Mitochondrial dysfunction induced by oxidative stress in the brains of hamsters infected with the 263 K scrapie agent

Acta Neuropathologica

Volumn 96, Issue 3, 1998, Pages 279-286

  Choi, Seung Il ^a   Ju, Won Kyu ^a   Choi, Eun Kyoung ^a   Kim, Jin ^b   Lea, Ho Zoo ^d   Carp, R I ^c   Wisniewski, H M ^c   Kim, Yong Sun ^a  

^a Hallym University   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^d Kangwon National University   (South Korea)

Author keywords

Mitochondrial dysfunction; Neurodegeneration; Oxidative stress; Scrapie

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANTIOXIDANT; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C OXIDASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; BRAIN CORTEX; BRAIN MITOCHONDRION; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; DEATH; DEGENERATIVE DISEASE; ENZYME ACTIVITY; FEMALE; HAMSTER; HIPPOCAMPUS; LATENT PERIOD; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PRION DISEASE; PRIORITY JOURNAL; SCRAPIE AGENT; SHEEP; SYMPTOM; TREMOR; VIRUS INFECTION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTIOXIDANTS; BRAIN; CATALASE; CRICETINAE; CYTOSOL; ELECTRON TRANSPORT COMPLEX IV; ENZYME ACTIVATION; FEMALE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LIPID PEROXIDATION; MICROSCOPY, ELECTRON; MITOCHONDRIA; OXIDATIVE STRESS; PRION DISEASES; REACTIVE OXYGEN SPECIES; SCRAPIE; SUPEROXIDE DISMUTASE;

EID: 0031710192     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050895     Document Type: Article

References (31)

1. Balazs L, Leon M (1994) Evidence of an oxidative challenge in the Alzheimer's brain. Neurochem Res 19: 1131-1137
2. Bannister JV, Bannister WH, Rotilio G (1987) Aspects of the structure, function, and applications of superoxide dismutase. CRC Crit Rev Biochem 22: 111-180
3. Beal MF (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 38: 357-366
4. Beer RF Jr, Sizer IW (1952) A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 195: 133-140
5. Bolanos P, Peuchen S, Heales SJ, Land JM, Clark JB (1994) Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J Neurochem 63: 910-916
6. Troy CM, Derossi D, Prochiantz A, Greene LA, Shelanski ML (1996) Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrate pathway. J Neurosci 16: 253-261
7. Carp RI, Ye X, Kascsak RJ, Rubenstein R (1994) The nature of the scrapie agent: scrapie strain-host combinations. Ann NY Acad Sci 724: 221-234
8. DeArmond SJ, Prusiner SB (1995) Etiology and pathogenesis of prion diseases. Am J Pathol 146: 785-811
9. Gajdusek DC (1977) Unconventional viruses and origin and disappearance of kuru. Science 197: 943-960
10. Benzi G, Moretti A (1995) Age-and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system. Free Radic Biol Med 19: 77-101
11. Halliwell B, Gutteridge JM (1984) Oxygen toxicity, transition metals and disease. Biochem J 219: 1-14
12. Halliwell B, Gutteridge JM (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186: 1-88
13. Hauswirth WW, Lim LOL, Dujon B, Turner G (1987) Methods for studying the genetics of mitochondria. In: Darley-Usmar VM, Rickwood D, Wilson MT (eds) Mitochondria: a practical approach. IRL Press, Oxford, pp 171-173
14. Holmes RS, Masters CJ (1969) On the tissue and subcellular distribution of multiple forms of catalase in the rat. Biochim Biophys Acta 191: 488-490
15. Horn HD (1963) Methods of enzymatic analysis. In: Bergmeyer HU (ed) Glutathione reductase. Academic Press, New York, pp 875-879
16. Ischiropoules H, Zhu L, Chen J, Tsai M, Martin JC, Smith CD, Beckman JS (1992) Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys 298: 431-437
17. Kim YS, Carp RI, Callahan SM, Wisniewski HM (1990) Incubation periods and histopathological changes in mice injected stereotaxically in different brain areas with the 87V scrapie strain. Acta Neuropathol 80: 388-392
18. Kimberlin RH, Walker CA (1977) Characteristics of a short incubation model of scrapie in the golden hamster. J Gen Virol 34: 295-304
19. Yamada K, Nabeshima T (1997) Two pathways of nitric oxide production through glutamate receptors in the rat cerebellum in vivo. Neurosci Res 28: 93-102
20. Lowenstein CJ, Snyder SH (1992) Nitric oxide, a novel biologic messenger. Cell 70: 705-707
21. Lowry OH (1957) Micromethods tor the assay of enzymes. Methods Enzymol, pp 366-381
22. Marletta MA (1993) Nitric oxide synthase structure and mechanism. J Biol Chem 26: 12231-12234
23. McCord J, Fridovich I (1969) Superoxide dismutase an enzymatic function for erythrocuprein. J Biol Chem 244: 6049-6055
24. Minc-Golomb D, Yadid G, Tsarfaty I, Resau JH, Schwartz JP (1996) In vivo expression of inducible nitric oxide synthase in cerebellar neurons. J Neurochem 66: 1504-1509
25. Moncada S, Palmer RM, Higgs EA (1991) Nitric oxide: physiology, pathology, and pharmacology. Pharmacol Rev 43: 109-142
26. Nathan C (1992) Nitric oxide as a secretory product of mammalian cells. FASEB J 6: 3051-3064
27. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358
28. Paglia DE, Valentine WN (1967) Studies on the quantitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70: 158-169
29. Phan SM, Mahler HR (1976) Studies on cytochrome c oxidase. J Biol Chem 251: 257-269
30. Wisniewski HM, Wegiel J, Kozielski R (1994) Amyloidosis in prion diseases and cells involved in PrP fibrinogenesis. Ann NY Acad Sci 724: 191-209
31. Won-Kyu Ju, Kyu-Jin Park, Eun-Kyoung Choi, Jin Kim, Carp RI, Wisniewski HM, Yong-Sun Kim (1998) Expression of iNOS in the brain of scrapie-infected mice. J Neurovirol (in press)