T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis

Investigative Ophthalmology and Visual Science

Volumn 39, Issue 5, 1998, Pages 754-762

  Prendergast, Robert A ^a,c   Iliff, Charles E ^a   Coskuncan, Nezih M ^a   Caspi, Rachel R ^b   Sartani, Gil ^b   Tarrant, Teresa K ^b   Lutty, Gerard A ^a   McLeod, D Scott ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; RETINA S ANTIGEN;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONTROLLED STUDY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA CELL; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; UVEORETINITIS;

ADOPTIVE TRANSFER; ANIMALS; ARRESTIN; AUTOIMMUNE DISEASES; CONCANAVALIN A; CYTOKINES; DISEASE MODELS, ANIMAL; FLUORESCENT DYES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; ORGANIC CHEMICALS; RATS; RATS, INBRED LEW; RETINA; RETINITIS; T-LYMPHOCYTES; UVEITIS, ANTERIOR; UVEITIS, POSTERIOR;

EID: 0031965903     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Wacker WB. Experimental allergic uveitis. Investigations of retinal autoimmunity and the immunopathogenic responses evoked. Invest Ophthalmol Vis Sci. 1991;32:3119-3128.
2. Caspi RR. Basic mechanisms in immune-mediated uveitic disease. In: Lightman SL, ed. Immunology of Eye Diseases. Lancaster, UK: Kluwer; 1989:61-86.
3. Gery I, Streilein JW. Autoimmunity in the eye and its regulation. Curr Opin Immunol. 1994;6:938-945.
4. Caspi RR, Roberge FG, McAllister CG, et al. T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat. J Immunol. 1986;136:928-933.
5. Gregerson DS, Obritsch WF, Fling SP, Cameron JD. S-antigen-specific rat T cell lines recognize peptide fragments of S-antigen and mediate experimental autoimmune uveoretinitis and pinealitis. J Immunol. 1986;136:2875-2882.
6. Savion S, Oddo S, Grover S, Caspi RR. Uveitogenic T lymphocytes in the rat. Pathogenicity vs lymphokine production, adhesion molecules and surface antigen expression. J Neuroimmunol. 1994;55: 35-44.
7. Greenwood J, Howes R, Lightman S. The blood-retinal barrier in experimental autoimmune uveoretinitis: Leukocyte interactions and functional damage. Lab Invest. 1994;70:39-52.
8. Wang YF, Calder VL, Greenwood J, Lightman SL. Lymphocyte adhesion to cultured endothelial cells of the blood retinal barrier. J Neuroimmunol. 1993;48:161-168.
9. McCluskey RT, Benacerraf B, McCluskey JW. Studies on the specificity of the cellular infiltrate in delayed hypersensitivity reactions. J Immunol. 1963;90:466-477.
10. Prendergast RA. Cellular specificity in the homograft reaction. J Exp Med. 1964;119:377-388.
11. Werdelin O, McCluskey RT. The nature and the specificity of mononuclear cells in experimental autoimmune inflammations and the mechanisms leading to their accumulation. J Exp Med. 1971;133:1242-1263.
12. Lightman SL, Caspi RR, Nussenblatt RB, Palestine AG. Antigen-directed retention of an autoimmune T cell line. Cell Immunol. 1987;110:28-34.
13. Horan PK, Slezak SE. Stable cell membrane labelling. Nature. 1989;340:167-168.
14. Slezak SE, Horan PK. Fluorescent in vivo tracking of hematopoietic cells. Blood. 1990;74:2171.
15. Laver NM, Robison WG, Pfeffer BA. Novel methods for isolating intact retinal vascular beds from diabetic humans and animal models. Invest Ophthalmol Vis Sci. 1993;34:2097-2104.
16. James SP. Measurement of proliferative responses in cultured lymphocytes. In: Coligan JE, Kruisbeck AM, Margulies DH, Shevach EM, Strober W, eds. Current Protocols in Immunology. New York: Wiley; 1994;7.10.1-7.10.10.
17. Whitcup SM, DeBorge LR, Caspi RR, Harning R, Nussenblatt RB, Chan CC. Monoclonal antibodies against ICAM-1 and LFA-1 (CD11a/CD18) inhibit experimental autoimmune uveitis. Clin Immunol Immunopathol. 1993;67:143-150.
18. Picker LJ, Kishimoto TK, Smith CW, Warnock RA, Butcher EC. ELAM-1 is an adhesion molecule for skin-homing T cells. Nature. 1991;349:796-798.
19. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301-314.
20. Prendergast, RA, Coskuncan NM, McLeod DS, Lutty GA, Caspi RR. T cell traffic and the pathogenesis of experimental autoimmune uveoretinitis. In: Nussenblatt RB, Whitcup SM, Caspi, RR, Gery I, eds. Advances in Ocular Immunology. New York: Elsevier; 1994: 59-62.
21. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science. 1995;270:1189-1192.
22. Stuart PM, Griffith TS, Usui N, Pepose JS, Yu X, Ferguson TA. CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival. J Clin Invest. 1997;99:396-402.
23. Griffith TS, Ferguson TA. The role of FasL-induced apoptosis in immune privilege. Immunol Today. 1997;18:240-244.
24. Hickey WF, Kimura H. Perivascular microglia are bone marrow derived and present antigen in vivo. Science. 1988;239:290-292.
25. Zhang X, Brunner T, Carter L, et al. Unequal death in T helper cell (Th) 1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J Exp Med. 1997;185:1837-1849.
26. McMenamin PG, Crewe J, Morrison S, Holt PG. Immunomorphological studies of macrophages and MHC class II-positive dendritic cells in the iris and ciliary body of the rat, mouse and human eye. Invest Ophthalmol Vis Sci. 1994;35:3234-3250.
27. Steptoe RJ, Holt PG, McMenamin PG. Demonstration of the immunostimulatory capacity of dendritic cells isolated from the rat iris. Immunology. 1995;85:630-637.
28. Butler TL, McMenamin PG. Resident and infiltrating immune cells in the uveal tract in early and late stages of experimental autoimmuune uveoretinitis. Invest Ophthalmol Vis Sci. 1996;37:2195-2210.
29. Singh AK, Kumar G, Shinohara T, Shichi H. Porcine S-antigen. cDNA sequence and expression in retina, ciliary 1 epithelium and iris. Exp Eye Res. 1996;62:299-308.
30. Nicolas C, Ghedira I, Faure JP, Mirshahi M. β-arrestin related proteins in ocular tissues [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1997;38:S320. Abstract nr 1494.
31. Prendergast RA, Caspi RR, Tarrant TK, Iliff CE. Class II positive antigen-presenting cells in retina and iris in T cell-induced EAU [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1997;38: S1159. Abstract nr 5407
32. Forrester JV, McMenamin PG, Holthouse I, Lumsden L, Liversidge J. Localization and characterization of major histocompatibility complex class II-positive cells in the posterior segment of the eye: Implications for induction of autoimmune uveoretinitis. Invest Ophthalmol Vis Sci. 1994;35:64-77.
33. Yang P, de Vos AF, Kijlstra A. Macrophages in the retina of normal Lewis rats and their dynamics after injection of lipopolysaccharide. Invest Ophthalmol Vis Sci. 1996;37:77-85.
34. Hickey WF, Hsu BL, Kimura H. T-lymphocyte entry into the central nervous system. J Neurosci Res. 1991;28:254-260.
35. Bauer J, Huitinga I, Zhao W, Lassmann H, Hickey WF, Dijkstra CD. The role of macrophages, perivascular cells, and microglia in the pathogenesis of experimental autoimmune encephalomyelitis. Glia. 1995;15:437-446.