Experimental models to study molecular mechanisms underlying intestinal inflammation

Annals of the New York Academy of Sciences

Volumn 859, Issue , 1998, Pages 85-95

  Elson, Charles O ^a   Cong, Y ^a   Brandwein, S ^a   Weaver, C T ^b   McCabe, R P ^a   Mahler M ^c   Sundberg, J P ^c   Leiter, E H ^c  

^a University of Alabama at Birmingham School of Medicine   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; BACTERIAL FLORA; COLITIS; CONFERENCE PAPER; EFFECTOR CELL; ENTERITIS; GENETIC SUSCEPTIBILITY; MOUSE; NONHUMAN; T LYMPHOCYTE;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0032435314     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb11113.x     Document Type: Conference Paper

References (46)

1. 1. DIELEMAN, L. A., C. O. ELSON, G. S. TENNYSON & K. W. BEAGLEY. 1996. Kinetics of cytokine expression during healing of acute colitis in mice. Am. J. Physiol. 34: G130-136.
2. 2. ABREU-MARTIN, M. T. & S. R. TARGAN. 1996. Regulation of immune responses of the intestinal mucosa. Crit. Rev. Immunol. 16: 277-309.
3. 3. ELSON, C. O. & R. P. J. McCABE. 1995. The immunology of inflammatory bowel disease. In Inflammatory Bowel Disease. J. B. Kirsner and R. G. Shorter, Ed: 203-251. Williams & Wilkins. Baltimore, MD.
4. + T cells are responsible for murine interleukin-2-deficient colitis. Eur. J. Immunol. 25: 2618-2625.
5. 5. MIZOGUCHI, A., E. MIZOGUCHI, C. CHIBA, G. M. SPIEKERMANN, S. TONEGAWA, C. NAGLER-ANDERSON & A. K. BHAN. 1996. Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease. J. Exp. Med. 183: 847-856.
6. + T-cell population mediates development of inflammatory bowel disease in T-cell receptor alpha-deficient mice. Gastroenterology 112: 1876-1882.
7. 7. NEURATH, M. F., I. FUSS, B. L. KELSALL, E. STUBER & W. STROBER. 1995. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182: 1281-1290.
8. 8. EHRHARDT, R. O., B. R. LUDVIKSSON, B. GRAY, M. NEURATH & W. STROBER. 1997. Induction and prevention of colonic inflammation in IL-2-deficient mice. J. Immunol. 158: 566-573.
9. 9. SUNDBERG, J. P., C. O. ELSON, H. BEDIGIAN & E. H. BIRKENMEIER. 1994. Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice. Gastroenterology 107: 1726-1735.
10. + T cell reactivity to enteric bacterial antigens in colitic C3H/HeJBir mice. Gastroenterology 110: A887.
11. + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 5: 1461-1471.
12. + T cells. J. Exp. Med. 183: 2669-2674.
13. 13. ELSON, C. O., K. W. BEAGLEY, A. T. SHARMANOV, K. FUJIHASHI, H. KIYONO, G. S. TENNYSON, Y. Z. CONG, C. A. BLACK, B. W. RIDWAN & J. R. MCGHEE. 1996. Hapten-induced model of murine inflammatory bowel disease-mucosal immune responses and protection by tolerance. J. Immunol. 157: 2174-2185.
14. 14. NEURATH, M. F., I. FUSS, B. L. KELSALL, D. H. PRESKY, W. WAEGELL & W. STROBER. 1996. Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance. J. Exp. Med. 183: 2605-2616.
15. +, CD45RBhigh T cells to SCID recipients. J Immunol. 158: 3464-3473.
16. +/CD45RBlo T cells. Res. Immunol. 145: 357-362.
17. 17. CRABBE, P. A., H. BAZIN, H. EYSSEN & J. F. HEREMANS. 1968. The normal microbial flora as a major stimulus for proliferation of plasma cells synthesizing IgA in the gut. The germ-free intestinal tract. Int. Arch. Allergy 34: 362-375.
18. 18. ABRAMS, G. D., H. BAUER & H. SPRINZ. 1963. Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. Lab. Invest. 12: 355-364.
19. 19. OKADA, Y., H. SETOYAMA, S. MATSUMOTO, A. IMAOKA, M. NANNO, M. KAWAGUCHI & Y. UMESAKI. 1994. Effects of fecal microorganisms and their chloroform-resistant variants derived from mice, rats, and humans on immunological and physiological characteristics of the intestines of ex-germfree mice. Infect. Immun. 62: 5442-5446.
20. 20. KLAASEN, H. L., J. P. KOOPMAN, M. E. VAN DEN BRINK, M. H. BAKKER, F. G. POELMA & A. C. BEYNEN. 1993. Intestinal, segmented, filamentous bacteria in a wide range of vertebrate species. Lab. Anim. 27: 141-150.
21. 21. JEPSON, M. A., M. A. CLARK, N. L. SIMMONS & B. H. HIRST. 1993. Actin accumulation at sites of attachment of indigenous apathogenic segmented filamentous bacteria to mouse ileal epithelial cells. Infect. Immun. 61: 4001-4004.
22. 22. KLAASEN, H. L., P. J. VAN DER HEIJDEN, W. STOK, F. G. POELMA, J. P. KOOPMAN, M. E. VAN DEN BRINK, M. H. BAKKER, W. M. ELING & A. C. BEYNEN. 1993. Apathogenic, intestinal, segmented, filamentous bacteria stimulate the mucosal immune system of mice. Infect. Immun. 61: 303-306.
23. 23. UMESAKI, Y., Y. OKADA, S. MATSUMOTO, A. IMAOKA & H. SETOYAMA. 1995. Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex-germ-free mouse. Microbiol. Immunol. 39: 555-562.
24. 24. RATH, H. C., H. H. HERFARTH, J. S. IKEDA, W. B. GRENTHER, T. E. HAMM, JR., E. BALISH, J. D. TAUROG, R. E. HAMMER, K. H. WILSON & R. B. SARTOR. 1996. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J. Clin. Invest. 98: 945-953.
25. 25. BRANDWEIN, S. L., R. P. MCCABE, Y. CONG, K. B. WAITES, B. U. RIDWAN, P. A. DEAN, T. OHKUSA, E. H. BIRKENMEIER, J. P. SUNDBERG & C. O. ELSON. 1997. Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J. Immunol. 159: 44-52.
26. 26. POLLARD, M. & N. SHARON. 1970. Responses of the Peyer's patches in germ-free mice to antigenic stimulation. Infect. Immun. 2: 96-100.
27. 27. SHROFF, K. E., K. MESLIN & J. J. CEBRA. 1995. Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut. Infect. Immun. 63: 3904-3913.
28. 28. BERG, R. D. & D. C. SAVAGE. 1975. Immune responses of specific pathogen-free and gnotobiotic mice to antigens of indigenous and nonindigenous microorganisms. Infect. Immun. 11: 320-329.
29. 29. DUCHMANN, R., E. SCHMITT, P. KNOLLE, K. H. MEYER ZUM BÜSCHENFELDE & M. NEURATH. 1996. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur. J. Immunol. 26: 934-938.
30. 30. DUCHMANN, R., I. KAISER, E. HERMANN, W. MAYET, K. EWE & K. H. MEYER ZUM BÜSCHENFELDE. 1995. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin. Exp. Immunol. 102: 448-455.
31. 31. ROTTER, J. & H. YANG. 1993. Resolving the genetics of IBD: The challenge for the 90's. Prog. Inflamm. Bowel Dis. 14: 1-7.
32. 32. HUGOT, J. P., P. LAURENT PUIG, C. GOWER ROUSSEAU, J. M. OLSON, J. C. LEE, L. BEAUGERIE, I. NAOM, J. L. DUPAS, A. VAN GOSSUM, M. ORHOLM, C. BONAITI PELLIE, J. WEISSENBACH, C. G. MATHEW, J. E. LENNARD JONES, A. CORTOT, J. F. COLOMBEL & G. THOMAS. 1996. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 379: 821-823.
33. 33. SATSANGI, J., M. PARKES, E. LOUIS, L. HASHIMOTO, N. KATA, K. WELSH, J. TERWILLIGER, G. LATHROP, J. BELL & D. JEWELL. 1996. Two stage genome-wide search in inflammatory bowel disease-evidence for susceptibility loci on chromosome 3, 7, and 12. Nat. Genet. 14: 199-202.
34. 34. SUNDBERG, J. P. 1991. Mouse mutations: Inherited disease models and biomedical tools. Lab. Anim. 20: 40-49.
35. 35. SUNDBERG, J. P. 1993. Conceptual evaluation of animal models as tools for the study of diseases in other species. Lab. Anim. 21: 48-51.
36. 36. MÄHLER, M., E. H. LEITER, E. H. BIRKENMEIER, I. J. BRISTOL, A. TORREY, C. O. ELSON & J. P. SUNDBERG. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am. J. Physiol. 274: G544-551.
37. 37. MÄHLER, M., J. SUNDBERG, E. H. BIRKENMEIER, I. J. BRISTOL, C. O. ELSON & E. H. LEITER. 1997. Chromosomal location of genes determining susceptibility of mice to dextran sulfate sodium (DSS)-induced colitis. Gastroenterology 112: A1031.
38. 38. SADLACK, B., H. MERZ, H. SCHORLE, A. SCHIMPL, A. C. FELLER & I. HORAK. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261.
39. 39. WILLERFORD, D. M., J. CHEN, J. A. FERRY, L. DAVIDSON, A. MA & F. W. ALT. 1995. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 3: 521-530.
40. 40. KUHN, R., J. LOHLER, D. RENNICK, K. RAJEWSKY & W. MULLER. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75: 263-274.
41. 41. MOMBAERTS, P., E. MIZOGUCHI, M. J. GRUSBY, L. H. GLIMCHER, A. K. BHAN & S. TONEGAWA. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75: 1-20.
42. + T cells. J. Exp. Med. 178: 237-244.
43. 43. HOLLANDER, G. A., S. J. SIMPSON, E. MIZOGUCHI, A. NICHOGIANNOPOULOU, J. SHE, J. C. GUTIERREZ-RAMOS, A. K. BHAN, S. J. BURAKOFF, B. WANG, & C. TERHORST. 1995. Severe colitis in mice with aberrant thymic selection. Immunity. 3: 27-38.
44. 44. RUDOLPH, U., M. J. FINEGOLD, S. S. RICH, G. R. HARRIMAN, Y. SRINIVASAN, P. BRABET, G. BOULAY, A. BRADLEY & L. BIRNBAUMER. 1995. Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat. Genet. 10: 143-150.
45. 45. HERMISTON, M. L. & J. I. GORDON. 1995. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 270: 1203-1207.
46. 46. OKAYASU, I., S. HATAKEYAMA, M. YAMADA, T. OHKUSA, Y. INAGAKI & R. NAKAYA. 1990. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98: 694-702.