradation of cystic fibrosis transmembrane conductance regulator is linked to retrograde translocation from the ER membrane
89. The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment
90. Cytosolic degradation of T-cell receptor alpha chains by the proteasome
91. CFTR expression and ER associated degradation in yeast
92. Regulated co-translational ubiquitination of Apolipoprotein B100