Analysis of interaction sites in homo- and heteromeric complexes containing Bcl-2 family members and the cellular prion protein

Molecular Brain Research

Volumn 37, Issue 1-2, 1996, Pages 249-258

  Kurschner, Cornelia ^a   Morgan, James I ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Al; Bax; Bcl 2; Neurodegeneration; Structural analysis; Two hybrid system

Indexed keywords

PROTEIN; PROTEIN BAX; PROTEIN BCL 2;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; EARLY RESPONSE GENE; IMMUNOPRECIPITATION; NONHUMAN; PRION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; YEAST;

BCL-2-ASSOCIATED X PROTEIN; HYBRID CELLS; PRECIPITIN TESTS; PRIONS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0029932071     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-328x(95)00323-k     Document Type: Article

References (35)

1. Alnemri, E.S., Robertson, N.M., Fernandes, T.F., Croce, C.M. and Litwack, G., Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells, Proc. Natl. Acad. Sci. USA, 89 (1992) 7295-7299.
2. Bakhshi, A., Jensen, J.P., Goldman, P., Wright, J.J., McBride, O.W., Epstein, A.L. and Korsmeyer, S.J., Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering on JH on chromosome 14 and near a transcriptional unit on 18, Cell, 41 (1985) 899-906.
3. Batistatou, A., Merry, D.E., Korsmeyer, S.J. and Greene, L.A., Bcl-2 affects survival but not neuronal differentiation of PC12 cells, J. Neurosci., 13 (1993) 4422-4428.
4. Boise, L.H., Gonzales-Garcia, M., Postema, C.E., Ding, L., Lindsten, T., Turka, L.A., Mao, X., Nunes, G. and Thompson, C.B., bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death, Cell, 74 (1993) 597-608.
5. Borner, C., Martinou, I., Mattmann, C., Irmler, M., Schaerer, E., Martinou, J.-C. and Tschopp, J., The protein bcl-2a does not require membrane attachment, but two conserved domains to suppress apoptosis, J. Cell Biol., 126 (1994) 1059-1068.
6. Boyd, J.M., Malstrom, S., Subramanian, T., Venkatesh, L.K., Schaeper, U., Elangovan, B., D'Sa-Eipper, C. and Chinnadurai, G., Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins, Cell, 79 (1994) 341-351.
7. Cleary, M.L. and Sklar, J., Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint cluster region near a transcriptionally active locus on chromosome 18, Proc. Natl. Acad. Sci. USA, 82 (1985) 7439-7443.
8. Collinge, J., Whittington, M.A., Sidle, K.C.L., Smith, C.J., Palmer, M.S., Clarke, A.R. and Jefferys, J.G.R., Prion protein is necessary for normal synaptic function, Nature, 370 (1994) 295-297.
9. Dalton, S. and Treisman, R., Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element, Cell, 68 (1992) 597-612.
10. Dubois-Dauphin, M., Frankowski, H., Tsujimoto, Y., Huarte, J. and Martinou, J.C., Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death, Proc. Natl. Acad. Sci. USA, 91 (1994) 3309-3313.
11. Ebina, Y., Takahara, Y., Kishi, F., Nakazawa, A. and Parker, C.S., LexA protein is a repressor of the colicin EI gene, J. Biol. Chem., 258 (1983) 13258-13261.
12. Fernandez-Sarabia, M.J. and Bischoff, J.R., Bcl-2 associates with the ras-related protein R-ras p23, Nature, 366 (1993) 274-275.
13. Garcia, I., Martinou, I., Tsujimoto, Y. and Martinou, J.-C., Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene, Science, 258 (1992) 302-304.
14. Guarente, L., Yocum, R.R. and Gifford, P., A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site. Proc. Natl. Acad. Sci. USA, 79 (1982) 7410-7414.
15. Guthrie, C. and Fink, G.R. (Eds.) Guide to Yeast Genetics and Molecular Biology, Methods in Enzymology, Vol. 194, Academic Press, San Diego, CA, 1991.
16. Hanada, M., Aimé-Sempé, C., Sato, T. and Reed, J.C., Structure-function analysis of Bcl-2 protein, J. Biol. Chem., 270 (1995) 11962-11969.
17. Hockenbery, D.M., Oltvai, Z.N., Yin, X.-M., Milliman, C.L. and Korsmeyer, S.J., Bcl-2 functions in an antioxidant pathway to prevent apoptosis, Cell, 75 (1993) 241-251.
18. Kurschner, C. and Morgan, J.I., The maf proto-oncogene stimulates transcription from multiple sites in a promoter that directs Purkinje neuron-specific gene expression, Mol. Cell. Biol., 15 (1995) 246-254.
19. Kurschner, C. and Morgan, J.I., The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system, Mol. Brain Res., 30 (1995) 165-168.
20. Lin, E.Y., Orlofsky, A., Berger, M.S. and Prystowsky, M.B., Characterization of Al, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2, J. Immunol., 151 (1993) 1979-1988.
21. Mah, S.P., Zhong, L.T., Liu, Y., Roghani, A., Edwards, R.H. and Bredesen, D.E., The protooncogene bcl-2 inhibits apoptosis in PC12 cells, J. Neurochem., 60 (1993) 1183-1186.
22. Nguyen, M., Branton, P.E., Walton, P.A., Oltvai, Z.N., Korsmeyer, S.J. and Shore, G.C., Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus, J. Biol. Chem., 269 (1994) 16521-16524.
23. Oltvai, Z.N., Milliman, C.L. and Korsmeyer, S.J., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death, Cell, 74 (1993) 609-619.
24. Sato, T., Hanada, M., Bodrug, S., Irie, S., Iwama, N., Boise, L.H., Thompson, C., Golemis, E., Fong, L., Wang, H.-G. and Reed, J.C., Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system, Proc. Natl. Acad. Sci. USA, 91 (1994) 9238-9242.
25. Takayama, S., Sato, T., Krajewski, S., Kochel, K., Irie, S., Millan, J.A. and Reed, J.C., Cloning and functional analysis of BAG-1: a novel Bcl-2 binding protein with anti-cell death activity, Cell, 80 (1995) 279-284.
26. Tanaka, S., Saito, K. and Reed, J.C., Structure-function analysis of the Bcl-2 oncoprotein, J. Biol. Chem., 268 (1993) 10920-10926.
27. Telling, G.C., Scott, M., Mastrianni, J., Gabizon, R., Torchia, M., Cohen, F.E., DeArnold, S.J. and Prusiner, S.B., Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein, Cell, 83 (1995) 79-90.
28. Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E. and Croce, C.M., The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining, Science, 229 (1985) 1390-1393.
29. Tsujimoto, Y. and Croce, C.M., Analysis of the structure, transcripts and protein products of bcl-2, the gene involved in human follicular lymphoma, Proc. Natl. Acad. Sci. USA, 83 (1986) 5214-5218.
30. Wang, H.-G., Miyashita, T., Takayama, S., Sato, T., Torigoe, T., Krajewski, S., Tanaka, S., Hovey III, L., Troppmair, J., Rapp, U.R. and Reed, J.C., Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase, Oncogene, 9 (1994) 2751-2756.
31. Weissmann, C., Molecular biology of prion diseases, Trends Cell Biol., 4 (1994) 10-14.
32. Williams, G.T. and Smith, C.A., Molecular regulation of apoptosis: genetic controls of cell death, Cell, 74 (1993) 777-779.
33. L and Bcl-2, displaces Bax and promotes cell death, Cell, 80 (1995) 285-291.
34. Yin, X.-M., Oltvai, Z.N. and Korsmeyer, S.J., BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax, Nature, 369 (1994) 321-323.
35. Zhong, L.-T., Sarafian, T., Kane, D.J., Charles, A.C., Mah, S.P., Edwards, R.H. and Bredesen, D.E., bcl-2 inhibits death of central neural cells induced by multiple agents, Proc. Natl. Acad. Sci. USA, 90 (1993) 4533-4537.