Apolipoprotein E includes a binding site which is recognized by several amyloidogenic polypeptides

Biochemical Journal

Volumn 349, Issue 1, 2000, Pages 77-84

  Baumann, Marc H ^c   Kallijärvi, Jukka ^c   Lankinen, Hilkka ^c   Soto, Claudio ^a,b   Haltia, Matti ^c  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b Serono International SA   (Switzerland)

^c NONE

Author keywords

Alzheimer's disease; Amyloidosis of the Finnish type; Pathological chaperone; Prion disease

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; GELSOLIN; PRION PROTEIN;

ALZHEIMER DISEASE; ARTICLE; BINDING SITE; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL;

AMINO ACID MOTIFS; AMYLOID BETA-PROTEIN; AMYLOIDOSIS; APOLIPOPROTEINS E; BINDING SITES; BINDING, COMPETITIVE; BLOTTING, WESTERN; CIRCULAR DICHROISM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; KINETICS; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE; SURFACE PLASMON RESONANCE;

EID: 0242567349     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3490077     Document Type: Article

References (57)

1. 1 Ghiso, J., Wisniewski, T. and Frangione, B. (1994) Unifying features of systemic and cerebral amyloidosis. Mol. Neurobiol. 8, 49-64
2. 2 Prusiner, S. B., McKinley, M. P., Bowman, K. A., Bolton, D. C., Bendheim, P. E., Groth, D. F. and Glenner, G. G. (1983) Scrapie prions aggregate to form amyloid-like birefringence rods. Cell 35, 349-358
3. 3 Tagliavini, F., Prelli, F., Verga, L., Giaccone, G., Sarma, R., Gorevic, P., Ghetti, B., Passerini, F., Ghibaudi, E., Forloni, G., Salmona, M., Bugiani, O. and Frangione, B. (1993) Synthetic peptides homologous to priori protein residues 106-147 form amyloid-like fibrils in vitro. Proc. Natl. Acad. Sci. U.S.A. 90, 9678-9682
4. 4 Glenner, G. C. and Wong, C. W. (1984) Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 120, 885-890
5. 5 Hardy, J. (1997) Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 20, 154-159
6. 6 Levy-Lahad, E. and Bird, T. (1996) Genetic factors in Alzheimer's disease: a review of recent advances. Ann. Neurol. 40, 829-840
7. 7 Goate, A., Chartier-Harlin, M. C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L. et al. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature (London) 349, 704-706
8. 8 Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K. et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature (London) 375, 754-760
9. 9 Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C. E., Jondro, P. D., Schmidt, S. D., Wang, K. et al. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977
10. 10 Norwich, A. and Weissman, J. S. (1997) Deadly conformations-protein misfolding in prion disease. Cell 89, 499-510
11. 11 Kiuru, S. (1998) Gelsolin-related familial amyloidosis, Finnish type (FAF), and its variants found worldwide Amyloid Int. J. Exp. Clin. Invest. 5, 55-66
12. 12 Weeds, A. G., Gooch, J., McLaughlin, P. and Maury, C. P. J. (1993) Variant plasma gelsolin responsible for familial amyloidosis (Finnish type) has defective actin severing activity. FEBS Lett. 335, 119-123
13. 13 McLaughlin, P. J., Gooch, J. T., Mannherz, H.-G. and Weeds, A. G. (1993) Structure of gelsolin segment 1-actin complex and the mechanism of filament severing. Nature (London) 364, 685-692
14. 14 Kelly, J. W (1996) Alternative conformations of amyloidogenic proteins govern their behaviour Curr. Opin. Struct. Biol. 6, 11-17
15. 15 Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M. A., Enghild, J., Salvesen, G. S. and Roses, A. D. (1993) Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 90, 1977-1981
16. 16 Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., Hulette, C., Crain, B., Goldgaber, D. and Roses, A. D. (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43, 1467-1472
17. 17 Näslund, J., Thyberg, J., Tjernberg, L. O., Wernstedt, C., Karlstrom, A. R., Bogdanovic, N., Gandy, S., Lanfelt, L., Terenius, L. and Nordstedt, C. (1995) Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain Neuron 15, 1-20
18. 18 Chartier-Harlin, M.-C., Parfitt, M., Legrain, S., Perez-Tur, J., Brousseau, T., Evans, A. et al. (1994) Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset lorms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region. Hum. Mol. Gen. 3, 569-574
19. 19 Benjamin, R., Leake, A., Edwardson, J. A., McKeith, I. G., Ince, P. G., Perry, R. H. and Morris, C. M. (1995) Effects of apolipoprotein E genotype on cortical neuropathology in senile dementia of the Lewy body and Alzheimer's disease. Lancet 343, 1565
20. 20 Arai, H., Muramatsu, T. Higuchi, S., Sasaki, H. and Trojanowski, J. (1994) Apolipoprotein E gene in diffuse Lewy body disease with or without co-existing Alzheimer's disease. Lancet 344, 889
21. 21 Del Bo, R., Comi, G. P., Bresolin, N., Castelli, E., Conti, E., Degiuli, A., Ausenda, C. D. and Scarlato, G. (1997) The apolipoprotein E epsilon4 allele causes a faster decline of cognitive performances in Down's syndrome subjects. J. Neurol. Sci. 145, 87-91
22. 22 Schupf, N., Kapell, D., Lee, J. H., Zigman, W., Canto, B, Tycko, B. and Mayeux, R. (1996) Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome. Ann. Neurol. 40, 799-801
23. 23 Castano, E., Prelli, F., Pras, M. and Frangione, B. (1995) Apolipoprotein E carboxyl-terminal fragments are complexed to amyloids A and L. Implications for amyloidogenesis and Alzheimer's disease. J. Biol. Chem. 270, 1-6
24. 24 Soto, C., Castano E. M., Prelli, F., Kumar, R. A. and Baumann, M. (1995) Apolipoprotein E increases the fibrillogenic potential of synthetic peptides derived from Alzheimer's, Gelsolin and AA amyloids. FEBS Lett. 371, 110-114
25. 25 Bales, K. R., Verina, T., Dodel, R. C., Du, Y., Altstiel, L., Bender, M., Hyslop, P., Johnstone, E. M., Little, S. P., Cummins, D. J. et al. (1997) Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat. Genet. 17, 263-264
26. 26 Kindy, M. S. and Rader, D. J. (1998) Reduction in amyloid A amyloid formation in apolipoprotein-E-delicient mice. Am. J. Pathol. 152, 1387-1395
27. 27 Holtzman, D. M., Bales, K. R., Wu, S., Bhat, P., Parsadanian, M., Fagan, A. M., Chang, L. K., Sun, Y. and Paul, S. M. (1999) Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. J. Clin. Invest. 103, R15-R21
28. 28 Kwiatkowski, D. J., Stossel, T. P., Orkin, S. H., Mole, J. E., Colten, H. R. and Yin, H. L. (1986) Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain. Nature (London) 323, 455-458
29. 29 Schaegger, H. and von Jagow, G. (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166, 368-379
30. 30 Maury, C. P. J., Nurmiaho-Lassila, E.-L and Rossi, H. (1994) Amyloid fibril formation in Gelsolin-derived amyloidosis. Lab. Invest. 70, 558-564
31. 31 Chou, P. Y. and Fasman, G. (1978) Empirical predictions of protein conformation. Ann. Rev. Biochem. 47, 251-276
32. 32 Garnier, J., Osguthorpe, D. J. and Robson, B. (1978) Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J. Mol. Biol. 120, 97-120
33. 33 Ratnaswamy, G., Koepf, E., Bekele, H., Yin, H. and Kelly, J. (1999) The amyloidogenicity of gelsolin is controlled by proteolysis and pH. Chem. Biol. 6, 293-304
34. 34 Golabek, A. A., Solo, C., Vogel, T. and Wisniewski, T. (1996) The interaction between apolipoprotein E and Alzheimer's amyloid beta-peptide is dependent on beta-peptide conformation. J. Biol. Chem. 271, 10602-10606
35. 35 Naiki, H., Higuchi, K., Nakakuki, K. and Takeda, T. (1991) Kinetic analysis of amyloid fibril polymerization in vitro. Lab. Invest. 65, 104-110
36. 36 Castano, E. M., Prelli, F., Wisniewski, T., Golabek, A., Kumar, A., Soto, C. and Frangione, B. (1995) Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. Biochem. J. 306, 599-604
37. 37 Russe, C., Angelini, G., Dapino, D., Piccini, A., Piombo, G., Schettini, G., Chen, S., Teller, J. K., Zaccheo, D., Gambetti, P. and Tabaton, M. (1998) Opposite role of apoE in normal brains and in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 95, 15598-15602
38. 38 Soto, C., Golabek, A., Wisniewski, T. and Castano, E. M. (1996) Alzheimer's beta-amyloid peptide is conformationally modified by apolipoprotein E in vitro. Neuroreport 7, 721-725
39. 39 Exley, C., Price, N. C., Kelly, S. M. and Birchall, J. D. (1993) An interaction of beta-amyloid with aluminium in vitro. FEBS Lett. 324, 293-295
40. 40 Hyman, B. T. and Terry, R. D. (1994) Apolipoprotein E, A beta, and Alzheimer disease. J. Neuropathol. Exp. Neurol. 53, 427-428
41. 41 Dietrich, J. F., Minnigan, H., Carp, R. I., Whitaker, J. N., Race, R., Frey, II, W. and Haase, A. T. (1991) Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes. J. Virol. 65, 4759-4768
42. 42 Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E. and Ikeda, K. (1991) Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541, 163-166
43. 43 Charge, S. B., Esiri, M. M., Bethune, C. A., Hansen, B. C. and Clark, A. (1996) Apolipoprotein E is associated with islet amyloid and other amyloidoses: implications for Alzheimer's disease. J. Pathol. 179, 443-447
44. 44 Tjernberg, L. O., Callaway, D. J. E., Tjernberg, A., Hahne, S., Lilliehöök, C., Terenius, L., Thyberg, J. and Nordstedt, C. (1999) A molecular model of Alzheimer's amyloid-peptide flbril formation. J. Biol. Chem. 274, 12619-12625
45. 45 Gasset, M., Baldwin, M. A, Lloyd, D., H., Gabriel, J. M., Holtzman, D. M., Cohen, F., Fletterick, R. and Prusiner, S. B. (1992) Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid. Proc. Natl. Acad. Sci. U.S.A. 89, 10940-10944
46. 46 Glenner, G. G., Eanes, D. E. and Wiley, C. A. (1988) Amyloid fibrils formed from a segment of the pancreatic islet amyloid protein. Biochem. Biophys. Res. Commun. 155, 608-614
47. 47 Westermark, P., Engström, U., Johnson, K. H., Westermark, G. T. and Betsholtz, C. (1990) Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. Proc. Natl. Acad. Sci. U.S.A. 87, 5036-5040
48. 48 Gustavsson, Ȧ., Engström, U. and Westermark, P. (1991) Normal transthyretin and synthetic transthyretin fragments form amyloid-like fibrils in vitro. Biochem. Biophys. Res. Commun. 175, 1159-1164
49. 49 Hurle, M. R., Helms, L. R., Li, L., Chan, W. and Wetzel, R. (1994) A role for destabilizing amino acid replacements in light-chain amyloidosis. Proc. Natl. Acad. Sci. U.S.A. 91, 5446-5450
50. 50 Turnell, W. G. and Finch, J. T. (1992) Binding of the dye Congo red to the amyloid protein pig insulin reveals a novel homology amongst amyloid-forming peptide sequences. J. Mol. Biol. 227, 1205-1223
51. 51 Kurochkin, I. V. (1998) Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme. FEBS Lett. 427, 153-156
52. 52 Baumann, M., Wisniewski, T., Levy, E., Plant, G. and Ghiso, J. (1996) C-terminal fragments of alpha-and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type Biochem. Biophys. Res. Commun. 219, 238-242
53. 53 Guijarro, J. I., Sunde, M., Jones, J. A., Campell, I. D. and Dobson, C. M. (1998) Amyloid fibril formation by an SH3 domain. Proc. Natl. Acad. Sci. U.S.A. 95, 4224-4228
54. 54 Scherzinger, E., Lurz, R., Turmaine, M., Mangiarini, L., Hollenbach, B., Hasenbank, R., Bates, G. P., Davies, S. W., Lehrach, H. and Wanker, E. E. (1997) Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Cell 90, 549-558
55. 55 Chili, F., Webster, P., Taddei, N., Clark, A., Stefani, M., Ramponi, G. and Dobson, C. M. (1999) Designing conditions for in intro formation of amyloid protofilaments and fibrils. Proc. Natl. Acad. Sci. U.S.A. 96, 3590-3594
56. 56 Strittmatter, W. J., Weisgraber, K. J., Huang, D. Y., Dong, L.-H., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D. and Roses, A. D. (1993) Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific eflects and implications for late-onset Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 90, 8098-8102
57. 57 Pillot, T., Goethals, M., Jamilla, N., Labeur, C., Lins, L., Chambaz, J., Brasseur, R., Vandekerckhove, J. and Rosseneu, M. (1999) β-amyloid interacts with the carboxy-terminal domain of human apolipoprotein E: relevance to Alzheimer's disease. J. Neurochem. 72, 230-237