Migration of T cells in vivo: Molecular mechanisms and clinical implications

Annals of Internal Medicine

Volumn 135, Issue 4, 2001, Pages 279-295

  Westermann, J ^a   Engelhardt, B ^a   Hoffmann, J C ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CHEMOKINE RECEPTOR;

ANTIBODY SPECIFICITY; APOPTOSIS; CELL INTERACTION; CELL SURVIVAL; HUMAN; IMMUNE RESPONSE; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; T LYMPHOCYTE SUBPOPULATION;

EID: 0035928636     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-135-4-200108210-00013     Document Type: Review

References (152)

1. Science, medicine, and the future: Tolerance and autoimmunity
2. Th1 and Th2 T helper cell subsets affect patterns of injury and outcomes in glomerulonephritis
3. Inflammatory skin diseases, T cells, and immune surveillance
4. The pathogenesis of mucosal inflammation in murine models of inflammatory bowel disease and Crohn disease
5. Experimental models to study molecular mechanisms underlying intestinal inflammation
6. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
7. Crohn's disease stable remission after human immunodeficiency virus infection
8. The spleen in lymphocyte migration
9. Blood transit and recirculation kinetics of lymphocyte subsets in normal rats
10. Distribution of lymphocyte subsets and natural killer cells in the human body
11. Lymphocyte subsets in the blood: A diagnostic window on the lymphoid system?
12. Lymphocyte recirculation and homing: Roles of adhesion molecules and chemoattractants
13. The physiology of lymphocyte migration through the single lymph node in vivo
14. The migration of lymphocytes across specialized vascular endothelium VII. The migration of T and B lymphocytes from the blood of the athymic, nude rat
15. Which steps in lymphocyte recirculation are regulated by interferon-γ?
16. Lymphocyte migration and immune responses
17. Heterogeneity of lymphocyte homing physiology: Several mechanisms operate in the control of migration to lymphoid and non-lymphoid organs in vivo
18. How organ-specific is the migration of 'naive' and 'memory' T cells?
19. Distribution of activated T cells migrating through the body: A matter of life and death
20. Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
21. Cell adhesion receptors in lymphoma dissemination
22. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing
23. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
24. Lymphocyte trafficking and regional immunity
25. T-cell memory: The connection between function, phenotype and migration pathways
26. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
27. + T cells of both the naive and the memory phenotype enter rat lymph nodes and Peyer's patches via high endothelial venules: Within the tissue their migratory behavior differs
28. Migration of so-called naive and memory T lymphocytes from blood to lymph in the rat. The influence of IFN-γ on the circulation pattern
29. Lymphocyte trafficking: CD4 T cells with a 'memory' phenotype (CD45RC-) freely cross lymph node high endothelial venules in vivo
30. Naive and memory T lymphocytes migrate in comparable numbers through normal rat liver: Activated T cells accumulate in the periportal field
31. Migration of naive and memory T cells in vivo
32. Topographic distribution of homing receptors on B and T cells in human gut-associated lymphoid tissue: Relation of L-selectin and integrin α4β7 to naive and memory phenotypes
33. Differences in lymphocyte subsets in the wall of high endothelial venules and the lymphatics of human palatine tonsils
34. Phenotypical characterization of cells in the thoracic duct of patients with and without systemic inflammatory response syndrome and multiple organ failure
35. Selective recruitment of lymphocyte subsets to the inflamed appendix
36. B and T lymphocyte subsets enter peripheral lymph nodes and Peyer's patches without preference in vivo: No correlation occurs between their localization in different types of high endothelial venules and the expression of CD44, VLA-4, LFA-1, ICAM-1, CD2 or L-selectin
37. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
38. Random entry of circulating lymphocyte subsets into peripheral lymph nodes and Peyer's patches: No evidence in vivo of a tissue-specific migration of B and T lymphocytes at the level of high endothelial venules
39. Transforming growth factor-β 1-induced expression of the mucosa-related integrin α E on lymphocytes is not associated with mucosa-specific homing
40. The role of β7 integrins in CD8 T cell trafficking during an antiviral immune response
41. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
42. In vivo trafficking of adoptively transferred interleukin-2 expanded tumorinfiltrating lymphocytes and peripheral blood lymphocytes. Results of a double gene marking trial
43. The migration of lymphocytes across specialized vascular endothelium. VI. The migratory behaviour of thoracic duct lymphocytes retransferred from the lymph nodes, spleen, blood, or lymph of a primary recipient
44. The entry of lymphocytes into stimulated lymph nodes. The site of selection of alloantigen-specific cells
45. T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis
46. T-lymphocyte entry into the central nervous system
47. Changes in lymphocyte circulation after administration of antigen
48. Dynamics of lymphocyte-endothelial interactions in vivo
49. Interaction of B and T lymphocyte subsets with high endothelial venules in the rat: Binding in vitro does not reflect homing in vivo
50. The role of chemokines in the microenvironmental control of T versus B cell arrest in Peyer's patch high endothelial venules
51. Platelet-mediated lymphocyte delivery to high endothelial venules
52. Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cells
53. Analysis of bovine α delta T cell interactions with E-, P-, and L-selectin. Characterization of lymphocyte on lymphocyte rolling and the effects of O-glycoprotease
54. B- and T-lymphocyte subset numbers in the migrating lymphocyte pool of the rat: The influence of interferon-γ on its mobilization monitored through blood and lymph
55. Estimation of the migration of thoracic duct lymphocytes to non-lymphoid tissues. A comparison of the distribution of radioactivity at intervals following i.v, transfusion of cells labelled with 3H, 14C, 75Se, 99mTc, 125I and 51Cr in the rat
56. Activation induces rapid and profound alterations in the trafficking of T cells
57. Expression of T lymphocyte adhesion molecules: Regulation during antigen-induced T cell activation and differentiation
58. The migration of lymphocytes across specialized vascular endothelium. I. The entry of lymphocytes into the isolated mesenteric lymph-node of the rat
59. Adhesion through L-selectin requires a threshold hydrodynamic shear
60. The effect of flow on the expression of vascular adhesion molecule-1 by cultured mouse endothelial cells
61. Erythrocytes enhance lymphocyte rolling and arrest in vivo
62. Nitric oxide modulates T-lymphocyte migration in Peyer's patches and villous submucosa of rat small intestine
63. Fever-range hyperthermia enhances L-selectin-dependent adhesion of lymphocytes to vascular endothelium
64. A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion
65. The low molecular weight Dextran 40 inhibits the adhesion of T lymphocytes to endothelial cells
66. Inhibition of leukocyte adhesion: An alternative mechanism of action for anti-inflammatory drugs
67. Lymphocyte migration across high endothelium is associated with increases in α4β1 integrin (VLA-4) affinity
68. (2+)-independent adhesion pathway in lymphocyte-endothelial cell interaction
69. α 4 integrins mediate lymphocyte attachment and rolling under physiologic flow
70. L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: Delayed rejection of allografts in L-selectin-deficient mice
71. Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice
72. Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents
73. Selective migration of the human helper-inducer memory T cell subset: Confirmation by in vivo cellular kinetic studies
74. Cutaneous lymphocyte antigen-positive T lymphocytes preferentially migrate to the skin but not to the joint in psoriatic arthritis
75. CD44 variant isoform expression in a variery of skin-associated autoimmune diseases
76. Adhesion molecules expressed on homing lymphocytes in model intestinal epithelia
77. Studies on the homing of Mycobacterium-sensitized T lymphocytes to the synovium during passive adjuvant arthritis
78. Of man and mouse: Leukocyte and endothelial adhesion molecule deficiencies
79. A central role for microvillous receptor presentation in leukocyte adhesion under flow
80. Blood leucocyte subsets of the rat: Expression of adhesion molecules and localization within high endothelial venules
81. Functional organization of secondary lymphoid organs by the chemokine system
82. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
83. The recirculation of T and B lymphocytes in the athymic, nude rat
84. A model of lymphocyte recirculation
85. High cell densiry provides potent survival signals for resting T-cells
86. Cytokine regulation of secondary lymphoid organ development
87. The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice
88. Endothelial ligands and homing of mucosal leukocytes in extraintestinal manifestations of IBD
89. Extraintestinal considerations in inflammatory bowel disease
90. Birch pollen-related foods trigger atopic dermatitis in patients with specific cutaneous T-cell responses to birch pollen antigens
91. Mechanisms in adverse reactions to food. The skin
92. Development of allergies and asthma in infants and young children with atopic dermatitis - A prospective follow-up to 7 years of age
93. Accumulation of passively transferred primed T cells independently of their antigen specificiry following central nervous system trauma
94. Measures of degeneracy and redundancy in biological networks
95. The chemokine system: Redundancy for robust outputs
96. Roles of α(4) integrins/VCAM-1 and LFA-1/ICAM-1 in the binding and transendothelial migration of T lymphocytes and T lymphoblasts across high endothelial venules
97. Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration
98. The recirculating lymphocyte pool of the rat: A systematic description of the migratory behaviour of recirculating lymphocytes
99. Migration pathways of CD4 T cell subsets in vivo: The CD45RC- subset enters the thymus via α 4 integrin-VCAM-1 interaction
100. On T cell memory: Arguments for antigen dependence
101. Both activated and nonactivated leukocytes from the periphery continuously enter the thymic medulla of adult rats: Phenotypes, sources and magnitude of traffic
102. Naive T lymphocytes traffic to inflamed central nervous system, but require antigen recognition for activation
103. Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: Implications for differential CD45 expression in T cell memory formation
104. Visualization of peptidespecific T cell immunity and peripheral tolerance induction in vivo
105. Gut-derived effector T cells circulating in the blood of the rat: Preferential re-distribution by TGFβ-1 and IL-4 maintained proliferation
106. Dissemination capacity of murine lymphoma cells is not dependent on efficient homing
107. Protection from lymphoma cell metastasis in ICAM-1 mutant mice: A posthoming event
108. Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin α4β7
109. Randomized double-blind placebo-controlled trial of recombinant humanized antibody to α4 integrin (AntegrenTM) in active Crohn's disease
110. A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease
111. Antisense ICAM-1 (ISIS-2302) for subcutaneous treatment of chronic active Crohn's disease (CACD): Lack of efficacy in a prospective, double-blind, multicenter randomized trial
112. Contrasting effects of anti-adhesion molecule therapy in experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis
113. P-selectin deficiency exacerbates experimental glomerulonephritis: A protective role for endothelial P-selectin in inflammation
114. Making the T cell receptor go the distance: A topological view of T cell activation
115. Adhesion molecule expression and regulation on cells of the central nervous system
116. The development of experimental autoimmune encephalomyelitis in the mouse requires α4-integrin but not α4β7-integrin
117. Anti-α 4 integrin antibody induces apoptosis in murine thymocytes and staphylococcal enterotoxin B-activated lymph node T cells
118. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin
119. Interaction of α4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro
120. Regulation of human T lymphocyte coactivation with an α4 integrin antagonist peptide
121. A predominant role of integrin α4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice
122. Role of α4-integrins in lymphocyte homing to mucosal tissues in vivo
123. Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM-1
124. The third function of the thymus
125. Regulatory T cells: Key controllers of immunologic self-tolerance
126. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression
127. The effect of graft-versus-host disease on T cell production and homeostasis
128. The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo
129. A homing selection hypothesis for T-cell trafficking
130. Initiation and perpetuation of rat adjuvant arthritis is inhibited by the anti-CD2 monoclonal antibody (mAb) OX34
131. Inflammatory bowel disease: Etiology and pathogenesis
132. Immunotherapy of Crohn's disease
133. How do lymphocytes know where to go: Current concepts and enigmas of lymphocyte homing
134. T-cell function and migration. Two sides of the same coin
135. + lymphocytes in three-dimensional collagen lattices
136. Antigen presentation in extracellular matrix: Interactions of T cells with dendritic cells are dynamic, short lived, and sequential
137. IFN-γ influences the migration of thoracic duct B and T lymphocyte subsets in vivo. Random increase in disappearance from the blood and differential decrease in reappearance in the lymph
138. +) continuously migrate through lymphoid organs: Within the tissue they alter surface molecule expression
139. T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells
140. Immunology: Improving on nature in the twenty-first century
141. Functional diversity of helper T lymphocytes
142. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
143. + immunoregulatory T cells is antigen nonspecific
144. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
145. Protection of trinitrobenzene sulfonic acid-induced colitis by an interleukin 2-IgG2b fusion protein in mice
146. + T cells
147. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease
148. Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice
149. The role of ICAM-1/LFA-1 and VCAM-1/VLA-4 interactions on T helper 2 cytokine production by lung T cells of Toxocara canis-infected mice
150. Clinical trials of antibody therapy
151. A targeted DNA vaccine encoding fas ligand defines its dual role in the regulation of experimental autoimmune encephalomyelitis
152. Targeting immunotherapy in multiple sclerosis: A near hit and a clear miss