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Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin
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VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site
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Elices MJ, Osborn L, Takada Y, Crouse C, Luhowskyj S, Hemler ME, Lobb RR: VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 1990, 60:577-584.
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4 integrin monoclonal antibody. J Clin Invest 1993, 92: 372-380.
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Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep
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Abraham WM, Sielczak MW, Ahmed A, Cortes A, Lauredo IT, Kim J, Pepinsky B, Benjamin CD, Leone DR, Lobb RR et al.: Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep. J Clin Invest 1994, 93:776-787.
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Lobb RR, Pepinsky B, Leone DR, Abraham WM: The role of alpha 4 integrins in lung pathophysiology. Eur Respir J 1996, 9(suppl):104-108.
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In situ expression of the cell adhesion molecules in inflammatory bowel disease. Evidence of immunologic activation of vascular endothelial cells
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Nakamura S, Ohtani H, Watanabe Y, Fukushima K, Matsumoto T, Kitano A, Kobayashi K, Nagura H: In situ expression of the cell adhesion molecules in inflammatory bowel disease. Evidence of immunologic activation of vascular endothelial cells. Lab Invest 1993, 69:77-85.
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Wayner EA, Kovach NL: Activation-dependent recognition by hematopoietic cells of the LDV sequence in the V region of fibronectin. J Cell Biol 1992, 16:489-497.
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Bochner BS, Luscinskas FW, Gimbrone MA Jr, Newman W, Sterbinsky SA, Derse-Anthony CP, Klunk D, Schleimer RP: Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J Exp Med 1991, 173:1553-1557
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A cyclic hexapeptide is a potent antagonist of alpha 4 integrins
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Vanderslice P, Ren K, Revelle JK, Kim DC, Scott D, Bjercke RJ, Yeh ET, Beck PJ, Kogan TP: A cyclic hexapeptide is a potent antagonist of alpha 4 integrins. J Immunol 1997, 158:1710. This describes the design and discovery of a potent cyclic peptide VLA4 antagonist.
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Vanderslice, P.1
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Tamraz S, Arrhenius T, Chiem A, Forrest MJ, Gaeta FC, He YB, Lei J, Maewal A, Phillips ML, Vollger LW et al.: Treatment of delayedtype hypersensitivity with inhibitors of the VLA-4 integrin. Springer Semin Immunopathol 1995, 16:437-441.
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Abraham WM, Ahmed A, Sielczak MW, Narita M, Arrhenius TS, Elices MJ: Blockade of late-phase airway responses and airway hyperresponsiveness in allergic sheep with a small-molecule peptide inhibitor of VLA-4. Am J Respir Crit Care Med 1997, 156:696-703. This paper describes the design of effective small-molecule VLA4 antagonists.
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1 peptide antagonists as potential anti-inflammatory agents. J Med Chem 1997, 40:3359-3368. This paper describes the discovery of a cyclic VLA4 antagonist peptides that function in the nanomolar range.
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Novel -ψ-S-CH2 peptide-bond replacement and its utilization in the synthesis of nonpeptidic surrogates of the Leu-Asp-Val sequence that exhibit specific inhibitory activities on CD4+ T cell binding to fibrinectin
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Greenspoon N, Hershkoviz R, Alon R, Gershonov E, Lavie B, Lider O: Novel -ψ-S-CH2 peptide-bond replacement and its utilization in the synthesis of nonpeptidic surrogates of the Leu-Asp-Val sequence that exhibit specific inhibitory activities on CD4+ T cell binding to fibrinectin. Int J Peptide Protein Res 1994, 43:417-434.
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