Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens

Journal of Medicinal Chemistry

Volumn 44, Issue 24, 2001, Pages 4137-4156

  Ma, Z ^a   Clark, R F ^a   Brazzale, A ^a   Wang, S ^a   Rupp, M J ^a   Li, L ^a   Griesgraber, G ^a   Zhang, S ^a   Yong, H ^a   Ly Tam Phan, ^a   Nemoto, P A ^a   Chu, D T W ^a   Plattner, J J ^a   Zhang, X ^a   Zhong, P ^a   Cao, Z ^a   Nilius, A M ^a   Shortridge, V D ^a   Flamm, R ^a   Mitten, M ^a   Meulbroek, J ^a   Ewing, P ^a   Alder, J ^a   Yat Sun Or, ^a   more..

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CLARITHROMYCIN; ERYTHROMYCIN DERIVATIVE; HMR 3004; PROTEIN SYNTHESIS INHIBITOR; TE 802; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; LUNG INFECTION; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; ANTI-BACTERIAL AGENTS; CARBAMATES; CELL-FREE SYSTEM; DRUG RESISTANCE, MULTIPLE; ERYTHROMYCIN; HAEMOPHILUS INFLUENZAE; KETOLIDES; LUNG; MICE; MODELS, MOLECULAR; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RATS; RESPIRATORY TRACT INFECTIONS; RIBOSOMES; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 0035935738     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0102349     Document Type: Article

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