Mechanisms of bacterial resistance to macrolide antibiotics

Journal of Infection and Chemotherapy

Volumn 5, Issue 2, 1999, Pages 61-74

  Nakajima, Yoshinori ^a  

^a HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Antibiotic; Bacteria; Decreased accumulation; Efflux; Erm; Inactivation; Macrolide; Resistance

Indexed keywords

4'' O (4 METHOXYPHENYLACETYL)TYLOSIN; AZITHROMYCIN; CLARITHROMYCIN; CLINDAMYCIN; DIRITHROMYCIN; ERYTHROMYCIN; FLURITHROMYCIN; JOSAMYCIN; KITASAMYCIN; LINCOMYCIN; MACROLIDE; MIKAMYCIN B; OLEANDOMYCIN; ROKITAMYCIN; SPIRAMYCIN; TE 810; TELITHROMYCIN; TYLOSIN; UNCLASSIFIED DRUG; YM 133;

ANTIBIOTIC RESISTANCE; BACTERIAL GENE; BACTERIAL INFECTION; DRUG ACETYLATION; DRUG HYDROLYSIS; DRUG INACTIVATION; DRUG PROTEIN BINDING; DRUG UPTAKE; ESCHERICHIA COLI; GENE MUTATION; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN EXPRESSION; REVIEW;

EID: 0032982254     PISSN: 1341321X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s101560050011     Document Type: Review

References (125)

1. Chabbert Y, Hervé J. In vitro antagonism between erythromycin and spiramycin. Ann Inst Pasteur 1956;90:787-90.
2. Woodward RB. Structure and biogenesis of the macrolides. Angew Chem 1957;69:50-8.
3. Taubman SB, Jones NR, Young FE, Corcoran JW. Sensitivity and resistance to erythromycin in Bacillus subtilis 168: the ribosomal binding of erythromycin and chloramphenicol. Biochem Biophys Acta 1966;123:438-40.
4. Bryskier A, Agouridas C, Chantot J-F. New insights into the structure-activity relationship of macrolides and azalides. In: Neu HC, Young LS, Zinner SH, Acar JF, editors. New macrolides, azalides, and streptogramins in clinical practice. New York: Marcel Dekker; 1995:3-30.
5. McGuire JM, Bunch RL, Anderson RC, Boaz HE, Flynn EH, Powell HM, Smith JW. "Ilotycin", a new antibiotic. Antibiot Chemother 1952;2:281-3.
6. Haight TH, Finland M. Resistance of bacteria to erythromycin, Proc Soc Exp Biol Med 1952;81:183-8.
7. Westh H, Hougaard DM, Vuust J, Rosdahl VT. Prevalence of erm gene classes in erythromycin-resistant Staphylococcus aureus strains isolated between 1959 and 1988. Antimicrob Agents Chemother 1995;39:369-73.
8. Garrod LP. The erythromycin group of antibiotics. BMdJ 1957;2:57-63.
9. Jones WF, Nichols RL, Finland M. Development of resistance and cross-resistance in vitro to erythromycin, carbomycin, oleandomycin and streptogramin. Proc Soc Exp Biol Med 1966;93:388-93.
10. Lampson BC, Parisi JT. Naturally occurring Staphylococcus epidermidis plasmid expressing constitutive macrolide-lincosamide-streptogramin B resistance contains a deleted attenuator. J Bacteriol 1986;166:479-83.
11. Thakker-Varia S, Jenssen WD, Moon-McDermott L, Weinstein MP, Dubin DT. Molecular epidemiology of macrolide-lincosamide-streptogramin B resistance in Staphylococcus aureus and coagulase-negative staphylococci. Antimicrob Agents Chemother 1987;31:735-43.
12. Horinouchi S, Byeon WH, Weisblum B. A complex attenuator regulates inducible resistance to macrolides, Iincosamides, and streptogramin type B antibiotics in Streptococcus sanguis. J Bacteriol 1983;154:1252-62.
13. Shaw JH, Clewell DB. Complete nucleotide sequence of macrolide-lincosamide-streptogramin B-resistance transposon Tn917 in Streptococcus faecalis. J Bacteriol 1985;164:782-96.
14. Serwold-Davis TM, Groman NB. Identification of a methylase gene for erythromycin resistance within the sequence of a spontaneously deleting fragment of Corynebacterium diphtheriae plasmid pNG2. FEMS Microbiol Lett 1988;46:7-14.
15. Berryman DI, Rood JI. Cloning and hybridization analysis of ermP, a macrolide-lincosamide-streptogramin B resistance determinant from Clostridium perfringens. Antimicrob Agents Chemother 1989;33:1346-53.
16. Berryman DI, Lyristis M, Rood JI. Cloning and sequence analysis of ermQ, the predominant macrolide-lincosamide-streptogramin B resistance gene in Clostridium perfringens. Antimicrob Agents Chemother 1994;38:1041-6.
17. Hächler H, Berger-Bächi B, Kayser FH. Genetic characterization of a Clostridium difficile erythromycin-clindamycin resistance determinant that is transferrable to Staphylococcus aureus. Antimicrob Agents Chemother 1987;31:1039-45.
18. Monod M, Denoya C, Dubnau D. Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis. J Bacteriol 1986;167:138-47.
19. Monod M, Mohan S, Dubnau D. Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B reisistance element from Bacillus sphaericus. J Bacteriol 1987;169:340-50.
20. Gryczen T, Israelic-Reches M, Del Bue M, Dubnau D. DNA sequence and regulation of ermD, a macrolide-lincosamide-streptogramin B resistance element from Bacillus licheniformis. Mol Gen Gent 1984;194:349-56.
21. Kim H-S, Choi E-C, Kim B-K. A macrolide-lincosamide-streptogramin B resistance determinant from Bacillus anthracis 590: cloning and expression of ermJ. J Gen Microbiol 1993;139: 601-7.
22. Kwak J-H, Choi E-C, Weisblum B. Transcriptional attenuation control of ermK, a macrolide-lincosamide-streptogramin B resistance determinant from Bacillus licheniformis. J Bacteriol 1991;173:4725-35.
23. Tannock GW, Luchansky JB, Miller L, Connell H, Thode-Andersen S, Mercer AA, Klaenhammer TR. Molecular characterization of a plasmid-borne (pGT633) erythromycin resistance determinant (ermGT) from Lactobacillus reuteri 100-63. Plasmid 1994;31:60-71.
24. Eady EA, Ross JI, Cove JH, Holland KT, Cundliffe WJ. Macrolide-lincosamide-streptogramin B (MLS) resistance in cutaneous propionibacteria: definition of phenotype. J Antimicrob Chemother 1989;23:493-502.
25. Rasmussen JL, Odelson DA, Macrina FL. Complete nucleotide sequence and transcription of ermF, a macrolide-lincosamide-streptogramin B resistance determinant from Bacteroides fragilis. J Bacteriol 1986;168:523-33.
26. Smith CJ. Nucleotide sequence analysis of Tn4551: use of ermFS operon fusions to detect promoter activity in Bacteroides fragilis. J Bacteriol 1987;169:4589-96.
27. Halula MC, Manning S, Macrina FL. Nucleotide sequence of ermFU, a macrolide-lincosamide-streptogramin (MLS) resistance gene encoding an RNA methylase from the conjugal element of Bacteroides fragilis V503. Nucleic Acids Res 1991;19: 3453.
28. Brisson-Noël A, Arthur M, Courvalin P. Evidence for natural gene transfer from Gram-positive cocci to Escherichia coli. J Bacteriol 1988;170:1739-45.
29. Arthur M, Andremont A, Courvalin P. Distribution of erythromycin esterase and RNA methylase gene in members of the family Enterobacteriaceae highly resistant to erythromycin. Antimicrob Agents Chemother 1987;31:404-9.
30. Kamimiya S, Weisblum B. Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streplomyces fradiae. J Bacteriol 1988;170:1800-11.
31. Zalacain M, Cundliffe E. Methylation of 23S rRNA by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. J Bacteriol 1989;171:4254-60.
32. Zalacain M, Cundliffe E. Cloning of tlrD, a fourth resistance gene, from the tylosin producer, Streplomyces fradiae. Gene 1991; 97:137-42.
33. Epp JK, Burgett SG, Schoner BE. Cloning and nucleotide sequence of carbomycin-resistance gene from Streptomyces thermotolerans. Gene 1987;53:73-83.
34. Caleutt MJ, Cundliffe E. Cloning of a lincosamide resistance determinant from Streptomyces caelestis, the producer of celesticetin and characterization of the resistance mechanism. J Bacteriol 1990;172:4710-4.
35. Zhang H-Z, Schmidt H, Piepersberg W. Molecular cloning and characterization of two lincomycin-resistance genes, ImrA and ImrB, from Streptomyces lincolnensis 78-11. Mol Microbiol 1992; 6:2147-57.
36. Jenkins G, Cundliffe E. Cloning and characterization of two genes from Streptomyces lividans that confer inducible resistance to lincomycin and macrolide antibiotics. Gene 1991;108:55-62.
37. Hara O, Hutchinson CR. Cloning of midecamycin (MLS)-resistance genes from Streptomyces mycarofaciens, Streptomyces lividans and Streptomyces coelicolor A3(2). J Antibiot 1990;43: 977-91.
38. Inouye M, Morohoshi T, Horinouchi S, Beppu T. Cloning and sequences of two macrolide-resistance-encoding genes from mycinamicin-producing Micromonospora griseorubida. Gene 1994;141:39-46.
39. Uchiyama H, Weisblum B. N-Methyl transferase of Streptomyces erythreus that confers resistance to the macrolide-lincosamide-streptogramin B antibiotics: amino acid sequence and its homology to cognate R-factor enzymes from pathogenic bacilli and cocci. Gene 1985;38:103-10.
40. Roberts AN, Hudson GS, Brenner S. An erythromycin-resistance gene from an erythromycin-producing strain of Arthrobacter sp. Gene 1985;35:259-70.
41. Weisblum B. Erythromycin resistance by ribosome modification. Antimicrob Agents Chemother 1995;39:577-85.
42. Ross JI, Eady EA, Cove JH, Cunliffe WJ, Baumberg S, Wootton JC. Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family. Mol Microbiol 1990;4:1207-14.
43. Lampson BC, David WV, Parisi JT. Novel mechanism for plasmid-mediated erythromycin resistance by pNE24 from Staphylococcus epidermidis. Antimicrob Agents Chemother 1986;30: 653-8.
44. Wondrack L, Massa M, Yang BV, Sutcliffe J. Clinical strain of Staphylococcus aureus inactivates and causes efflux of macrolides. Antimicrob Agents Chemother 1996;40:992-8.
45. Monro RE, Vazquez D. Ribosome-catalyzed peptidyl transfer: effect of some inhibitors of protein synthesis. J Mol Biol 1967; 28:161-5.
46. Vazquez D. Inhibitors of protein synthesis at the ribosome level. Site of action. Life Sci 1967;6:381-6.
47. Cerná J, Jonak J, Rychlik I. Effects of macrolide antibiotics on the ribosomal peptidyl transferase in cell-free systems derived from Escherichia coli B and erythromycin-resistant mutant of Escherichia coli B. Biochim Biophys Acta 1971;240:109-21.
48. Mao JC-H, Robishaw EE. Erythromycin, a peptidyltransferase effector. Biochemistry 1972;11:4864-72.
49. Vogel Z, Vogel T, Elson D. Effect of erythromycin on peptide bond formation and the termination reaction. FEBS Lett 1971;15:249-53.
50. Nakajima Y, Takeda R, Tani K, Endou K, Matsuoka M, Yamagishi S. Greatly improved activity of staphylococcal ribosomes in polyadenylate directed polylysine synthesis: as an assay system for investigating their sensitivity to macrolide antibiotics. J Pharmacobiodyn 1990;13:378-83.
51. Davis J. What are antibiotics? Archaic functions for modern activities. Mol Microbiol 1990;4:1227-32.
52. Crick FHC. The origin of the genetic code. J Mol Biol 1968; 38:367-79.
53. Wittman HG, Stöffler G, Apirion D, Rosen L, Tanaka K, Tamaki L, et al. Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins. Mol Gen Gent 1973;127:175-89.
54. Noller HF, Kop J, Wheaton V, Brosius J, Gutell RR, Kopylov AM, et al. Secondary structure model for 23S ribosomal RNA. Nucleic Acids Res 1981;9:6167-89.
55. Douthwaite S, Prince JB, Noller HF. Evidence for functional interaction between domains II and V of 23S ribosomal RNA from an erythromycin mutant. Proc Natl Acad Sci USA 1985; 82:8330-4.
56. Douthwaite S. Functional interactions within 23S rRNA involving peptidyltransferase center. J Bacteriol 1992;174:1333-8.
57. Noller HF, Hoffarth V, Zimniak L. Unusual resistance of peptidyl transferase to protein extraction procedures. Science 1992;256: 1416-9.
58. Nitta I, Ueda T, Watanabe K. Possible involvement of Escherichia coli 23S ribosomal RNA in peptide bond formation. RNA 1998;4:257-67.
59. Nitta I, Kamada Y, Noda H, Ueda T, Watanabe K. Reconstitution of peptide bond formation with Escherichia coli 23S rRNA ribosomal RNA domains. Science 1998;281:666-9.
60. Versalovic J, Shortridge D, Kibler K, Griffy MV, Beyer J. Flamm RK, et al. Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori. Antimicrob Agents Chemother 1996;40:477-80.
61. Lai CJ, Weisblum B. Altered methylation of ribosomal RNA in an erythromycin-resistant strain of Staphylococcus aureus. Proc Natl Acad Sci USA 1971;68:856-00.
62. Egebjerg J, Larsen N, Garrett RA. Structural map of 23S rRNA. In: Hill WE, Dahlberg A, Garrett RA, Moore PB, Schlessinger D, Warner JR, editors. The ribosome: structure, function, and evolution. Washington, DC: American Society for Microbiology; 1990:168-79.
63. Shivakumar AG, Hahn J, Grandi G, Kozlov Y, Dubnau D. Posttranscriptional regulation of an erythromycin resistance protein specified by plasmid pE194. Proc Natl Acad Sci USA 1980; 7:3903-7.
64. Horinouchi S, Weisblum B. Posttranscriptional modification of mRNA conformation: mechanism that regulates erythromycin-induced resistance. Proc Natl Acad Sci USA 1980;77:7079-83.
65. Choi S-S, Kim S-K, Oh T-G, Choi E-C. Role of mRNA termination in regulation of ermK. J Bacteriol 1997;179:2065-7.
66. Meier A, Kirschner P, Springer B, Steingrub VA, Brown BA, Wallace RJ, Böttger EC. Identification of mutations in the 23S ribosomal RNA gene of clarithromycin resistant Mycobacterium intracellulare. Antimicrob Agents Chemother 1994;38: 381-4.
67. Moazed D, Noller HF. Chloramphenicol, erythromycin and vernamycin B protect overlapping site in the peptidyl transferase region of 23S ribosomal RNA. Biochemie 1987;69:879-84.
68. Douthwaite S, Aagaard C. Erythromycin binding is reduced in ribosomes with conformational alterations in the 23S rRNA peptidyl transferase loop. J Mol Biol 1993;232:725-31.
69. Fernandez-Muñoz R, Monro RE, Torres-Pinedo R, Vazquez D. Substrate and antibiotic-binding sites at the peptidyltransferase center of Escherichia coli ribosomes. Studies on the chloramphenicol, lincomycin and erythromycin sites. Eur J Biochem 1971;23:185-93.
70. Nakajima Y, Inoue M, Oka Y, Yamagishi S. A mode of resistance to macrolide antibiotics in Staphylococcus aureus. Jpn J Microbiol 1968;12:248-50.
71. Yamagishi S, Nakajima Y, Inoue M, Oka Y. Decrease in accumulation of macrolide antibiotics as a mechanism of resistance in Staphylococcus aureus. Jpn J Microbiol 1971;15:39-52.
72. Weisblum B. Inducible resistance to macrolides, lincosamides and streptogramin type B antibiotics: the resistance phenotype, its biological diversity, and structural elements that regulate expression - a review. J Antimicrob Chemother 1985;16:(Suppl A):63-90.
73. Weisblum B. Insights into erythromycin action from studies of its activity as inducer of resistance. Antimicrob Agents Chemother 1995;39:797-805.
74. Leclercq R, Couvalin P. Bacterial resistance to macrolide, lincosamides, and streptogramin antibiotics by target modification. Antimicrob Agents Chemother 1991;35:1267-72.
75. Nakajima Y. Macrolides, the attractive antibiotics - from a structural and functional aspect, (in Japanese). Jpn J Bacterol 1995;50: 717-36.
76. Weisblum B. Macrolide resistance. Drug Resistance Updates 1998;1:29-41.
77. Wang G, Taylor DE. Site-specific mutations in the 23S rRNA gene of Helicobacter pylori confer two types of resistance to macrolide-lincosamide-streptogramin B antibiotics. Antimicrob Agents Chemother 1998;42:1952-8.
78. Ross JI, Eady EA, Cove JE, Jones CE, Ratyal AH, Miller YW, et al. Clinical resistance to erythromycin and clindamycin in cutaneous Propionibacteria isolated from acne patients is associated with mutations in 23S rRNA. Antimicrob Agents Chemother 1997;41:1162-5.
79. Dam M, Douthwait S, Tenson T, Mankin AS. Mutation in domain II of 23S rRNA facilitates translation of a 23S rRNA-encoded pentateptide conferring erythromycin resistance. J Mol Biol 1996;259:1-6.
80. Tenson T, DelBlasio A, Mankin A. A functional peptide encoded in the Escherichia coli 23S rRNA. Proc Natl Acad Sci USA 1997;93:5641-6.
81. Douthwaite S, Powers T, Lee JY, Noller HF. Defining the structural requirements for a helix in 23S ribosomal RNA that confers erythromycin resistance. J Mol Biol 1989; 209:655-65.
82. Tenson T, Xiong L, Kloss O, Mankin AS. Erythromycin resistance peptides selected from random peptide libraries. J Biol Chem 1997;272:17425-30.
83. Ross JI, Farrell AM, Eady EA, Cove JH, Cunliffe WJ. Characterization and molecular cloning of the novel macrolidestreptogramin B resistance determinant from Staphylococcus epidermidis. J Antimicrob Chemother 1989;24:851-62.
84. Ross JI, Eady EA, Cove JH, Baumberg S. Minimal functional system required for expression of erythromycin resistance by insrA in Staphylococcus aureus RN4220. Gene 1996;183:143-8.
85. Goldman RC, Capobianco JO. Role of an energy-dependent efflux pump in plasmid pNE24-mediated resistance to 14- and 15-membered macrolides in Staphylococcus epitlermidis. Antimicrob Agents Chemother 1990;34:1973-80.
86. Paulsen IT, Brown MH, Skurray RA. Proton-dependent multidrug efflux systems. Microbiol Rev 1996;60:575-608.
87. Lewis K. Multidrug resistance pumps in bacteria: variations on a theme. Trends Biochem Sci 1994;19:119-23.
88. Clancy J, Petitpas J, Dib-Hajj F, Yuan W, Cronan M, Kamath AV, et al. Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, Streptococcus pyogenes. Mol Microbiol 1996;22:867-79.
89. Tait-Kamaradt A, Clancy J, Cronan M, Dib-Hajj F, Wondrack L, Yuan W, Sutcliffe J. mefE is necessary for erythromycin-resistant M phenotype in Streptococcus pneumoniae. Antimicrob Agents Chemother 1997;41:2251-5.
90. Clancy J, Dib-Hajj F, Petitpas J, Yuan W. Cloning and characterization of a novel macrolide efflux gene, mreA, from Streptococcus agalactiae. Antimicrob Agents Chemother 1997;41:2719-23.
91. Jánosi L, Nakajima Y, Hashimoto H, Characterization of plasmids that confer inducible resistance to 14-membered macrolide and streptogramin type B antibiotics in Staphylococcus aureus. Microbiol Immunol 1990;34:723-35.
92. Matsuoka M, Endou K, Saitoh S, Katoh M, Nakajima Y. A mechanism of resistance to partial macrolide and streptogramin B antibiotics in Staphylococcus aureus clinically isolated in Hungary. Biol Pharm Bull 1995;18:1482-6.
93. Matsuoka M, Nakajima Y. A distinctive effect of CCCP on the transfer of erythromycin to 1-octanol: as a possible model for playing a role in promoting the intracellular antibiotic-accumulation through lipid in a staphylococcal cytoplasmic membrane. Res Commun Mol Pathol Pharmacol 1996;92:85-93.
94. Mao J C-H, Wiegand RG. Mode of action of macrolides. Biochim Biophys Acta 1968;157:404-13.
95. Gryczan T, Grandi G, Hahn J, Grandi R, Dubnau D. Confomational alteration of mRNA structure and the posttranscriptional regulation of erythromycin-induced drug resistance. Nucleic Acids Res 1980;8:6081-97.
96. Matsuoka M, Endou K. Kobayashi H, Inoue M, Nakajima Y. A dyadic plasmid that shows MLS and PMS resistance in Staphylococcus aureus. FEMS Microbiol Lett 1997;148:91-6.
97. Matsuoka M, Endou K, Kobayashi H, Inoue M, Nakajima Y. A plasmid that encodes three genes for resistance to macrolide antibiotics in Stapliylococcus aureus. FEMS Microbiol Lett 1998;167:221-7.
98. Endou K, Matsuoka M, Nakajima Y. Adhesive binding of rokitamycin to Stapliylococcus aureus ribosomes. FEMS Microbiol Lett 1990;72:93-6.
99. Agouridas C, Bonnefoy A, Chantot J-F. HMR3647: antibacterial activity and resistance, (abstract 1.24). In: Abstracts of the 4th international conference on the macrolides, azalides, streptogramins and ketolides. Barcelona: ICMAS; 1998:25.
100. Jones RN, Biedenbach DJ. Antimicrobial activity of RU66647, a new ketolide. Diagn Microbiol Infect Dis 1997;27:7-12.
101. Mao J C-H, Putterman M. The intermolecular complex of erythromycin and ribosome. J Mol Biol 1969; 44:347-61.
102. Wilhelm JM, Oleinick NL, Corcoran JW. Interaction of antibiotics with ribosomes: structure-function relationships and a possible common mechanism for the antibacterial action of the macrolides and lincomycin. Antimicrob Agents Chemother 1968;1967:236-49.
103. Igarashi K, Ishizuka H, Kaji A. Comparative studies on the mechanism of action of lincomycin, streptogramin, and erythromycin. Biochem Biophys Res Comm 1969;37:499-504.
104. Igarashi K, Kaji A. Evidence for one functional phenylalanyl-tRNA binding site on the 30S ribosomal subunit. Proc Natl Acad Sci USA 1969;62:498-505.
105. Mao J C-H, Robishaw EE. Effects of macrolides on peptidebond formation and translocation. Biochemistry 1971;10:2054-61.
106. Ennis HL. Polysome metabolism in Escherichia coli. Effect of antibiotics on polysome stability. Antimicrob Agents Chemother 1972;1:197-203.
107. Cundliffe E, McQuillen K. Bacterial protein synthesis: the effect of antibiotics. J Mol Biol 1967;30:137-46.
108. Cundliffe E. Antibiotics and polyribosomes. II. Some effects of lincomycin, spiramycin, and streptogramin A in vivo. Biochemistry 1969;8:2063-6.
109. Menninger JR, Otto DP. Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissocia-tion of peptidyl-tRNA from ribosomes. Antimicrob Agents Chemother 1982;21:811-8.
110. Murphy E. Nucleotide sequence of ermA, a macrolide-lincosamide-streptogramin B determinant in Staphylococcus aureus. J Bacteriol 1985;162:633-40.
111. Matsuoka M, Inoue M, Nakajima Y. A new class of erm genes mediating MLS-coresistance in Staphylococcus aureus: it resides on plasmid pMS97 together with msrSA' gene coding for an active efflux pump. American Society for Microbiology, 38th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Diego, California, 1998 (abstract 14352).
112. Lampson BC, Parisi JT. Nucleotide sequence of the constitutive macrolide-lincosamide-streptogramin B resistance plasmid pNE131 from Staphylococcus epidermidis and homologies with Staphylococcus aureus plasmid pE194 and pSN2. J Bacteriol 1986;167:888-92.
113. Oh T-G, Kwon A-R, Choi E-C. Induction of ermAMR from a clinical strain of Enterococcus faecalis by 16-membered-ring macrolide antibiotics. J Bacteriol 1998;180:5788-91.
114. Serwold-Davis TM, Groman NB. Mapping and cloning of Corynebacterium diplitlieriae plasmid pNG2 and characterization of its relatedness to plasmid from skin coryneforms. Antimicrob Agents Chemother 1986;30:69-72.
115. Hodgson ALM, Krywult J, Radford AJ. Nucleotide sequence of the erythromycin resistance gene Corynebacterium plasmid pNG2. Nucleic Acids Res 1990;18:1891.
116. Occhialini A, Urdaci M, Doucet-Populaire F, Bébéar CM, Lamouliatte H, Mégraud F. Macrolide resistance in Helicobacter pylori: rapid detection of point mutations and assays of macrolide binding to ribosomes. Antimicrob Agents Chemother 1997;41: 2724-8.
117. Sutcliffe J, Tait-Kamradt A, Wondrack L. Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system. Antimicrob Agents Chemother 1996;40:1817-24.
118. Ounissi H, Courvalin P. Nucleotide sequence of the gene ereA encoding the erythromycin esterase in Escherichia coli. Gene 1985;35:271-8.
119. Authur M. Autissier D, Courvalin P. Analysis of the nucleotide sequence of the ereB gene encoding the erythromycin esterase type II. Nucleic Acids Res 1986;14:4987-99.
120. Allignet J, Loncle V, Mazodier P, Nevine EL Solh. Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginamycin-like antibiotics. Plasmid 1988;20:271-5.
121. O'hara K, Kanda T, Ohmiya K, Ebisu T, Kono M. Purification and characterization of macrolide 2′-phosphotransferase from a strain of E. coli that is highly resistant to erythromycin. Antimicrob Agents Chemother 1989;33:1354-7.
122. Noguchi N, Katayama J, O'hara K. Cloning and nucleotide sequence of the mphB gene for macrolide 2′-phosphotransferase II in Escherichia coli. FEMS Microbiol Lett 1996;144:197-202.
123. Kim SK, Baek MC, Choi SS, Kim BK, Choi EC. Nucleotide sequence, expression and transcriptional analysis of the Escherichia coli mphK gene encoding macrolide phosphotransferase. Mol Cells 1996;6:153-60.
124. Brisson-Noël A, Delrieu P. Samain D, Courvalin P. Inactivation of lincosamide antibiotics in Staphylococcus. J Biol Chem 1988;263:15880-7.
125. Dubnau D. Translational attenuation: the regulation of bacterial resistance to the macrolide-lincosamide-streptogramin B antibiotics. CRC Crit Rev Biochem 1984;16:103-32.