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Volumn 15, Issue , 1999, Pages 799-842

The translocon: A dynamic gateway at the ER membrane

Author keywords

Cotranslational; Endoplasmic reticulum; Protein integration; Protein translocation; Sec61

Indexed keywords

MEMBRANE PROTEIN; TRANSLOCON;

EID: 0033281074     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.15.1.799     Document Type: Review
Times cited : (508)

References (196)
  • 5
    • 0030800343 scopus 로고    scopus 로고
    • Cotranslational degradation of apolipoprotein B100 by the proteasome is prevented by microsomal triglyceride transfer protein. Synchronized translation studies on HepG2 cells treated with an inhibitor of microsomal triglyceride transfer protein
    • (1997) J. Biol. Chem. , vol.272 , pp. 20435-20442
    • Benoist, F.1    Grand-Perret, T.2
  • 7
    • 0016753216 scopus 로고
    • Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma
    • (1975) J. Cell Biol. , vol.67 , pp. 835-851
    • Blobel, G.1    Dobberstein, B.2
  • 10
    • 0029894267 scopus 로고    scopus 로고
    • Biogenesis of polytopic membrane proteins: Membrane segments assemble within translocation channels prior to membrane integration
    • (1996) Cell , vol.85 , pp. 379-389
    • Borel, A.C.1    Simon, S.M.2
  • 12
    • 85047669331 scopus 로고    scopus 로고
    • Post-translational protein translocation: Not all hsc70s are created equal
    • (1996) TIBS , vol.21 , pp. 122-126
    • Brodsky, J.L.1
  • 20
    • 0026536874 scopus 로고
    • Pause transfer: A topogenic sequence in apolipoprotein B mediates stopping and restarting of translocation
    • (1992) Cell , vol.68 , pp. 9-21
    • Chuck, S.L.1    Lingappa, V.R.2
  • 24
    • 0030930513 scopus 로고    scopus 로고
    • The lumenal domain of Sec63p stimulates the ATPase activity of BiP and mediates BiP recruitment to the translocon in Saccharomyces cerevisiae
    • (1997) J. Cell Biol. , vol.137 , pp. 1483-1493
    • Corsi, A.K.1    Schekman, R.2
  • 26
    • 0027162564 scopus 로고
    • The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocation
    • (1993) Cell , vol.73 , pp. 1101-1115
    • Crowley, K.1    Reinhart, G.D.2    Johnson, A.J.3
  • 28
    • 0026022577 scopus 로고
    • Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules
    • (1991) J. Cell Biol. , vol.112 , pp. 1099-1115
    • Degen, E.1    Williams, D.B.2
  • 29
    • 0029561894 scopus 로고
    • Transmembrane orientation of signal-anchor proteins is affected by the folding state but not the size of the N-terminal domain
    • (1995) EMBO J. , vol.14 , pp. 6311-6317
    • Denzer, A.J.1    Nabholz, C.E.2    Spiess, M.3
  • 30
  • 36
    • 0031984440 scopus 로고    scopus 로고
    • Bacterial preprotein translocase: Mechanism and conformational dynamics of a processive enzyme
    • (1998) Mol. Microbiol. , vol.27 , pp. 511-518
    • Economou, A.1
  • 37
    • 0028064967 scopus 로고
    • SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion
    • (1994) Cell , vol.78 , pp. 835-843
    • Economou, A.1    Wickner, W.2
  • 38
    • 0019464222 scopus 로고
    • The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis
    • (1981) Cell , vol.23 , pp. 411-422
    • Engelman, D.M.1    Steitz, T.A.2
  • 40
    • 0032478623 scopus 로고    scopus 로고
    • Connexin membrane protein biosynthesis is influenced by polypeptide positioning within the translocon and signal peptidase access
    • (1998) J. Biol. Chem. , vol.273 , pp. 7856-7864
    • Falk, M.M.1    Gilula, N.B.2
  • 46
    • 0028834046 scopus 로고
    • Can Hsp70 proteins act as force-generating motors?
    • (1995) Cell , vol.80 , pp. 11-14
    • Glick, B.S.1
  • 49
    • 0027424601 scopus 로고
    • Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane
    • (1993) Cell , vol.75 , pp. 615-630
    • Görlich, D.1    Rapoport, T.A.2
  • 54
    • 0032549767 scopus 로고    scopus 로고
    • BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation
    • (1998) Cell , vol.92 , pp. 747-758
    • Hamman, B.D.1    Hendershot, L.M.2    Johnson, A.E.3
  • 61
    • 0029924441 scopus 로고    scopus 로고
    • Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol
    • (1996) Cell , vol.85 , pp. 217-228
    • Hegde, R.S.1    Lingappa, V.R.2
  • 62
    • 0030782178 scopus 로고    scopus 로고
    • Membrane protein biogenesis: Regulated complexity at the endoplasmic reticulum
    • (1997) Cell , vol.91 , pp. 575-582
    • Hegde, R.S.1    Lingappa, V.R.2
  • 72
    • 0027393014 scopus 로고
    • The SecA and SecY subunits of translocase are the nearest neighbors of a translocating preprotein, shielding it from phospholipids
    • (1993) EMBO J. , vol.12 , pp. 255-263
    • Joly, J.C.1    Wickner, W.2
  • 74
  • 79
  • 80
    • 0032055475 scopus 로고    scopus 로고
    • Membrane integration of Sec61α: A core component of the endoplasmic reticulum translocation complex
    • (1998) Biochem. J. , vol.331 , pp. 161-167
    • Knight, B.C.1    High, S.2
  • 82
    • 0030949874 scopus 로고    scopus 로고
    • ER quality control: The cytoplasmic connection
    • (1997) Cell , vol.88 , pp. 427-430
    • Kopito, R.R.1
  • 84
    • 0024425706 scopus 로고
    • Protein translocation across the endoplasmic reticulum membrane: Identification by photocross-linking of a 39 kD integral membrane glycoprotein as part of a putative translocation tunnel
    • (1989) J. Cell Biol. , vol.109 , pp. 2033-2043
    • Krieg, U.C.1    Johnson, A.E.2    Walter, P.3
  • 85
  • 88
    • 0030334864 scopus 로고    scopus 로고
    • Membrane proteins which exhibit multiple topological orientations
    • (1996) Essays Biochem , vol.31 , pp. 49-60
    • Levy, D.1
  • 89
    • 0031471055 scopus 로고    scopus 로고
    • Both lumenal and cytosolic gating of the aqueous ER translocon pore is regulated from inside the ribosome during membrane protein integration
    • (1997) Cell , vol.90 , pp. 31-41
    • Liao, S.1    Lin, J.2    Do, H.3    Johnson, A.E.4
  • 90
    • 0025019705 scopus 로고
    • The ATPase activity of SecA is regulated by acidic phospholipids, SecY, and the leader and mature domains of precursor proteins
    • (1990) Cell , vol.60 , pp. 271-280
    • Lill, R.1    Dowhan, W.2    Wickner, W.3
  • 91
    • 0028900576 scopus 로고
    • A novel integration signal that is composed of two transmembrane segments is required to integrate the neurospora plasma membrane H+-ATPase into microsomes
    • (1995) J. Biol. Chem. , vol.270 , pp. 6935-6941
    • Lin, J.1    Addison, R.2
  • 97
    • 0030970268 scopus 로고    scopus 로고
    • Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP
    • (1997) Cell , vol.88 , pp. 85-96
    • Lyman, S.K.1    Schekman, R.2
  • 98
    • 0021738720 scopus 로고
    • Segregation of the polypeptide translocation apparatus to regions of the endoplasmic reticulum containing ribophorins and ribosomes. II. Rat liver microsomal subfractions contain equimolar amounts of ribophorins and ribosomes
    • (1984) J. Cell Biol. , vol.99 , pp. 2254-2259
    • Marcantonio, E.E.1    Amar-Costesec, A.2    Kreibich, G.3
  • 104
    • 85047669202 scopus 로고    scopus 로고
    • The targeting and assembly of peroxisomal proteins: Some old rules do not apply
    • (1996) TIBS , vol.21 , pp. 54-58
    • McNew, J.A.1    Goodman, J.M.2
  • 115
    • 0027936633 scopus 로고
    • Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane
    • (1994) EMBO J. , vol.13 , pp. 3973-3982
    • Mothes, W.1    Prehn, S.2    Rapoport, T.A.3
  • 121
    • 0025019704 scopus 로고
    • Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes
    • (1990) Cell , vol.60 , pp. 259-269
    • Nicchitta, C.V.1    Blobel, G.2
  • 122
    • 0027238583 scopus 로고
    • Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation
    • (1993) Cell , vol.73 , pp. 989-998
    • Nicchitta, C.V.1    Blobel, G.2
  • 124
    • 0031417386 scopus 로고    scopus 로고
    • Regulation of the ribosome-membrane junction at early stages of presecretory protein translocation in the mammalian endoplasmic reticulum
    • (1997) J. Cell Biol. , vol.139 , pp. 1697-1708
    • Nicchitta, C.V.1    Zheng, T.2
  • 125
    • 0027417476 scopus 로고
    • Determination of the distance between the oligosaccharyltransferase active site and the endoplasmic reticulum membrane
    • (1993) J. Biol. Chem. , vol.268 , pp. 5798-5801
    • Nilsson, I.1    Von Heijne, G.2
  • 127
    • 0027967458 scopus 로고
    • A Sec62p-related component of the secretory protein translocon from Drosophila displays developmentally complex behavior
    • (1994) EMBO J. , vol.13 , pp. 5253-5261
    • Noel, P.J.1    Cartwright, I.L.2
  • 135
    • 0030789680 scopus 로고    scopus 로고
    • Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation
    • (1997) EMBO J. , vol.16 , pp. 4540-4548
    • Pilon, M.1    Schekman, R.2    Römisch, K.3
  • 140
    • 0029097359 scopus 로고
    • Reciprocal stimulation of GTP hydrolysis by two directly inter-acting GTPases
    • (1995) Science , vol.269 , pp. 1422-1424
    • Powers, T.1    Walter, P.2
  • 141
    • 0030832397 scopus 로고    scopus 로고
    • Co-translational protein targeting catalyzed by the Escherichia coli signal recognition particle and its receptor
    • (1997) EMBO J. , vol.16 , pp. 4880-4886
    • Powers, T.1    Walter, P.2
  • 143
    • 0031933791 scopus 로고    scopus 로고
    • Signal recognition particle-dependent targeting of ribosomes to the rough endoplasmic reticulum in the absence and presence of the nascent polypeptide-associated complex
    • (1998) Mol. Biol. Cell , vol.8 , pp. 117-130
    • Raden, D.1    Gilmore, R.2
  • 144
    • 0030678106 scopus 로고    scopus 로고
    • Empty site forms of the SRP54 and SRα GTPases mediate targeting of ribosome-nascent chain complexes to the endoplasmic reticulum
    • (1997) Cell , vol.89 , pp. 703-713
    • Rapiejko, P.J.1    Gilmore, R.2
  • 158
    • 0027519416 scopus 로고
    • Amino-terminal assembly of human P-glycoprotein at the endoplasmic reticulum is directed by cooperative actions of two internal sequences
    • (1993) J. Biol. Chem. , vol.268 , pp. 23552-23561
    • Skach, W.R.1    Lingappa, V.R.2
  • 160
    • 0027327659 scopus 로고
    • A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum
    • (1993) Nature , vol.365 , pp. 176-179
    • Sommer, T.1    Jentsch, S.2
  • 161
  • 162
    • 0029149453 scopus 로고
    • Heads or tails - What determines the orientation of proteins in the membrane
    • (1995) FEBS Lett. , vol.369 , pp. 76-79
    • Spiess, M.1
  • 165
    • 0031045007 scopus 로고    scopus 로고
    • Interactions between newly synthesized glycoproteins, calnexin and a network of resident chaperones in the endoplasmic reticulum
    • (1997) J. Cell Biol. , vol.136 , pp. 555-565
    • Tatu, U.1    Helenius, A.2
  • 175
    • 0030919649 scopus 로고    scopus 로고
    • Multiple determinants direct the orientation of signalanchor proteins: The topogenic role of the hydrophobic signal domain
    • (1997) J. Cell Biol. , vol.137 , pp. 555-562
    • Wahlberg, J.M.1    Spiess, M.2
  • 179
    • 0023782388 scopus 로고
    • Insertion of a multispanning membrane protein occurs sequentially and requires only one signal sequence
    • (1988) Cell , vol.55 , pp. 61-70
    • Wessels, H.P.1    Spiess, M.2
  • 192
    • 0029116124 scopus 로고
    • Involvement of cytoplasmic factors regulating the membrane orientation of p-glycoprotein sequences
    • (1995) Biochemistry , vol.34 , pp. 9159-9165
    • Zhang, J.-T.1    Ling, V.2


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