Highlights of recent research on the synthesis of ketolide antibiotics

Current Opinion in Drug Discovery and Development

Volumn 3, Issue 6, 2000, Pages 807-817

  Resek, J E ^a   Wang, X C ^a   Bhatia, A V ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Antibiotics; Erythromycin; Fluorination; Ketolide; Semi synthetic

Indexed keywords

AZITHROMYCIN; CETHROMYCIN; CLARITHROMYCIN; DIRITHROMYCIN; ERYTHROMYCIN; KETOLIDE; ROXITHROMYCIN; TELITHROMYCIN;

DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; FLUORINATION; REACTION ANALYSIS; REVIEW;

EID: 0034536244     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (13)

1. Erythromycin. X. Structure of erythromycin
2. Erythromycin. XII. The isolation, properties and partial structure of erythromycin C
3. Erythromycin. I. Properties and degradation studies
4. Erythromycin series. II. Acylation of erythromycin oxime and 9-amino-3-Ocladinosyl-5-O-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12 -hexamethylpentadecane-13-olide with ester-chlorides of dicarboxylic acids
5. Synthesis and antibacterial activity of ketolides (6-Omethyl-3-oxoerythromycin derivatives): A new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens
6. Erythromycin III. Acylation of erthythromycin ozime and 9-amino-3-O-cladinosyl-5-Odesoaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamet hylpentadecan-13-olide with chlorides of some aliphatic monocarboxylic acids
7. New esters of erythromycin
8. Synthesis of (9R)-9-dihydro-6,9-anhydroerythromycin A
9. Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens
10. Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives
11. Modification of macrolide antibiotics. Synthesis of 11-deoxy-11-(carboxyamino)-6-O-methylerythromycin A 11,12-(cyclic esters) via intramolecular Michael reaction of O-carbamates with an α,β-unsaturated ketone
12. Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythtomycin-resistant and susceptible pathogens
13. β-Ketoester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides