Solution conformation of methylated macrolide antibiotics roxithromycin and erythromycin using NMR and molecular modelling. Ribosome-bound conformation determined by TRNOE and formation of cytochrome P450-metabolite complex

International Journal of Biological Macromolecules

Volumn 22, Issue 2, 1998, Pages 103-127

  Bertho, Gildas ^a   Ladam, Patrick ^a   Gharbi Benarous, Josyane ^a   Delaforge, Marcel ^a   Girault, Jean Pierre ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Cytochrome P450; Macrolide; Molecular modeling; NMR; Ribosome; Transferred nuclear Overhauser effect

Indexed keywords

CYTOCHROME P450; ERYTHROMYCIN; MACROLIDE; ROXITHROMYCIN;

ARTICLE; DRUG CONFORMATION; DRUG STRUCTURE; HYDROGEN BOND; METHYLATION; MOLECULAR DYNAMICS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT;

BACTERIA (MICROORGANISMS); STURNUS VULGARIS;

EID: 0031941856     PISSN: 01418130     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0141-8130(98)00005-1     Document Type: Article

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