Identification of β-secretase-like activity using a mass spectrometry- based assay system

Nature Biotechnology

Volumn 18, Issue 1, 2000, Pages 66-70

  Grüninger Leitch, Fiona ^a   Berndt, Peter ^a   Langen, Hanno ^a   Nelboeck, Peter ^a   Döbeli, Heinz ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Alzheimer disease; Lysosomal proteases; Mass spectrometry

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; CATHEPSIN D; CATHEPSIN E; M PROTEIN; PEPSTATIN; PROTEINASE;

ARTICLE; ASTROCYTOMA CELL; CELL FREE SYSTEM; CERAMICS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; KIDNEY CELL; LYSOSOME; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CATHEPSIN D; CATHEPSIN E; CELL EXTRACTS; CELL LINE; CERAMICS; ENDOPEPTIDASES; HUMANS; METALLOENDOPEPTIDASES; MICE; MICROSPHERES; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUTATION; PEPSTATINS; PEPTIDE FRAGMENTS; RATS; RECOMBINANT FUSION PROTEINS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY; SWEDEN; TRANSFECTION;

EID: 0141834421     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/71944     Document Type: Article

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